Drug Information

Drug General Information
Drug ID
D0Y6OA
Former ID
DNC003732
Drug Name
COUMATE
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 2 [531371]
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) Carbonic anhydrase IV Target Info Inhibitor [529605]
Carbonic anhydrase Target Info Inhibitor [529605]
Carbonic anhydrase I Target Info Inhibitor [529605]
Carbonic anhydrase XIV Target Info Inhibitor [529605]
Carbonic anhydrase IX Target Info Inhibitor [529605]
Carbonic anhydrase VI Target Info Inhibitor [529605]
Steryl-sulfatase Target Info Inhibitor [530712]
Carbonic anhydrase XII Target Info Inhibitor [529605]
Cytochrome P450 19 Target Info Inhibitor [530712]
Carbonic anhydrase II Target Info Inhibitor [529605]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00140:Steroid hormone biosynthesishsa00910:Nitrogen metabolismhsa00140:Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesishsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
Pathway Interaction Database C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway Gastric Acid ProductionPW000045:Androgen and Estrogen MetabolismPW000045:Androgen and Estrogen Metabolism
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1660662:Glycosphingolipid metabolismR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-211976:Endogenous sterolsR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP697:Estrogen metabolism
Vitamin D Receptor Pathway
Sphingolipid metabolismWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP702:Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compoundsWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 531371Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. Expert Rev Anticancer Ther. 2011 Feb;11(2):179-83.
Ref 529605Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. Epub 2008 Jul 5.Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Ref 530712J Med Chem. 2010 Mar 11;53(5):2155-70.Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.

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