| Drug General Information |
| Drug ID |
D08RVN
|
| Former ID |
DNC004399
|
| Drug Name |
NSC-19028
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C15H10O2
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
|
| InChI |
1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
|
| InChIKey |
VHBFFQKBGNRLFZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Gamma-aminobutyric acid receptor |
Target Info |
Inhibitor |
[1]
|
| Cytochrome P450 19 |
Target Info |
Inhibitor |
[3]
|
| Gamma-aminobutyric acid receptor subunit alpha-1 |
Target Info |
Inhibitor |
[4]
|
| mRNA of androgen receptor |
Target Info |
Inhibitor |
[5]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
|
Estradiol biosynthesis I
|
|
KEGG Pathway
|
Steroid hormone biosynthesis
|
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Metabolic pathways
|
|
Ovarian steroidogenesishsa04080:Neuroactive ligand-receptor interaction
|
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Retrograde endocannabinoid signaling
|
|
GABAergic synapse
|
|
Morphine addiction
|
|
Nicotine addictionhsa04114:Oocyte meiosis
|
|
Pathways in cancer
|
|
Prostate cancer
|
|
NetPath Pathway
|
FSH Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
|
|
AndrogenReceptor Signaling Pathway
|
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FSH Signaling Pathway
|
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PANTHER Pathway
|
Androgen/estrogene/progesterone biosynthesis
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Coregulation of Androgen receptor activity
|
|
Regulation of Androgen receptor activity
|
|
Nongenotropic Androgen signaling
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
|
FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY network
|
|
PathWhiz Pathway
|
Androgen and Estrogen Metabolism
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (i) signalling eventsR-HSA-211976:Endogenous sterolsR-HSA-975298:Ligand-gated ion channel transport
|
|
GABA A receptor activationR-HSA-383280:Nuclear Receptor transcription pathway
|
|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
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GPCRs, OtherWP702:Metapathway biotransformation
|
|
Tryptophan metabolism
|
|
Oxidation by Cytochrome P450
|
|
Ovarian Infertility Genes
|
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Metabolism of steroid hormones and vitamin D
|
|
FSH signaling pathway
|
|
Integrated Breast Cancer Pathway
|
|
Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Iron uptake and transportWP706:SIDS Susceptibility Pathways
|
|
Integrated Pancreatic Cancer Pathway
|
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Prostate Cancer
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | J Med Chem. 2002 Sep 12;45(19):4188-201.Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. |
|---|
| REF 2 | J Med Chem. 1996 Feb 2;39(3):781-8.Interactions of flavonoids and other phytochemicals with adenosine receptors. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. Epub 2010 Apr 8.Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). |
|---|
| REF 4 | Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). |
|---|
| REF 5 | Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. Epub 2009 Jun 23.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. |
|---|
