Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T13260
|
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Former ID |
TTDS00252
|
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Target Name |
Cytochrome P450 19
|
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Gene Name |
CYP19A1
|
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Synonyms |
Aromatase; CYPXIX; Estrogen synthetase; P-450AROM; CYP19A1
|
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Target Type |
Successful
|
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Disease | Advanced breast cancer [ICD9: 174, 175; ICD10: C50] | ||||
Bladder cancer [ICD9: 188; ICD10: C67] | |||||
Breast cancer [ICD9: 174, 175; ICD10: C50] | |||||
Cushing's disease; Metastatic breast cancer [ICD9: 174, 175, 255.0; ICD10: C50, E24] | |||||
Dermatological disease [ICD10: L00-L99] | |||||
Endometriosis [ICD9: 617; ICD10: N80] | |||||
Hormonally-responsive breast cancer [ICD9: 174, 175; ICD10: C50] | |||||
Painful diabetic neuropathy [ICD9: 250.6,338,780; ICD10: E10.4, E11.4, E13.4, G89, R52] | |||||
Prostate disease [ICD10: N42.9] | |||||
Unspecified [ICD code not available] | |||||
Function |
Catalyzesthe formation of aromatic C18 estrogens from C19 androgens.
|
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BioChemical Class |
Oxidoreductases acting on paired donors
|
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Target Validation |
T13260
|
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UniProt ID | |||||
EC Number |
EC 1.14.14.1
|
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Sequence |
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH PDETKNMLEMIFTPRNSDRCLEH |
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Drugs and Mode of Action | |||||
Drug(s) | Aminoglutethimide | Drug Info | Approved | Cushing's disease; Metastatic breast cancer | [535103], [542065] |
Anastrozole | Drug Info | Approved | Breast cancer | [468200], [536772] | |
Exemestane | Drug Info | Approved | Hormonally-responsive breast cancer | [536361], [542079] | |
FADROZOLE | Drug Info | Approved | Breast cancer | [543063], [544743], [551871] | |
Letrozole | Drug Info | Approved | Hormonally-responsive breast cancer | [468263], [536772] | |
Testolactone | Drug Info | Approved | Advanced breast cancer | [536361], [542325] | |
Atamestane-plus- Toremifene | Drug Info | Phase 3 | Breast cancer | [521531] | |
LIAROZOLE | Drug Info | Phase 2/3 | Dermatological disease | [468265], [521791] | |
BGS-649 | Drug Info | Phase 2 | Endometriosis | [523148] | |
COUMATE | Drug Info | Phase 2 | Breast cancer | [531371] | |
Dextromethorphan+quinidine | Drug Info | Phase 2 | Painful diabetic neuropathy | [536078] | |
NARINGENIN | Drug Info | Phase 1 | Discovery agent | [522980] | |
FORMESTANE | Drug Info | Withdrawn from market | Breast cancer | [544725], [551871] | |
FINROZOLE | Drug Info | Discontinued in Phase 2 | Prostate disease | [546744] | |
NKS-01 | Drug Info | Discontinued in Phase 2 | Bladder cancer | [545382] | |
VOROZOLE | Drug Info | Discontinued in Phase 2 | Discovery agent | [545194] | |
YM-511 | Drug Info | Discontinued in Phase 2 | Breast cancer | [545290] | |
MINAMESTANE | Drug Info | Terminated | Bladder cancer | [545235] | |
Rogletimide | Drug Info | Terminated | Breast cancer | [544813] | |
Inhibitor | (+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one | Drug Info | [528848] | ||
(+/-)-7-methoxy-2-phenylchroman-4-one | Drug Info | [529180] | |||
(2S)-5,7,2',4'-tetrahydroxyflavanone | Drug Info | [526180] | |||
(2S)-abyssinone II | Drug Info | [526180] | |||
(2S)-euchrenone a7 | Drug Info | [526180] | |||
1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole | Drug Info | [529684] | |||
1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole | Drug Info | [529860] | |||
1-(2-phenoxybenzyl)-1H-imidazole | Drug Info | [551345] | |||
1-(3-(4-fluorophenyl)propyl)-1H-imidazole | Drug Info | [530867] | |||
1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole | Drug Info | [527801] | |||
1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone | Drug Info | [551225] | |||
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole | Drug Info | [529291] | |||
1-(4-nitro-2-phenoxybenzyl)-1H-imidazole | Drug Info | [551345] | |||
1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole | Drug Info | [551345] | |||
1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole | Drug Info | [527222] | |||
1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole | Drug Info | [529860] | |||
1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole | Drug Info | [530867] | |||
1-(9H-fluoren-9-yl)-1H-imidazole | Drug Info | [529860] | |||
