| Drug General Information |
| Drug ID |
D00HVZ
|
| Former ID |
DNC007437
|
| Drug Name |
(+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one
|
| Synonyms |
7-methoxy-2-(4-methoxyphenyl)chroman-4-one
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(C=C3)OC
|
| InChI |
1S/C17H16O4/c1-19-12-5-3-11(4-6-12)16-10-15(18)14-8-7-13(20-2)9-17(14)21-16/h3-9,16H,10H2,1-2H3
|
| InChIKey |
YAEYGSBLDUIDTP-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 19 |
Target Info |
Inhibitor |
[2]
|
|---|
| Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
|
Estradiol biosynthesis IPWY66-401:Superpathway of tryptophan utilization
|
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Tryptophan degradation via tryptamine
|
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Dopamine degradation
|
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Putrescine degradation III
|
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Noradrenaline and adrenaline degradation
|
|
KEGG Pathway
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Steroid hormone biosynthesis
|
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Metabolic pathways
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Ovarian steroidogenesishsa00260:Glycine, serine and threonine metabolism
|
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Arginine and proline metabolism
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Histidine metabolism
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Tyrosine metabolism
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Phenylalanine metabolism
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Tryptophan metabolism
|
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Drug metabolism - cytochrome P450
|
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Serotonergic synapse
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Dopaminergic synapse
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Cocaine addiction
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Amphetamine addiction
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Alcoholism
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NetPath Pathway
|
FSH Signaling Pathway
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PANTHER Pathway
|
Androgen/estrogene/progesterone biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
|
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5-Hydroxytryptamine degredation
|
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Dopamine receptor mediated signaling pathway
|
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Pathway Interaction Database
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Alpha-synuclein signaling
|
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PathWhiz Pathway
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Androgen and Estrogen Metabolism
|
|
Reactome
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Endogenous sterols
|
|
WikiPathways
|
Metapathway biotransformation
|
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Tryptophan metabolism
|
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Oxidation by Cytochrome P450
|
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Ovarian Infertility Genes
|
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Metabolism of steroid hormones and vitamin D
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FSH signaling pathway
|
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compoundsWP465:Tryptophan metabolism
|
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Dopamine metabolism
|
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Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | Bioorg Med Chem. 2010 Feb;18(3):1273-9. Epub 2010 Jan 4.A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. |
|---|
| REF 2 | J Med Chem. 2007 Jun 14;50(12):2799-806. Epub 2007 May 19.Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. |
|---|
