Drug General Information
Drug ID	D0J8RR
Former ID	DCL000773
Drug Name	Dextromethorphan+quinidine
Drug Type	Small molecular drug
Indication	Painful diabetic neuropathy [ICD9: 250.6,338,780; ICD10:E10.4, E11.4, E13.4, G89, R52]		Phase 2	[536078]
Company	Avanir
Structure		Download 2D MOL 3D MOL
Formula	C18H28BrNO2
PubChem Compound ID	5462351
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[536374]
	NMDA receptor	Target Info	Antagonist	[536374]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 536078	Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
Ref 536374	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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