Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T13201 | ||||
Target Name | Carbonic anhydrase I | ||||
Target Type | Successful |
||||
Drug Potency against Target | N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide | Drug Info | Ki = 40 nM | ||
BENZOLAMIDE | Drug Info | Ki = 15 nM | [537461] | ||
3-(4-sulfamoylphenyl)propanoic acid | Drug Info | Ki = 6690 nM | [537461] | ||
GALLICACID | Drug Info | Ki = 3200 nM | [530751] | ||
Phenoxyarsonous acid | Drug Info | Ki = 31.7 nM | [527231] | ||
5-Chlorosalicylic Acid | Drug Info | Ki = 4160 nM | [529721] | ||
4,6-Dinitro salicylic acid | Drug Info | Ki = 14850 nM | [529721] | ||
4-azidobenzenesulfonamide | Drug Info | Ki = 3900 nM | [529609] | ||
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | Drug Info | Ki = 164 nM | [537461] | ||
PHENOL | Drug Info | Ki = 10200 nM | [531068] | ||
P-Coumaric Acid | Drug Info | Ki = 1070 nM | [530751] | ||
PARABEN | Drug Info | Ki = 920 nM | [530751] | ||
4-(Methylhydrazino)-3-pyridinesulfonamide | Drug Info | Ki = 5620 nM | [530766] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide | Drug Info | Ki = 10000 nM | [528653] | ||
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide | Drug Info | Ki = 74 nM | [528406] | ||
4-isothiocyanatobenzenesulfonamide | Drug Info | Ki = 5000 nM | [527233] | ||
Phenyl Boronic acid | Drug Info | Ki = 58.6 nM | [527231] | ||
CHLORIDE | Drug Info | Ki = 6 nM | [527231] | ||
NSC-654077 | Drug Info | Ki = 4350 nM | [529381] | ||
SALICYLATE | Drug Info | Ki = 9900 nM | [529562] | ||
Syringic Acid | Drug Info | Ki = 4150 nM | [530751] | ||
4-bromophenylboronic acid | Drug Info | Ki = 11700 nM | [530086] | ||
IODIDE | Drug Info | Ki = 0.3 nM | [527231] | ||
4-nitrophenyl phosphate | Drug Info | IC50 = 330 nM | [531156] | ||
SULFATE | Drug Info | Ki = 63 nM | [527231] | ||
SULFAMIDE | Drug Info | Ki = 0.31 nM | [527231] | ||
4-Amino-3-iodo-benzenesulfonamide | Drug Info | Ki = 6000 nM | [537461] | ||
Azide | Drug Info | Ki = 1200 nM | [527260] | ||
Octyl sulfamate | Drug Info | Ki = 3.5 nM | [530359] | ||
4-methylstyrylboronic acid | Drug Info | Ki = 12100 nM | [530086] | ||
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide | Drug Info | Ki = 36 nM | [527262] | ||
2-Acetylamino-indan-5-sulfonic acid hydrate | Drug Info | Ki = 89 nM | [527262] | ||
2-Amino-indan-5-sulfonic acid | Drug Info | Ki = 43 nM | [527262] | ||
4-Amino-3-chloro-benzenesulfonamide | Drug Info | Ki = 9800 nM | [537461] | ||
N-(pentafluorophenyl)sulfamide | Drug Info | Ki = 34 nM | [527520] | ||
1-cyclohexylamido-5-sulfonamidoindane | Drug Info | Ki = 880 nM | [528160] | ||
N-(4-Sulfamoyl-phenyl)-butyramide | Drug Info | Ki = 19300 nM | [527743] | ||
2-pentafluorophenylamido-5-sulfonamidoindane | Drug Info | Ki = 600 nM | [528160] | ||
SACCHARIN | Drug Info | Ki = 18540 nM | [531031] | ||
2-nonylamido-5-sulfonamidoindane | Drug Info | Ki = 5330 nM | [528160] | ||
2-propylamido-5-sulfonamidoindane | Drug Info | Ki = 825 nM | [528160] | ||
Prop-2-ynyl 4-sulfamoylbenzoate | Drug Info | Ki = 4000 nM | [528491] | ||
Pentanoic acid (4-sulfamoyl-phenyl)-amide | Drug Info | Ki = 17650 nM | [527743] | ||
4-butylphenylboronic acid | Drug Info | Ki = 7900 nM | [530086] | ||
4-methylphenyl-difluoromethanesulfonamide | Drug Info | Ki = 952 nM | [527782] | ||
Phenethylboronic acid | Drug Info | Ki = 11400 nM | [530086] | ||
Biphenyl-4-ylboronic acid | Drug Info | Ki = 3700 nM | [530086] | ||
Styrylboronic acid | Drug Info | Ki = 12500 nM | [530086] | ||
