| Drug General Information |
| Drug ID |
D09HOE
|
| Former ID |
DNC004708
|
| Drug Name |
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H12FN
|
| Canonical SMILES |
C1CC(=CC2=CC=NC=C2)C3=C1C=C(C=C3)F
|
| InChI |
1S/C15H12FN/c16-14-3-4-15-12(1-2-13(15)10-14)9-11-5-7-17-8-6-11/h3-10H,1-2H2/b12-9-
|
| InChIKey |
KVRYTKBSTLSXKC-XFXZXTDPSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
| 17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
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Superpathway of steroid hormone biosynthesis
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Estradiol biosynthesis II
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Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
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Glucocorticoid biosynthesis
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Mineralocorticoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Androgen biosynthesis
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathways
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Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
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Ovarian steroidogenesis
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Prolactin signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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Androgen and Estrogen MetabolismPW000141:SteroidogenesisPW000045:Androgen and Estrogen Metabolism
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Steroidogenesis
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Reactome
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Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
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Endogenous sterolsR-HSA-193048:Androgen biosynthesis
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Glucocorticoid biosynthesis
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Endogenous sterols
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WikiPathways
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Metapathway biotransformation
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Tryptophan metabolism
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Oxidation by Cytochrome P450
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Ovarian Infertility Genes
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Metabolism of steroid hormones and vitamin D
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
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Corticotropin-releasing hormoneWP702:Metapathway biotransformation
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Steroid Biosynthesis
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Glucocorticoid & Mineralcorticoid Metabolism
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Prostate Cancer
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Phase 1 - Functionalization of compounds
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| References |
| REF 1 | J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. |
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