Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T23145
|
||||
| Former ID |
TTDS00419
|
||||
| Target Name |
Cytochrome P450 11A1, mitochondrial
|
||||
| Gene Name |
CYP11A1
|
||||
| Synonyms |
CYP11A; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; P450(scc); CYP11A1
|
||||
| Target Type |
Successful
|
||||
| Disease | Cushing's disease; Metastatic breast cancer [ICD9: 174, 175, 255.0; ICD10: C50, E24] | ||||
| Function |
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
|
||||
| BioChemical Class |
Oxidoreductases acting on paired donors
|
||||
| UniProt ID | |||||
| EC Number |
EC 1.14.15.6
|
||||
| Sequence |
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ |
||||
| Drugs and Mode of Action | |||||
| Drug(s) | Aminoglutethimide | Drug Info | Approved | Cushing's disease; Metastatic breast cancer | [1], [2] |
| Inhibitor | 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione | Drug Info | [3] | ||
| 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione | Drug Info | [3] | |||
| Aminoglutethimide | Drug Info | [1] | |||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Pregnenolone biosynthesis | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| Ovarian steroidogenesis | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PathWhiz Pathway | Steroidogenesis | ||||
| Reactome | Endogenous sterols | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Metapathway biotransformation | |||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & | |||||
| Mineralcorticoid Metabolism | |||||
| Corticotropin-releasing hormone | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| REF 1 | Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7054). | ||||
| REF 3 | J Med Chem. 1986 Aug;29(8):1362-9.Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.