4-(Quinolinoxy)-3-pyridinesulfonamide | Drug Info | Ki = 10320 nM | [530766] | ||
2,4-Disulfamyltrifluoromethylaniline | Drug Info | Ki = 5800 nM | [537461] | ||
4-(4-Fluorophenoxy)-3-pyridinesulfonamide | Drug Info | Ki = 9160 nM | [530766] | ||
4-amino-6-chlorobenzene-1,3-disulfonamide | Drug Info | Ki = 8400 nM | [531031] | ||
2-butylamido-5-sulfonamidoindane | Drug Info | Ki = 875 nM | [528160] | ||
2-acetamido-5-sulfonamidoindane | Drug Info | Ki = 2510 nM | [528160] | ||
4-Hydrazino-benzenesulfonamide | Drug Info | Ki = 3900 nM | [527482] | ||
3-Chloro-4-hydrazino-benzenesulfonamide | Drug Info | Ki = 2800 nM | [527482] | ||
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide | Drug Info | Ki = 10300 nM | [530766] | ||
N-(4-Sulfamoyl-phenyl)-propionamide | Drug Info | Ki = 19700 nM | [527743] | ||
4-Methoxy-3-pyridinesulfonamide | Drug Info | Ki = 7340 nM | [530766] | ||
Sulfamic acid 4-sulfamoyloxy-butyl ester | Drug Info | Ki = 31 nM | [527391] | ||
4-nitrophenyl-difluoromethanesulfonamide | Drug Info | Ki = 1130 nM | [527782] | ||
PHENYLMETHANESULFONAMIDE | Drug Info | Ki = 1250 nM | [527782] | ||
N-(4-Sulfamoyl-phenyl)-benzamide | Drug Info | Ki = 3300 nM | [527743] | ||
Sulfamic acid 6-sulfamoyloxy-hexyl ester | Drug Info | Ki = 136 nM | [527391] | ||
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide | Drug Info | Ki = 68 nM | [530219] | ||
2,3-dihydro-1H-indene-5-sulfonamide | Drug Info | Ki = 215 nM | [527262] | ||
4-Methylthiopyridine-3-sulfonamide | Drug Info | Ki = 9030 nM | [530766] | ||
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide | Drug Info | Ki = 430 nM | [527743] | ||
4-Benzythiopyridine-3-sulfonamide | Drug Info | Ki = 9090 nM | [530766] | ||
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info | Ki = 2400 nM | [529794] | ||
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 7010 nM | [529794] | ||
2-cyclohexylamido-5-sulfonamidoindane | Drug Info | Ki = 3560 nM | [528160] | ||
1-acetamido-5-sulfonamidoindane | Drug Info | Ki = 8.5 nM | [527262] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide | Drug Info | Ki = 10200 nM | [528653] | ||
6-(aminomethyl)-2H-chromen-2-one | Drug Info | Ki = 99 nM | [530514] | ||
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester | Drug Info | Ki = 16450 nM | [527391] | ||
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide | Drug Info | Ki = 263 nM | [530219] | ||
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide | Drug Info | Ki = 10320 nM | [530766] | ||
4-(Carbamolymethylthio)pyridine-3-sulfonamide | Drug Info | Ki = 9510 nM | [530766] | ||
5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate | Drug Info | Ki = 730 nM | [530979] | ||
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide | Drug Info | Ki = 71 nM | [530219] | ||
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info | Ki = 1890 nM | [529794] | ||
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide | Drug Info | Ki = 4120 nM | [530978] | ||
4-(2-Phenylacetamidomethyl)benzenesulfonamide | Drug Info | Ki = 75 nM | [530219] | ||
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide | Drug Info | Ki = 61 nM | [530219] | ||
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide | Drug Info | Ki = 67 nM | [530219] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide | Drug Info | Ki = 9800 nM | [528653] | ||
4-(Cyanomethylthio)pyridine-3-sulfonamide | Drug Info | Ki = 11710 nM | [530766] | ||
4-(Allylamino)-3-pyridinesulfonamide | Drug Info | Ki = 8860 nM | [530766] | ||
