Target Information

Target General Infomation
Target ID
T77913
Former ID
TTDS00086
Target Name
Histamine H1 receptor
Gene Name
HRH1
Synonyms
H1 Histamine receptor; Histamine receptor 1; HRH1
Target Type
Successful
Disease Allergic skin disorders [ICD10: L00-L99]
Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10: J00, J30, J31.0, T78.4]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Allergic conjunctivitis [ICD9: 204.0, 372.0, 372.14, 995.3; ICD10: C91.0, H10, H10.45, T78.4]
Allergic disorders; Itching; Nausea [ICD9: 698, 787, 787.0, 995.3; ICD10: L29, R11, T78.4]
Allergic rhinitis; Urticaria [ICD9: 477, 708; ICD10: J30, L50]
Allergy [ICD9: 995.3; ICD10: T78.4]
Asthma [ICD10: J45]
Anxiety disorder; Morning sickness [ICD9: 300, 643.0; ICD10: F40-F42, O21.0]
Allergic rhinitis; Urticaria; Pruritus [ICD9: 477, 708; ICD10: J30, L50]
Anesthesia [ICD9: 338; ICD10: R20.0]
Common cold; Allergies [ICD9: 460, 995.3; ICD10: J00, T78.4]
Depression [ICD9: 311; ICD10: F30-F39]
Dry cough [ICD10: R05]
Hypersensitivity reactions; Coughs; Common colds [ICD10: R05]
Hay fever [ICD9: 477; ICD10: J30]
Hay fever; Allergic rhinitis [ICD9:477, 472.0, 995.3; ICD10: J30, J00, J31.0, T78.4]
Hay fever; Cough [ICD9:477, 786.2; ICD10: J30, R05]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0]
Insomnia; Anxiety disorder [ICD9:307.41, 307.42, 327.0, 780.51, 780.52, 300, 311; ICD10: F51.0, G47.0, F32, F40-F42]
Nasal congestion [ICD9: 478.19; ICD10: J34.89]
Nausea; Vomiting [ICD9: 787, 787.0; ICD10: R11]
Obesity [ICD9: 278; ICD10: E66]
Ocular allergy [ICD9: 360-379; ICD10: H00-H59]
Pruritus [ICD9: 698; ICD10: L29]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Parkinson's disease [ICD9: 332; ICD10: G20]
Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis [ICD10: H10]
Respiratory allergies; Allergic rhinitis [ICD9:460-519, 472.0, 477, 995.3; ICD10: J00-J99, J00, J30, J31.0, T78.4]
Respiratory allergies; Cancer [ICD9:460-519, 140-229; ICD10: J00-J99, C00-C96]
Rhinitis [ICD9: 472.0, 477; ICD10: J00, J30, J31.0]
Respiratory disease [ICD10: J00-J99]
Rhinitis; Urticaria; Allergy [ICD10: J00, J30, J31.0, L50, T78.4]
Seasonal and perennial allergic rhinitis and vasomotor rhinitis [ICD10: J30]
Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10: F51, G47]
Vertigo meniere's disease [ICD9: 386.0, 438.85, 780.4; ICD10: H81, H81.0, R42]
Vertigo's disease; Meniere's disease [ICD10: H81.09]
Unspecified [ICD code not available]
Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
BioChemical Class
GPCR rhodopsin
Target Validation
T77913
UniProt ID
P35367
Sequence
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
Drugs and Mode of Action
Drug(s) (S)-(+)-Dimethindene maleate Drug Info Approved Pruritus [1]
Aceprometazine Drug Info Approved Sleep disorders [2]
Acrivastine Drug Info Approved Allergic rhinitis [3]
Alcaftadine Drug Info Approved Allergic conjunctivitis [4], [5]
Antazoline Drug Info Approved Nasal congestion [6], [7]
Azatadine Drug Info Approved Allergic rhinitis [8], [9]
Azelastine Drug Info Approved Allergic conjunctivitis [10], [11]
Bepotastine Drug Info Approved Allergic rhinitis; Urticaria; Pruritus [10], [12]
Bromodiphenhydramine Drug Info Approved Hay fever; Cough [13], [14], [15]
Brompheniramine Drug Info Approved Allergic rhinitis [16], [17]
Buclizine Drug Info Approved Nausea; Vomiting [18], [19]
Carbinoxamine Drug Info Approved Seasonal and perennial allergic rhinitis and vasomotor rhinitis [15]
Cetirizine Drug Info Approved Allergic rhinitis [3], [20]
Chlophedianol Drug Info Approved Dry cough [15]
Chlorpheniramine Drug Info Approved Allergic rhinitis; Urticaria [21], [22]
Cinnarizine Drug Info Approved Vertigo meniere's disease [23]
Clemastine Drug Info Approved Allergic rhinitis [24], [25]
Cyclizine Drug Info Approved Nausea; Vomiting [26], [27]
Cyproheptadine Drug Info Approved Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis [15]
Desloratadine Drug Info Approved Allergic rhinitis [28], [29]
