Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0FS9K
|
||||
| Former ID |
DIB003157
|
||||
| Drug Name |
MINAMESTANE
|
||||
| Synonyms |
FCE-24928; Minamestane < Rec INN >; 4-Aminoandrosta-1,4,6-triene-3,17-dione
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Bladder cancer [ICD9: 188; ICD10:C67] | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H23NO2
|
||||
| Canonical SMILES |
C[C@]12CC[C@H]3[C@@H](C=CC4=C(N)C(=O)C=C[C@]34C)[C@@H]1<br />CCC2=O
|
||||
| InChI |
1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
|
||||
| InChIKey |
DAKHYLIFCYPHQW-KZQROQTASA-N
|
||||
| CAS Number |
CAS 105051-87-4
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cytochrome P450 19 | Target Info | Inhibitor | [2], [3] | |
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Estradiol biosynthesis II | |||||
| Estradiol biosynthesis I | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| Ovarian steroidogenesis | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
| PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
| Reactome | Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | ||||
| Tryptophan metabolism | |||||
| Oxidation by Cytochrome P450 | |||||
| Ovarian Infertility Genes | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| FSH signaling pathway | |||||
| Integrated Breast Cancer Pathway | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002545) | ||||
| REF 2 | High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma. J Chromatogr A. 1994 Feb 4;660(1-2):293-8. | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.