| Drug General Information |
| Drug ID |
D03EXD
|
| Former ID |
DNC011103
|
| Drug Name |
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H15NO2
|
| Canonical SMILES |
C1=CC(=CC=C1C2=CC=C(C=C2)O)C(C3=CC=NC=C3)O
|
| InChI |
1S/C18H15NO2/c20-17-7-5-14(6-8-17)13-1-3-15(4-2-13)18(21)16-9-11-19-12-10-16/h1-12,18,20-21H
|
| InChIKey |
ABUNZHUAYBOXCN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
| Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
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|
Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Mineralocorticoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Estradiol biosynthesis II
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Estradiol biosynthesis I
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathways
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Ovarian steroidogenesis
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Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
|
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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Androgen and Estrogen Metabolism
|
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SteroidogenesisPW000141:SteroidogenesisPW000045:Androgen and Estrogen Metabolism
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Reactome
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Androgen biosynthesis
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Glucocorticoid biosynthesis
|
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Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
|
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Endogenous sterolsR-HSA-211976:Endogenous sterols
|
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WikiPathways
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Metapathway biotransformation
|
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Steroid Biosynthesis
|
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Oxidation by Cytochrome P450
|
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Metabolism of steroid hormones and vitamin D
|
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Glucocorticoid & Mineralcorticoid Metabolism
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Prostate Cancer
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
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Corticotropin-releasing hormoneWP702:Metapathway biotransformation
|
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Tryptophan metabolism
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Ovarian Infertility Genes
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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|
Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | J Med Chem. 2010 Aug 12;53(15):5749-58.Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
|---|