4-[2-(2-Thienyl)acetamido]benzenesulfonamide | Drug Info | Ki = 61 nM | [530219] | ||
4-Amino-3-fluoro-benzenesulfonamide | Drug Info | Ki = 8300 nM | [531031] | ||
[Cu(CN)2]- | Drug Info | Ki = 6900 nM | [527492] | ||
Sodium trithiocarbonate | Drug Info | Ki = 8700 nM | [530003] | ||
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide | Drug Info | Ki = 4500 nM | [527519] | ||
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide | Drug Info | Ki = 109 nM | [537461] | ||
PHENYLDIFLUOROMETHANESULFONAMIDE | Drug Info | Ki = 357 nM | [527782] | ||
4-ethynyl benzene sulfonamide | Drug Info | Ki = 1080 nM | [529344] | ||
2-(biphenyl-4-yl)vinylboronic acid | Drug Info | Ki = 10700 nM | [530086] | ||
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide | Drug Info | Ki = 48 nM | [530132] | ||
N-hydroxysulfamide | Drug Info | Ki = 4050 nM | [530922] | ||
PARAOXON | Drug Info | IC50 = 338 nM | [531156] | ||
[Au(CN)2]- | Drug Info | Ki = 7700 nM | [527492] | ||
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide | Drug Info | Ki = 9.6 nM | [527338] | ||
5-amino-1,3,4-thiadiazole-2-sulfonamide | Drug Info | Ki = 5900 nM | [531112] | ||
4-(2-Amino-ethyl)-benzenesulfonamide | Drug Info | Ki = 2100 nM | [527645] | ||
4-(hydroxymethyl)benzenesulfonamide | Drug Info | Ki = 55 nM | [537461] | ||
3-Fluoro-4-hydrazino-benzenesulfonamide | Drug Info | Ki = 3300 nM | [527482] | ||
NITRATE | Drug Info | Ki = 7 nM | [527231] | ||
Pentane-1,5-diamine | Drug Info | Ki = 13300 nM | [530998] | ||
Octane-1,8-diyl disulfamate | Drug Info | Ki = 378 nM | [530359] | ||
2-oxo-2H-thiochromene-3-carboxylic acid | Drug Info | Ki = 12400 nM | [530514] | ||
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 5540 nM | [529794] | ||
HERNIARIN | Drug Info | Ki = 5900 nM | [530514] | ||
Decane-1,10-diyl disulfamate | Drug Info | Ki = 890 nM | [530359] | ||
Sulfamic acid 12-sulfamoyloxy-dodecyl ester | Drug Info | Ki = 1350 nM | [527391] | ||
Aminobenzolamide derivative | Drug Info | Ki = 62 nM | [527261] | ||
HYDROSULFIDE | Drug Info | Ki = 600 nM | [527260] | ||
N-1,3,4-thiadiazol-2-ylsulfamide | Drug Info | Ki = 7420 nM | [529794] | ||
CYANATE | Drug Info | Ki = 700 nM | [527260] | ||
Carzenide | Drug Info | Ki = 3400 nM | [530046] | ||
Curcumin | Drug Info | Ki = 2410 nM | [531068] | ||
Cynooxide anion | Drug Info | Ki = 700 nM | [527211] | ||
Decyl sulfamate | Drug Info | Ki = 530 nM | [530359] | ||
4-methoxyphenylboronic acid | Drug Info | Ki = 10900 nM | [530086] | ||
4-phenoxyphenylboronic acid | Drug Info | Ki = 6000 nM | [530086] | ||
Beta-naphthylboronic acid | Drug Info | Ki = 6500 nM | [530086] | ||
3-phenylprop-1-enylboronic acid | Drug Info | Ki = 8600 nM | [530086] | ||
Carbamoyl phosphate disodium | Drug Info | Ki = 9400 nM | [527259] | ||
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide | Drug Info | Ki = 14600 nM | [527743] | ||
4-(2-Phenylacetamidoethyl)benzenesulfonamide | Drug Info | Ki = 60 nM | [530219] | ||
(4-bromophenyl)difluoromethanesulfonamide | Drug Info | Ki = 273 nM | [527782] | ||
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 1660 nM | [529794] | ||
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide | Drug Info | Ki = 75 nM | [530219] | ||
4-(2-Phenylacetamido)benzenesulfonamide | Drug Info | Ki = 108 nM | [530219] | ||
2-Hydroxycinnamic acid | Drug Info | Ki = 3100 nM | [531068] | ||
CATECHIN | Drug Info | Ki = 2420 nM | [531068] | ||
INDISULAM | Drug Info | Ki = 31 nM | [530978] | ||
ELLAGIC ACID | Drug Info | Ki = 2320 nM | [530751] | ||
