| Drug General Information |
| Drug ID |
D0LD9S
|
| Former ID |
DNC010766
|
| Drug Name |
SPERMINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Terminated |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H26N4
|
| InChI |
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
|
| InChIKey |
PFNFFQXMRSDOHW-UHFFFAOYSA-N
|
| CAS Number |
CAS 71-44-3
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4012, 140612, 585338, 600883, 826607, 855222, 3134394, 5612034, 7890561, 7980642, 8143356, 8150975, 10317955, 10533682, 11111791, 11113818, 11439632, 11446854, 14748726, 24439454, 24888220, 24899550, 24899594, 26701763, 26701869, 26704188, 26704193, 26704197, 26704245, 26704375, 26704579, 26705140, 26705170, 26705322, 26705370, 26705680, 26706947, 26706956, 26709511, 26710174, 26711528, 26712356, 26712786, 26713080, 26713117, 26713121, 26713142, 26713516, 26713534, 26713537
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[3]
|
|---|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[4]
|
| Carbonic anhydrase IV |
Target Info |
Inhibitor |
[4]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[3]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[4]
|
| Carbonic anhydrase VI |
Target Info |
Inhibitor |
[4]
|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[4]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Glutamatergic synapse
|
|
Dopaminergic synapse
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Cocaine addiction
|
|
Amphetamine addiction
|
|
Nicotine addiction
|
|
Alcoholism
|
|
Systemic lupus erythematosushsa00910:Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamationhsa04014:Ras signaling pathway
|
|
Huntington's disease
|
|
Alcoholismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
PANTHER Pathway
|
Huntington disease
|
|
Ionotropic glutamate receptor pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Pathway Interaction Database
|
Reelin signaling pathwayhif1_tfpathway:HIF-1-alpha transcription factor network
|
|
Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
|
|
CREB phosphorylation through the activation of CaMKII
|
|
Ras activation uopn Ca2+ infux through NMDA receptor
|
|
RAF/MAP kinase cascadeR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
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Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxideR-HSA-3928662:EPHB-mediated forward signaling
|
|
RAF/MAP kinase cascadeR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
|
|
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Alzheimers DiseaseWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
|
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP706:SIDS Susceptibility Pathways
|
|
Spinal Cord Injury
|
|
BDNF signaling pathway
|
|
Alzheimers DiseaseWP2877:Vitamin D Receptor Pathway
|
|
Reversible Hydration of Carbon Dioxide
|
|
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 710). |
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| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008464) |
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| REF 3 | J Med Chem. 2010 May 13;53(9):3611-7.Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
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| REF 4 | J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. |
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