1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole | Drug Info | [530712] | |||
1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one | Drug Info | [535139] | |||
1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole | Drug Info | [525448] | |||
1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | Drug Info | [535139] | |||
1-Imidazol-1-ylmethylxanthen-9-one | Drug Info | [551345] | |||
1-Naphthalen-2-yl-1H-imidazole | Drug Info | [527801] | |||
1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole | Drug Info | [530867] | |||
10-EPI-8-DEOXY-CUMAMBRIN B | Drug Info | [530867] | |||
11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B | Drug Info | [530867] | |||
2,3,4-Trimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
2,3,5-Trimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
2,3-Dimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
2,4-Dimethoxy-3'-amino-trans-stilbene | Drug Info | [551225] | |||
2,4-Dimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
2,5-Dimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | Drug Info | [551225] | |||
2-(3-hydroxyphenyl)-7-methoxychroman-4-one | Drug Info | [529180] | |||
2-(4-hydroxyphenyl)-7-methoxychroman-4-one | Drug Info | [529180] | |||
2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one | Drug Info | [527565] | |||
2-Imidazol-1-ylmethylxanthen-9-one | Drug Info | [551345] | |||
2-phenyl-2,3-dihydrobenzo[h]chromen-4-one | Drug Info | [529180] | |||
2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one | Drug Info | [526300] | |||
2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol | Drug Info | [527222] | |||
3,4'-(Ethane-1,2-diyl)dibenzenamine | Drug Info | [551225] | |||
3,4,5-Trimethoxy-3'-amino-trans-stilbene | Drug Info | [551225] | |||
3,4,5-Trimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one | Drug Info | [530867] | |||
3,4-Dimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3,5-Diacetoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3,5-Diamino-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3,5-Dihydroxyl-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3,5-Dimethoxy-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | Drug Info | [551345] | |||
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine | Drug Info | [528109] | |||
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine | Drug Info | [528109] | |||
3-(2,2-Diphenyl-vinyl)-pyridine | Drug Info | [527456] | |||
3-(3,4-dihydronaphthalen-2-yl)pyridine | Drug Info | [528109] | |||
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine | Drug Info | [528109] | |||
3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione | Drug Info | [533480] | |||
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione | Drug Info | [533478] | |||
3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione | Drug Info | [533480] | |||
3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione | Drug Info | [533478] | |||
3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione | Drug Info | [533478] | |||
3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione | Drug Info | [533480] | |||
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione | Drug Info | [533478] | |||
3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione | Drug Info | [533478] | |||
3-(4-Amino-phenyl)-pyrrolidine-2,5-dione | Drug Info | [533480] | |||
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine | Drug Info | [528109] | |||
3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine | Drug Info | [527801] | |||
3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine | Drug Info | [527801] | |||
3-(6-Ethoxy-naphthalen-2-yl)-pyridine | Drug Info | [527801] | |||
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | Drug Info | [528109] | |||
3-(6-methoxynaphthalen-2-yl)pyridine | Drug Info | [529834] | |||
3-(imidazolylmethyl)-4'-methoxyflavone | Drug Info | [528327] | |||
3-(imidazolylmethyl)-4'-nitroflavone | Drug Info | [528327] | |||
3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone | Drug Info | [528327] | |||
3-(imidazolylmethyl)flavone | Drug Info | [528327] | |||
3-(naphthalen-2-yl)pyridine | Drug Info | [529834] | |||
3-Amino-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3-Fluoren-9-ylidenemethyl-pyridine | Drug Info | [527456] | |||
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol | Drug Info | [531085] | |||
3-Indan-(1E)-ylidenemethyl-pyridine | Drug Info | [527456] | |||
3-Indan-(1Z)-ylidenemethyl-pyridine | Drug Info | [527456] | |||
3-Methoxyl-4'-amino-trans-stilbene | Drug Info | [551225] | |||
3-Nitro-4'-nitro-trans-stilbene | Drug Info | [551225] | |||