Hexane-1,6-diamine | Drug Info | Ki = 12600 nM | [530998] | ||
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide | Drug Info | Ki = 870 nM | [529884] | ||
3-bromophenyl-difluoromethanesulfonamide | Drug Info | Ki = 1095 nM | [527782] | ||
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide | Drug Info | Ki = 7620 nM | [530766] | ||
N-propynyl amidebenzenesulphonide | Drug Info | Ki = 6100 nM | [528491] | ||
2-valproylamido-5-sulfonamidoindane | Drug Info | Ki = 4130 nM | [528160] | ||
1-valproylamido-5-sulfonamidoindane | Drug Info | Ki = 810 nM | [528160] | ||
N-(4-cyanophenyl)sulfamide | Drug Info | Ki = 20 nM | [527520] | ||
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 66 nM | [530514] | ||
2-ethylamido-5-sulfonamidoindane | Drug Info | Ki = 3440 nM | [528160] | ||
COUMARIN | Drug Info | Ki = 3100 nM | [531259] | ||
6-Hydroxy-benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 95 nM | [529948] | ||
4-(4-Cyanophenoxy)-3-pyridinesulfonamide | Drug Info | Ki = 6640 nM | [530766] | ||
4-Ethoxy-3-pyridinesulfonamide | Drug Info | Ki = 6100 nM | [530766] | ||
Sulfamic acid 3-sulfamoyloxy-phenyl ester | Drug Info | Ki = 79 nM | [527391] | ||
PHENYLSULFAMATE | Drug Info | Ki = 2.1 nM | [527782] | ||
(2-bromophenyl)difluoromethanesulfonamide | Drug Info | Ki = 5200 nM | [527782] | ||
5-Amino-[1,3,4]thiadiazole-2-thiol | Drug Info | Ki = 7100 nM | [527519] | ||
4-Benzenesulfonylamino-benzenesulfonamide | Drug Info | Ki = 103 nM | [527743] | ||
Sulfamic acid 7-sulfamoyloxy-heptyl ester | Drug Info | Ki = 145 nM | [527391] | ||
1-pentafluorophenylamido-5-sulfonamidoindane | Drug Info | Ki = 770 nM | [528160] | ||
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide | Drug Info | Ki = 276 nM | [529381] | ||
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | Drug Info | Ki = 510 nM | [530979] | ||
4-Methanesulfonylamino-benzenesulfonamide | Drug Info | Ki = 125 nM | [527743] | ||
BENZENESULFONAMIDE | Drug Info | Ki = 3300 nM | [530046] | ||
2,4-dichloro-5-sulfamoylbenzoic acid | Drug Info | IC50 = 7700 nM | [530578] | ||
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide | Drug Info | Ki = 3440 nM | [530978] | ||
COUMATE | Drug Info | Ki = 3450 nM | [529605] | ||
FERULIC ACID | Drug Info | Ki = 2890 nM | [530751] | ||
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 59 nM | [530514] | ||
6-methyl-2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 6800 nM | [530514] | ||
N-[4-(trifluoromethyl)phenyl]sulfamide | Drug Info | Ki = 8000 nM | [527520] | ||
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid | Drug Info | Ki = 3720 nM | [530514] | ||
Benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 95 nM | [527408] | ||
6-Amino-benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 70 nM | [525539] | ||
4-Amino-3-bromo-benzenesulfonamide | Drug Info | Ki = 6500 nM | [537461] | ||
4-(2-Propynylthio)pyridine-3-sulfonamide | Drug Info | Ki = 8320 nM | [530766] | ||
3-(3-Phenyl-ureido)-benzenesulfonamide | Drug Info | Ki = 1500 nM | [527743] | ||
2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 9300 nM | [530514] | ||
4-Hydrazino-3-pyridinesulfonamide | Drug Info | Ki = 7910 nM | [530766] | ||
4,4'-thiodipyridine-3-sulfonamide | Drug Info | Ki = 11170 nM | [530766] | ||
References | |||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 529721 | Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. | ||||
Ref 529721 | Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. | ||||