Dexbrompheniramine Drug Info Approved Hay fever; Allergic rhinitis [30], [31], [15]
Dexchlorpheniramine Maleate Drug Info Approved Rhinitis; Urticaria; Allergy [15]
Dimenhydrinate Drug Info Approved Nausea; Vomiting [32]
Dimethindene Drug Info Approved Respiratory allergies; Allergic rhinitis [1], [15]
Diphenhydramine Drug Info Approved Vertigo's disease; Meniere's disease [15]
Diphenylpyraline Drug Info Approved Allergic rhinitis [33], [34]
Doxepin Drug Info Approved Depression [35], [36]
Doxylamine Drug Info Approved Anxiety disorder; Morning sickness [37], [38]
Emedastine Drug Info Approved Allergic conjunctivitis [10], [39]
Epinastine Drug Info Approved Allergic conjunctivitis [10], [40]
Ergotidine Drug Info Approved Respiratory allergies; Cancer [41], [42], [15]
Ethopropazine Drug Info Approved Parkinson's disease [43], [44]
Fexofenadine Drug Info Approved Allergic rhinitis [45], [3]
Hydroxyzine Drug Info Approved Anxiety disorder [46], [47]
Ketotifen Drug Info Approved Allergic conjunctivitis [10], [48]
Levocabastine Drug Info Approved Allergic conjunctivitis [10], [49]
Levocetirizine dihydrochloride Drug Info Approved Allergic rhinitis [50], [51]
Loratadine Drug Info Approved Allergy [28], [52]
Mepyramine Drug Info Approved Allergy [53], [54]
Mepyramine maleate Drug Info Approved Allergy [53]
Mequitazine Drug Info Approved Allergic rhinitis [55]
Methdilazine Drug Info Approved Allergic rhinitis [56], [57]
Mizolastine Drug Info Approved Allergic rhinitis [58]
Olopatadine Drug Info Approved Allergic conjunctivitis [10], [59]
Oxatomide Drug Info Approved Hay fever [60]
Pemirolast Drug Info Approved Allergic conjunctivitis [10], [61], [15]
Phenindamine Drug Info Approved Common cold; Allergies [62]
Pheniramine Drug Info Approved Hay fever [10], [63]
Promethazine Drug Info Approved Allergic disorders; Itching; Nausea [64], [65]
Propiomazine Drug Info Approved Insomnia; Anxiety disorder [66], [67], [15]
Pyrilamine Maleate Drug Info Approved Headache [60], [68]
Tranilast Drug Info Approved Ocular allergy [10], [69]
Trimeprazine Drug Info Approved Allergic rhinitis [70], [71]
Tripelennamine Drug Info Approved Hypersensitivity reactions; Coughs; Common colds [15]
Triprolidine Drug Info Approved Hay fever [72], [73]
RUPATADINE Drug Info Phase 4 Discovery agent [74]
AC-170 Drug Info Phase 3 Allergic conjunctivitis [75]
Carebastine Drug Info Phase 3 Ocular allergy [10]
Olopatadine Drug Info Phase 3 Ocular allergy [10], [59]
E-4716 Drug Info Phase 2 Respiratory disease [76]
LY-2624803 Drug Info Phase 2 Insomnia [77]
Noberastine Drug Info Phase 2 Asthma [78]
OBE-101 Drug Info Phase 2 Obesity [79]
UCB-35440 Drug Info Phase 2 Rhinitis [80]
Vapitadine Drug Info Phase 2 Allergic skin disorders [81]
Astemizole Drug Info Withdrawn from market Allergic rhinitis [3], [82]
Chlophedianol Drug Info Withdrawn from market Anesthesia [83], [84]
Terfenadine Drug Info Withdrawn from market Allergy [3], [85]
Norastemizole Drug Info Discontinued in Preregistration Discovery agent [86]
GSK835726 Drug Info Discontinued in Phase 2 Allergic rhinitis [87]
HSR-609 Drug Info Discontinued in Phase 2 Rhinitis [88]
Loratadine Drug Info Discontinued in Phase 2 Allergic rhinitis [89]
Mequitamium iodide Drug Info Discontinued in Phase 2 Asthma [90]
ReN-1869 Drug Info Discontinued in Phase 2 Pain [91]
SUN-1334H Drug Info Discontinued in Phase 2 Allergic rhinitis [92]
AZD-1744 Drug Info Discontinued in Phase 1 Asthma [93]
GSK1004723 Drug Info Discontinued in Phase 1 Allergic rhinitis [94]
KA-398 Drug Info Terminated Asthma [95]
Selenotifen Drug Info Terminated Asthma [96]
SUN-1334H Drug Info Investigative Unspecified [97]
Antagonist (+)-cis-H2-PAT Drug Info [98]
(+)-trans-H2-PAT Drug Info [98]
(+/-)-cis-H2-PAT Drug Info [98]
(+/-)-trans-H2-PAT Drug Info [98]
(-)-trans-H2-PAT Drug Info [98]
(S)-(+)-Dimethindene maleate Drug Info [99], [1], [100], [68]
(S)-cetirizine Drug Info [101]
9-OH-risperidone Drug Info [102]