3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol | Drug Info | [531085] | |||
4'-(Pyridin-4-ylmethyl)biphenyl-3-amine | Drug Info | [531085] | |||
4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone | Drug Info | [528327] | |||
4'-bromo-3-(imidazolylmethyl)flavone | Drug Info | [528327] | |||
4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone | Drug Info | [528327] | |||
4'-cyano-3-(imidazolylmethyl)flavone | Drug Info | [528327] | |||
4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one | Drug Info | [529860] | |||
4-((1H-imidazol-1-yl)methyl)benzonitrile | Drug Info | [529291] | |||
4-(1-Imidazol-1-yl-vinyl)-benzonitrile | Drug Info | [534057] | |||
4-(2,2-Diphenyl-vinyl)-pyridine | Drug Info | [527456] | |||
4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one | Drug Info | [529860] | |||
4-(3,4,5-Trimethoxyphenethyl)aniline | Drug Info | [551225] | |||
4-(3,4-Dimethoxyphenethyl)aniline | Drug Info | [551225] | |||
4-(3,5-Dimethoxyphenethyl)benzenamine | Drug Info | [551225] | |||
4-ANDROSTENE-3-17-DIONE | Drug Info | [551374] | |||
4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one | Drug Info | [535139] | |||
4-Fluoren-9-ylidenemethyl-pyridine | Drug Info | [527456] | |||
4-Imidazol-1-yl-2-phenyl-chroman-7-ol | Drug Info | [527222] | |||
4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one | Drug Info | [535139] | |||
4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one | Drug Info | [551345] | |||
4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one | Drug Info | [551345] | |||
4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one | Drug Info | [551345] | |||
4-Imidazol-1-ylmethylthioxanthen-9-one | Drug Info | [551345] | |||
4-Imidazol-1-ylmethylxanthen-9-one | Drug Info | [551345] | |||
4-Indan-(1E)-ylidenemethyl-pyridine | Drug Info | [527456] | |||
4-Indan-(1Z)-ylidenemethyl-pyridine | Drug Info | [527456] | |||
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine | Drug Info | [531085] | |||
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine | Drug Info | [531085] | |||
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine | Drug Info | [527456] | |||
5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline | Drug Info | [529860] | |||
5-(2-(1H-imidazol-1-yl)ethyl)quinoline | Drug Info | [529860] | |||
5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one | Drug Info | [535139] | |||
5-Indan-(1E)-ylidenemethyl-1H-imidazole | Drug Info | [527475] | |||
5-Indan-(1Z)-ylidenemethyl-1H-imidazole | Drug Info | [527475] | |||
5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one | Drug Info | [529834] | |||
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one | Drug Info | [529834] | |||
5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole | Drug Info | [527475] | |||
5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole | Drug Info | [527475] | |||
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine | Drug Info | [527456] | |||
5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine | Drug Info | [527456] | |||
5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole | Drug Info | [527456] | |||
5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole | Drug Info | [527456] | |||
6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione | Drug Info | [529860] | |||
6-Imidazol-1-yl-isoquinoline | Drug Info | [529860] | |||
7,4'-Dihydroxyflavone | Drug Info | [530867] | |||
7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one | Drug Info | [529860] | |||
7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one | Drug Info | [529860] | |||
7-((1H-imidazol-1-yl)methyl)isoquinoline | Drug Info | [529860] | |||
7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one | Drug Info | [527353] | |||
7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one | Drug Info | [529180] | |||
7-hydroxy-2-phenylchroman-4-one | Drug Info | [529180] | |||
7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one | Drug Info | [535139] | |||
8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one | Drug Info | [535139] | |||
9-Hydroxy-7,8-benzoflavone | Drug Info | [530867] | |||
ALBANOL A | Drug Info | [526180] | |||
ALPHA-NAPHTHOFLAVONE | Drug Info | [530867] | |||
Aminoglutethemide | Drug Info | [538153] | |||
Aminoglutethimide | Drug Info | [536445] | |||
Anastrozole | Drug Info | [535343], [535547] | |||
ANDROSTENEDIONE | Drug Info | [533863] | |||
ANDROSTENEDONE | Drug Info | [533387] | |||
APIGENIN | Drug Info | [530867] | |||
Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine | Drug Info | [529684] | |||
BGS-649 | Drug Info | [549087] | |||
BIOCHANIN | Drug Info | [530867] | |||
