Drug Information
Drug General Information | |||||
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Drug ID |
D00TNR
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Former ID |
DNC006750
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Drug Name |
ENDOMORPHIN 2
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [540499] | ||
Structure |
Download2D MOL |
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Formula |
C32H37N5O5
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InChI |
InChI=1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1
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InChIKey |
XIJHWXXXIMEHKW-LJWNLINESA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Mu-type opioid receptor | Target Info | Inhibitor | [531092] | |
Delta-type opioid receptor | Target Info | Inhibitor | [531092] | ||
Substance-P receptor | Target Info | Inhibitor | [530745] | ||
Kappa-type opioid receptor | Target Info | Inhibitor | [526937] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Enkephalin release | |||||
Opioid proenkephalin pathway | |||||
Opioid proopiomelanocortin pathwayP06959:CCKR signaling map STP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Opioid prodynorphin pathway | |||||
Pathway Interaction Database | IL4-mediated signaling events | ||||
WikiPathways | TCR Signaling Pathway | ||||
GPCRs, Class A Rhodopsin-like | |||||
Peptide GPCRs | |||||
Opioid Signalling | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
GPCR downstream signalingWP706:SIDS Susceptibility Pathways | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Spinal Cord Injury | |||||
GPCR downstream signaling | |||||
References | |||||
Ref 526937 | J Med Chem. 2004 Jan 29;47(3):735-43.Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. | ||||
Ref 530745 | J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. | ||||
Ref 531092 | Eur J Med Chem. 2010 Oct;45(10):4594-600. Epub 2010 Jul 21.Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. |
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