| Drug General Information |
| Drug ID |
D0A2GB
|
| Former ID |
DNC004617
|
| Drug Name |
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H22N2O2
|
| Canonical SMILES |
CCCCCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)N
|
| InChI |
1S/C16H22N2O2/c1-2-3-4-10-16(11-9-14(19)18-15(16)20)12-5-7-13(17)8-6-12/h5-8H,2-4,9-11,17H2,1H3,(H,18,19,20)
|
| InChIKey |
VFLOMQQDKBQIOE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 11A1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
|
Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
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Pregnenolone biosynthesis
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathways
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Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
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Ovarian steroidogenesis
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NetPath Pathway
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FSH Signaling PathwayNetPath_25:FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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Androgen and Estrogen MetabolismPW000141:Steroidogenesis
|
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Reactome
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Endogenous sterolsR-HSA-211976:Endogenous sterols
|
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WikiPathways
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Metapathway biotransformation
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Tryptophan metabolism
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Oxidation by Cytochrome P450
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Ovarian Infertility Genes
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Metabolism of steroid hormones and vitamin D
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compoundsWP98:Prostaglandin Synthesis and Regulation
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Glucocorticoid & Mineralcorticoid Metabolism
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Corticotropin-releasing hormone
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Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | J Med Chem. 1986 Aug;29(8):1362-9.Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. |
|---|