Broussoflavonol F | Drug Info | [526180] | |||
CGS-18320B | Drug Info | [530867] | |||
CHRYSIN | Drug Info | [530867] | |||
COUMATE | Drug Info | [530712] | |||
DEHYDROLEUCODIN | Drug Info | [530867] | |||
Dextromethorphan+quinidine | Drug Info | [536374] | |||
Docosapentaenoic acid | Drug Info | [528166] | |||
Exemestane | Drug Info | [535836] | |||
FADROZOLE | Drug Info | [527856] | |||
FINROZOLE | Drug Info | [526217], [551871] | |||
FORMESTANE | Drug Info | [530661] | |||
Gamma-mangostin | Drug Info | [529538] | |||
GARCINONE D | Drug Info | [529538] | |||
GOSSYPETIN | Drug Info | [529679] | |||
Isogemichalcone C | Drug Info | [526180] | |||
ISOLICOFLAVONOL | Drug Info | [526180] | |||
Letrozole | Drug Info | [535836] | |||
LIAROZOLE | Drug Info | [530867] | |||
LIQUIRTIGENIN | Drug Info | [529679] | |||
LUDARTIN | Drug Info | [530867] | |||
MDL-18962 | Drug Info | [534514] | |||
MINAMESTANE | Drug Info | [533913], [551871] | |||
MONODICTYOCHROMONE B | Drug Info | [529759] | |||
MORACHALCONE A | Drug Info | [526180] | |||
MR-16089 | Drug Info | [530867] | |||
MR-20492 | Drug Info | [530867] | |||
MR-20494 | Drug Info | [530867] | |||
MR-20496 | Drug Info | [534789] | |||
MR-20814 | Drug Info | [534789] | |||
N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide | Drug Info | [528691] | |||
N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide | Drug Info | [528035] | |||
N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide | Drug Info | [528035] | |||
N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide | Drug Info | [528035] | |||
N-[2-(4'-Nitrophenyl)ethyl]-imidazole | Drug Info | [530867] | |||
NARINGENIN | Drug Info | [530867] | |||
NKS-01 | Drug Info | [525727], [551871] | |||
NSC-122427 | Drug Info | [530190] | |||
NSC-12999 | Drug Info | [529860] | |||
NSC-131736 | Drug Info | [529860] | |||
NSC-19028 | Drug Info | [530867] | |||
NSC-289311 | Drug Info | [529860] | |||
NSC-356483 | Drug Info | [529860] | |||
NSC-356781 | Drug Info | [529860] | |||
NSC-368272 | Drug Info | [529860] | |||
NSC-368280 | Drug Info | [529860] | |||
NSC-369087 | Drug Info | [529860] | |||
NSC-613604 | Drug Info | [530190] | |||
NSC-625409 | Drug Info | [529860] | |||
NSC-666292 | Drug Info | [529860] | |||
NSC-683634 | Drug Info | [529860] | |||
NSC-75308 | Drug Info | [529860] | |||
NSC-93358 | Drug Info | [530190] | |||
NSC-94258 | Drug Info | [530867] | |||
NSC-94891 | Drug Info | [530190] | |||
Rogletimide | Drug Info | [533470] | |||
Testolactone | Drug Info | [535343], [538089] | |||
VOROZOLE | Drug Info | [529570] | |||
YM-511 | Drug Info | [526667] | |||
Modulator | Atamestane-plus- Toremifene | Drug Info | [529105] | ||
Org-33201 | Drug Info | ||||
Pathways | |||||
BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
Estradiol biosynthesis II | |||||
Estradiol biosynthesis I | |||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Metabolic pathways | |||||
Ovarian steroidogenesis | |||||
NetPath Pathway | FSH Signaling Pathway | ||||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
Reactome | Endogenous sterols | ||||
WikiPathways | Metapathway biotransformation | ||||
Tryptophan metabolism | |||||
Oxidation by Cytochrome P450 | |||||
Ovarian Infertility Genes | |||||
Metabolism of steroid hormones and vitamin D | |||||
FSH signaling pathway | |||||
Integrated Breast Cancer Pathway | |||||
Phase 1 - Functionalization of compounds | |||||
References | |||||
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Ref 468263 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5209). | ||||
Ref 468265 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5210). | ||||
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Ref 542065 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7054). | ||||
Ref 542079 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7073). | ||||
Ref 542325 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7303). | ||||
Ref 543063 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8311). | ||||
Ref 544725 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000733) | ||||
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Ref 533480 | J Med Chem. 1986 Apr;29(4):520-3.Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. | ||||
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Ref 538153 | Aromatase inhibitors and their use in the adjuvant setting. Recent Results Cancer Res. 1998;152:277-84. | ||||
Ref 549087 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032111) | ||||
Ref 551225 | Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. doi: 10.1016/j.bmc.2010.05.042. Epub 2010 May 24. |
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