| Drug General Information |
| Drug ID |
D0Y8NO
|
| Former ID |
DNC007551
|
| Drug Name |
RTI-5989-31
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H29NO
|
| Canonical SMILES |
CC1C2CCCC1(CCN2CCC3=CC=CC=C3)C4=CC(=CC=C4)O
|
| InChI |
1S/C23H29NO/c1-18-22-11-6-13-23(18,20-9-5-10-21(25)17-20)14-16-24(22)15-12-19-7-3-2-4-8-19/h2-5,7-10,17-18,22,25H,6,11-16H2,1H3
|
| InChIKey |
FJRARMQVERMSNJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Mu-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
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Morphine addiction
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signalingWP69:TCR Signaling Pathway
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Opioid Signalling
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GPCR downstream signaling
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| References |
| REF 1 | J Med Chem. 2007 Aug 9;50(16):3765-76. Epub 2007 Jul 11.Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. |
|---|