AC-170 Drug Info [103]
Aceprometazine Drug Info [104]
Acrivastine Drug Info [105], [106]
Alcaftadine Drug Info [4]
Antazoline Drug Info [107], [108], [109], [106]
arpromidine Drug Info [110]
Astemizole Drug Info [109], [111]
Azatadine Drug Info [112]
Azelastine Drug Info [60], [113]
Bepotastine Drug Info [114]
Bromodiphenhydramine Drug Info [115]
Brompheniramine Drug Info [116]
BU-E 47 Drug Info [110]
Buclizine Drug Info [117]
Carbinoxamine Drug Info [118]
Carebastine Drug Info [10]
Cetirizine Drug Info [119], [120]
Chlophedianol Drug Info [121]
Chlorpheniramine Drug Info [122], [60], [68]
Cinnarizine Drug Info [123], [124]
Clemastine Drug Info [125], [126]
Cyclizine Drug Info [127], [128], [129]
Cyproheptadine Drug Info [130], [131]
Desloratadine Drug Info [132], [133]
Dexbrompheniramine Drug Info [134]
Dimenhydrinate Drug Info [135], [136]
Dimethindene Drug Info [99], [1], [100], [68]
Diphenhydramine Drug Info [137], [60]
Diphenylpyraline Drug Info [138]
Doxylamine Drug Info [139], [140]
Emedastine Drug Info [141]
Epinastine Drug Info [142]
Fexofenadine Drug Info [119], [132]
GSK1004723 Drug Info [143]
GSK835726 Drug Info [143]
HSR-609 Drug Info [144], [15]
Hydroxyclemastine Drug Info [125], [126]
Hydroxyzine Drug Info [145], [146]
impromidine Drug Info [147]
Ketotifen Drug Info [148], [60]
Levocabastine Drug Info [149], [150]
Levocetirizine dihydrochloride Drug Info [148], [60], [132]
Loratadine Drug Info [151], [152], [153]
Mepyramine Drug Info [120], [154], [53]
Mepyramine maleate Drug Info [120], [154], [53]
Mequitazine Drug Info [155]
Methdilazine Drug Info [156]
Mizolastine Drug Info [157]
Noberastine Drug Info [158]
Olopatadine Drug Info [10]
Oxatomide Drug Info [149], [60]
Pemirolast Drug Info [159]
Phenindamine Drug Info [160]
Pheniramine Drug Info [161]
Promethazine Drug Info [60], [68]
Propiomazine Drug Info [162]
Pyrilamine Maleate Drug Info [60], [68]
ReN-1869 Drug Info [163]
SUN-1334H Drug Info [97]
Terfenadine Drug Info [164], [153]
Tranilast Drug Info [10]
Trimeprazine Drug Info [165]
Tripelennamine Drug Info [166], [167], [168], [169]
Triprolidine Drug Info [170]
Vapitadine Drug Info [171]
[11C]doxepin Drug Info [172]
[11C]pyrilamine Drug Info [173]
Inhibitor 1-(4-p-Tolyl-butyl)-piperidine Drug Info [174]
1-[(Furan-2(5H)-one)-4-methyl]-desloratadine Drug Info [175]
2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine Drug Info [176]
3,3-diphenylpropan-1-amine Drug Info [176]
4,4-Diphenylbutan-1-amine Drug Info [176]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [177]
9-(2-aminoethyl)-9,10-dihydroanthracene Drug Info [176]
9-(2-aminopropyl)-9,10-dihydroanthracene Drug Info [176]
9-(Aminomethyl)-9,10-dihydroanthracene Drug Info [176]
9-Phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine Drug Info [178]
DIMEBOLIN Drug Info [179]
Diphenyl(piperidin-4-yl)methanol Drug Info [174]
Doxepin Drug Info [180]
KF-A6 Drug Info [181]
MDL-28163 Drug Info [182]
N,N-dimethyl-2,2-diphenylethanamine Drug Info [176]
N,N-Dimethyl-3,3-diphenylpropan-1-amine Drug Info [176]
N,N-dimethyl-4,4-diphenylbutan-1-amine Drug Info [176]
N-hydroxycarbamate derivative Drug Info [183]
N-methyl-3,3-diphenylpropan-1-amine Drug Info [176]
N-methyl-4,4-diphenylbutan-1-amine Drug Info [176]
OCTOCLOTHEPIN Drug Info [184]
R-226161 Drug Info [185]
R-dimethindene Drug Info [186]
RUPATADINE Drug Info [182]
VUF-10148 Drug Info [187]
Agonist 2-(2-thiazolyl)ethanamine Drug Info [110]
2-(3-bromophenyl)histamine Drug Info [110]
2-(3-chlorophenyl)histamine Drug Info [110]
2-(3-iodophenyl)histamine Drug Info [110]
2-pyridylethylamine Drug Info [101]
8R-Lisuride Drug Info [188]
dimethylhistaprodifen Drug Info [110]
Ergotidine Drug Info [41]
histaprodifen Drug Info [189]
methylhistaprodifen Drug Info [110]
oxo-arpromidine Drug Info [147]
S-(-)-Lisuride Drug Info [188]
UR-PG131A Drug Info [147]
UR-PG146 Drug Info [147]
UR-PG153 Drug Info [147]
UR-PG55B Drug Info [147]
Modulator AZD-1744 Drug Info [190]
