| Drug General Information |
| Drug ID |
D0L1JF
|
| Former ID |
DNC004701
|
| Drug Name |
3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H12FN
|
| Canonical SMILES |
C1CC2=C(C1=CC3=CN=CC=C3)C=CC=C2F
|
| InChI |
1S/C15H12FN/c16-15-5-1-4-13-12(6-7-14(13)15)9-11-3-2-8-17-10-11/h1-5,8-10H,6-7H2/b12-9-
|
| InChIKey |
JKDSUQNXZNYUED-XFXZXTDPSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|---|
| 17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
|
Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
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Glucocorticoid biosynthesis
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Androgen biosynthesis
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KEGG Pathway
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Steroid hormone biosynthesis
|
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Metabolic pathways
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Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
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Ovarian steroidogenesis
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Prolactin signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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Androgen and Estrogen MetabolismPW000045:Androgen and Estrogen Metabolism
|
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Steroidogenesis
|
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Reactome
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Endogenous sterolsR-HSA-193048:Androgen biosynthesis
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Glucocorticoid biosynthesis
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Endogenous sterols
|
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WikiPathways
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Metapathway biotransformation
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Tryptophan metabolism
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Oxidation by Cytochrome P450
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Ovarian Infertility Genes
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Metabolism of steroid hormones and vitamin D
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
|
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Steroid Biosynthesis
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Glucocorticoid & Mineralcorticoid Metabolism
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Prostate Cancer
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Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. |
|---|
