Target Validation Information
Target ID T43920
Target Name Carbonic anhydrase
Target Type
Successful
Drug Potency against Target 3-Amino-benzenesulfonamide Drug Info Ki = 1240 nM [527292]
SULFAMATE Drug Info Ki = 9500 nM [528141]
4-azidobenzenesulfonamide Drug Info Ki = 55.8 nM [529609]
5-amino-1,3,4-thiadiazole-2-sulfonamide Drug Info Ki = 48 nM [531013]
3-(4-sulfamoylphenyl)propanoic acid Drug Info Ki = 1277 nM [530146]
PHENOL Drug Info Ki = 10500 nM [531068]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid Drug Info Ki = 7600 nM [530514]
Decyl sulfamate Drug Info Ki = 956 nM [530359]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 9000 nM [530514]
Decane-1,10-diyl disulfamate Drug Info Ki = 960 nM [530359]
SPERMINE Drug Info Ki = 710 nM [530998]
2-acetamido-2,3-dihydro-1H-indene-5-sulfonic acid Drug Info Ki = 7.1 nM [529417]
1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info Ki = 910 nM [528240]
4-AMINOPHENOL Drug Info Ki = 9500 nM [529562]
Syringic Acid Drug Info Ki = 8580 nM [530751]
Octyl sulfamate Drug Info Ki = 1125 nM [530359]
Beta-naphthylboronic acid Drug Info Ki = 9300 nM [530086]
4-methoxyphenylboronic acid Drug Info Ki = 15600 nM [530086]
P-tolylboronic acid Drug Info Ki = 9000 nM [530086]
4-nitrophenyl-difluoromethanesulfonamide Drug Info Ki = 153 nM [527782]
2,5-difluorophenol Drug Info Ki = 10800 nM [529562]
PARABEN Drug Info Ki = 6610 nM [530751]
4-methylphenyl-difluoromethanesulfonamide Drug Info Ki = 128 nM [527782]
Dichlorphenamide Drug Info EC50 = 2500 nM [552597]
COUMARIN Drug Info Ki = 5600 nM [530514]
SACCHARIN Drug Info Ki = 792 nM [530466]
4-butylphenylboronic acid Drug Info Ki = 8000 nM [530086]
4-phenoxyphenylboronic acid Drug Info Ki = 8600 nM [530086]
PHENYLMETHANESULFONAMIDE Drug Info Ki = 1580 nM [527782]
4-(2-Amino-ethyl)-benzenesulfonamide Drug Info Ki = 43 nM [527408]
4-(2-Phenylacetamidoethyl)benzenesulfonamide Drug Info Ki = 8.2 nM [530219]
2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 6600 nM [530514]
(4-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 982 nM [527782]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 9300 nM [529794]
4-Nitro-benzenesulfonamide Drug Info IC50 = 4200 nM [527253]
2-hydrazinylbenzenesulfonamide Drug Info Ki = 6895 nM [529948]
3-bromophenyl-difluoromethanesulfonamide Drug Info Ki = 160 nM [527782]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide Drug Info Ki = 6.8 nM [530219]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide Drug Info Ki = 5.9 nM [530219]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 2900 nM [529794]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide Drug Info Ki = 7 nM [530219]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide Drug Info Ki = 8.1 nM [530219]
3,5-difluorophenol Drug Info Ki = 11300 nM [529489]
4-Hydrazino-benzenesulfonamide Drug Info Ki = 9540 nM [529948]
CLIOQUINOL Drug Info Ki = 2330 nM [529489]
SALICYLATE Drug Info Ki = 7200 nM [529489]
2,3-dihydro-1H-indene-5-sulfonamide Drug Info Ki = 5.1 nM [529417]
COUMATE Drug Info Ki = 1050 nM [529605]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide Drug Info Ki = 8.1 nM [530219]
Phenyl Boronic acid Drug Info Ki = 8300 nM [528141]
4-(2-Phenylacetamidomethyl)benzenesulfonamide Drug Info Ki = 8.3 nM [530219]
PRONTOCIL Drug Info Ki = 2300 nM [529030]
4-amino-3-fluoro-5-iodobenzenesulfonamide Drug Info Ki = 19000 nM [529030]
4-bromophenylboronic acid Drug Info Ki = 15900 nM [530086]
4-nitrophenyl phosphate Drug Info IC50 = 1050 nM [531156]
Acetazolamide Drug Info Ki = 1.8 nM [552703]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 1700 nM [530514]
Carzenide Drug Info Ki = 4650 nM [529948]
4-(2-Hydroxy-ethyl)-benzenesulfonamide Drug Info Ki = 4660 nM [529948]
RESORCINOL Drug Info Ki = 8700 nM [529562]
INDISULAM Drug Info Ki = 72 nM [529948]
4-Amino-3-bromo-benzenesulfonamide Drug Info Ki = 83 nM [529948]
BENZOLAMIDE Drug Info Ki = 70 nM [529948]
Hexane-1,6-diamine Drug Info Ki = 660 nM [530998]
6-(hydroxymethyl)-2H-chromen-2-one Drug Info Ki = 4700 nM [530514]
4-Amino-3-fluoro-benzenesulfonamide Drug Info Ki = 79 nM [529948]
4-(hydroxymethyl)benzenesulfonamide Drug Info Ki = 4560 nM [529948]
Phenylarsonic acid Drug Info Ki = 12500 nM [528141]
Sodium maleate Drug Info Ki = 8600 nM [530027]
4-amino-3,5-dibromobenzenesulfonamide Drug Info Ki = 10700 nM [529030]
(2-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 714 nM [527782]
CATECHIN Drug Info Ki = 7680 nM [531068]
ELLAGIC ACID Drug Info Ki = 10300 nM [530751]
Pentane-1,5-diamine Drug Info Ki = 650 nM [530998]
Curcumin Drug Info Ki = 5090 nM [531068]
P-Coumaric Acid Drug Info Ki = 7570 nM [530751]
CATECHOL Drug Info Ki = 13000 nM [530751]
ETHOXYCOUMARIN Drug Info Ki = 9000 nM [530514]
7-propoxy-2H-chromen-2-one Drug Info Ki = 8600 nM [530514]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 7500 nM [529794]
4-CYANOPHENOL Drug Info Ki = 6700 nM [529562]
2,4-Disulfamyltrifluoromethylaniline Drug Info Ki = 926 nM [529948]
4-Amino-3-iodo-benzenesulfonamide Drug Info Ki = 72 nM [529948]
PARAOXON Drug Info IC50 = 1021 nM [531156]
4-Thiocyanato-benzenesulfonamide Drug Info IC50 = 8600 nM [527253]
Biphenyl-4-ylboronic acid Drug Info Ki = 7800 nM [530086]
2-Amino-indan-5-sulfonic acid Drug Info Ki = 8 nM [529417]
N1-(2-aminoethyl)ethane-1,2-diamine Drug Info Ki = 11500 nM [530998]
4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info Ki = 757 nM [529948]
4-(2-Phenylacetamido)benzenesulfonamide Drug Info Ki = 7.9 nM [530219]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide Drug Info Ki = 9 nM [530219]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 18700 nM [529794]
