Drug Information
Drug General Information | |||||
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Drug ID |
D0I7GE
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Former ID |
DNC004772
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Drug Name |
ALPHA-NAPHTHOFLAVONE
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [527386] | ||
Structure |
Download2D MOL |
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Formula |
C19H12O2
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Canonical SMILES |
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
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InChI |
1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
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InChIKey |
VFMMPHCGEFXGIP-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Cytochrome P450 19 | Target Info | Inhibitor | [530867] | |
DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [527386] | ||
NetPath Pathway | FSH Signaling PathwayNetPath_13:IL1 Signaling Pathway | ||||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
WikiPathways | Metapathway biotransformation | ||||
Tryptophan metabolism | |||||
Oxidation by Cytochrome P450 | |||||
Ovarian Infertility Genes | |||||
Metabolism of steroid hormones and vitamin D | |||||
FSH signaling pathway | |||||
Integrated Breast Cancer Pathway | |||||
Phase 1 - Functionalization of compoundsWP707:DNA Damage Response | |||||
Non-homologous end joining | |||||
FAS pathway and Stress induction of HSP regulation | |||||
Cytosolic sensors of pathogen-associated DNA | |||||
Retinoblastoma (RB) in Cancer | |||||
Prostate Cancer | |||||
Double-Strand Break Repair | |||||
Cell Cycle | |||||
miRNA Regulation of DNA Damage Response | |||||
References | |||||
Ref 527386 | J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | ||||
Ref 530867 | Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. Epub 2010 Apr 8.Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). |
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