| Drug General Information |
| Drug ID |
D00RNZ
|
| Former ID |
DNC010064
|
| Drug Name |
7-(benzyloxy)-2H-chromen-2-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H12O3
|
| Canonical SMILES |
C1=CC=C(C=C1)COC2=CC3=C(C=C2)C=CC(=O)O3
|
| InChI |
1S/C16H12O3/c17-16-9-7-13-6-8-14(10-15(13)19-16)18-11-12-4-2-1-3-5-12/h1-10H,11H2
|
| InChIKey |
QDLFCBKKECTJSK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase IV |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
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NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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Pathway Interaction Database
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HIF-1-alpha transcription factor network
|
|
Reactome
|
Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
|
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
|
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WikiPathways
|
Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
|
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
|
miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBase
|
| References |
| REF 1 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. |
|---|