Ref 529609 | Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 528406 | J Med Chem. 2006 Sep 7;49(18):5544-51.Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. | ||||
Ref 527233 | J Med Chem. 2004 Oct 7;47(21):5224-9.Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 529381 | J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. | ||||
Ref 529562 | Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 531156 | Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 527260 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 527520 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528491 | J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530979 | Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. Epub 2010 May 28.A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 527492 | Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13.Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. | ||||
Ref 530003 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. Epub 2009 Feb 26.Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. | ||||
Ref 527519 | Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 529344 | J Med Chem. 2008 Mar 27;51(6):1945-53. Epub 2008 Feb 29.Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530132 | J Med Chem. 2009 Jul 9;52(13):4063-7.Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. | ||||
Ref 530922 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV. | ||||
Ref 531156 | Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases. | ||||
Ref 527492 | Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13.Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. | ||||
Ref 527338 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72.Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. | ||||
Ref 531112 | Eur J Med Chem. 2010 Nov;45(11):4769-73. Epub 2010 Jul 24.Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. | ||||
Ref 527645 | J Med Chem. 2005 Jul 28;48(15):4834-41.Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 530998 | J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527261 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. | ||||
Ref 527260 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 527260 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. | ||||
Ref 530046 | Nat Chem Biol. 2009 May;5(5):341-3. Epub 2009 Mar 29.Ligand-directed tosyl chemistry for protein labeling in vivo. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 527211 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4563-7.Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527259 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7.Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530998 | J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. | ||||
Ref 529884 | Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 528491 | J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 527520 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 531259 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. | ||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527519 | Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 529381 | J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. | ||||
Ref 530979 | Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. Epub 2010 May 28.A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530046 | Nat Chem Biol. 2009 May;5(5):341-3. Epub 2009 Mar 29.Ligand-directed tosyl chemistry for protein labeling in vivo. | ||||
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