Dexchlorpheniramine Maleate Drug Info [191]
E-4716 Drug Info [76]
Ethopropazine Drug Info [191]
KA-398 Drug Info [173]
LY-2624803 Drug Info [192]
Mequitamium iodide Drug Info [193]
Norastemizole Drug Info
OBE-101 Drug Info [194]
Selenotifen Drug Info [195]
UCB-35440 Drug Info [196]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
REF 1Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9.
REF 2Drug information of Aceprometazine, 2008. eduDrugs.
REF 3Comparative tolerability of second generation antihistamines. Drug Saf. 1999 May;20(5):385-401.
REF 4Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
REF 5(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7587).
REF 6FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018746.
REF 7(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7116).
REF 8FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017601.
REF 9(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7119).
REF 10Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
REF 11(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7121).
REF 12(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7466).
REF 13FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009319.
REF 14(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7132).
REF 15Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
REF 16FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083821.
REF 17(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7133).
REF 18(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7134).
REF 19Drug information of Buclizine, 2008. eduDrugs.
REF 20(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1222).
REF 21FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070797.
REF 22(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6976).
REF 23Drug information of Cinnarizine, 2008. eduDrugs.
REF 24FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073283.
REF 25(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6063).
REF 26FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009495.
REF 27(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7151).
REF 28Desloratadine treatment for intermittent and persistent allergic rhinitis: a review. Clin Ther. 2007 Sep;29(9):1795-802.
REF 29(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7157).
REF 30FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089116.
REF 31(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7588).
REF 32FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040519.
REF 33(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7165).
REF 34Drug information of Diphenylpyraline, 2008. eduDrugs.
REF 35Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
REF 36(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1225).
REF 37FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040167.
REF 38(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7171).
REF 39(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7174).
REF 40(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7176).
REF 41Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
REF 42(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1247).
REF 43Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
REF 44(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7181).
REF 45(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4819).
REF 46FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 085551.
REF 47(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7199).
REF 48(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7206).
REF 49(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1586).
REF 50FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022064.
REF 51(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1214).
REF 52(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7216).
REF 53Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54.
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