2-oxo-2H-thiochromene-3-carboxylic acid Drug Info Ki = 7700 nM [530514]
4-Amino-3-chloro-benzenesulfonamide Drug Info Ki = 62 nM [529948]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide Drug Info Ki = 8 nM [530219]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 2800 nM [529794]
7-phenethoxy-2H-chromen-2-one Drug Info Ki = 9000 nM [530514]
2-Amino-benzenesulfonamide Drug Info Ki = 8805 nM [529948]
FERULIC ACID Drug Info Ki = 11100 nM [530751]
6-(aminomethyl)-2H-chromen-2-one Drug Info Ki = 8600 nM [530514]
PHENYLDIFLUOROMETHANESULFONAMIDE Drug Info Ki = 785 nM [527782]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide Drug Info Ki = 67 nM [529948]
MAFENIDE Drug Info Ki = 970 nM [529948]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate Drug Info Ki = 9700 nM [530514]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 49 nM [529948]
6-Hydroxy-benzothiazole-2-sulfonic acid amide Drug Info Ki = 64 nM [529948]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 17700 nM [530514]
P-TOLUENESULFONAMIDE Drug Info Ki = 7990 nM [529948]
3-Nitro-benzenesulfonamide Drug Info IC50 = 780 nM [527253]
GALLICACID Drug Info Ki = 7490 nM [530751]
Octane-1,8-diyl disulfamate Drug Info Ki = 569 nM [530359]
SULFAMIDE Drug Info Ki = 6800 nM [530922]
Benzothiazole-2-sulfonic acid amide Drug Info Ki = 4 nM [527408]
N1-(naphthalen-1-yl)ethane-1,2-diamine Drug Info Ki = 570 nM [530998]
2-amino-2,3-dihydro-1H-indene-5-sulfonamide Drug Info Ki = 1.6 nM [529417]
7-butoxy-2H-chromen-2-one Drug Info Ki = 7300 nM [530514]
HERNIARIN Drug Info Ki = 5100 nM [530514]
7-(benzyloxy)-2H-chromen-2-one Drug Info Ki = 8100 nM [530514]
References
Ref 527292Bioorg Med Chem Lett. 2004 Dec 20;14(24):6001-6.Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Ref 528141Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Ref 529609Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
Ref 531013Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. Epub 2010 Jun 17.Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamideresides in a less utilized binding pocket than most hydrophobic inhibitors.
Ref 530146Bioorg Med Chem. 2009 Jul 1;17(13):4503-9. Epub 2009 May 8.Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Ref 531068Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530359J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530359J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 529417Eur J Med Chem. 2008 Dec;43(12):2853-60. Epub 2008 Feb 29.Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
Ref 528240Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Ref 529562Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530359J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 529562Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 552597Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530466Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 527408Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 527253Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 529489Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. Epub 2008 May 4.Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529489Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. Epub 2008 May 4.Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Ref 529489Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. Epub 2008 May 4.Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Ref 529417Eur J Med Chem. 2008 Dec;43(12):2853-60. Epub 2008 Feb 29.Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
Ref 529605Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. Epub 2008 Jul 5.Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 528141Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 529030Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. Epub 2007 Aug 25.Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Ref 529030Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. Epub 2007 Aug 25.Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 531156Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases.
Ref 552703Carbonic anhydrase inhibitors as anticonvulsant agents. Curr Top Med Chem. 2007;7(9):855-64.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529562Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 528141Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Ref 530027Bioorg Med Chem. 2009 Apr 1;17(7):2654-7. Epub 2009 Mar 5.Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates.
Ref 529030Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. Epub 2007 Aug 25.Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 531068Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 531068Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 529562Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 531156Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases.
Ref 527253Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 529417Eur J Med Chem. 2008 Dec;43(12):2853-60. Epub 2008 Feb 29.Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530219Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 527782Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 529948J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 527253Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Ref 530359J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Ref 530922Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
Ref 527408Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 529417Eur J Med Chem. 2008 Dec;43(12):2853-60. Epub 2008 Feb 29.Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.