Drug Information
| Drug General Information | |||||
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| Drug ID |
D01NJI
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| Former ID |
DAP001400
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| Drug Name |
Mepyramine maleate
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| Synonyms |
Anisopyradamine; Antihist; Enrumay; Histan; Histatex; Histine; Histosol; Minihist; Paramal; Pyma; Pymafed; Pyraninyl; Renstamin; Anthisan maleate; Component of Pyrdex; Diaminide maleate; Dorantamin maleate; Kriptin maleate; Mepiramine maleate; Mepyramine hydrogen maleinate; Mepyramine maleate salt; Midol Maximum Strength PMS; Neoantergan maleate; PYRILAMINE MALEATE; Paraminyl maleate; Prefrin A; Pyra maleate; Pyramal maleate; Pyranilamine m aleate; Pyranilamine maleate; Pyranisamine maleate; Pyrilamine maleate [USAN]; Pyrilamine maleate salt; Stangen maleate; Statomin maleate; Thylogen maleate; P 5514; Component of Endotussin-NN; Histavet-P; Neo-Antergan maleate; Pymafed (TN); Pyra-Maleate; Pyrilamine maleate (USP); Histavet-P (veterinary); PYRILAMINE MALEATE (SEE ALSO PYRILAMINE, CAS 91-84-9); N-Dimethylaminoethyl-N-p-methoxy-alpha-aminopyridine maleate; N-(dimethylaminoethyl)-N-(p-methoxyphenyl)-alpha-aminopyridine maleate; N-(Dimethylamino)ethyl-N-(p-methoxy)-.alpha.-aminopyridine maleate; N-p-Methoxybenzyl-N',N'-dimethyl-N-alpha-pyridylethylenediamine maleate; Pyridine, 2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]-, maleate (1:1); N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyridyl)ethylenediamine maleate; N-(p-me thoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine maleate; N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine maleate; Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, maleate (1:1); N-(4-Methoxyphenyl)methyl-N inverted exclamation marka,Ninverted exclamation marka-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-.alpha.-pyridylethylenediamine maleate; N-(p-Methoxybenzyl)-N,N'-dimethyl-N-2-pyridyl-1,2-ethanediamine, maleic acid salt; N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine; N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt; N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine but-2-enedioate; N,N-dimethyl-N'-{[4-(methyloxy)phenyl]methyl}-N'-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate; (Z)-but-2-enedioic acid; 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-, (Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-, (Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N1-((4-methoxyphenyl)methyl)-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1); 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine bimaleate; 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate; 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate (1:1); 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine bimaleate; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine maleate; 2786 R.P. maleate
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| Drug Type |
Small molecular drug
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| Indication | Allergy [ICD9: 995.3; ICD10:T78.4] | Approved | [1] | ||
| Therapeutic Class |
Antiasthmatic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C21H27N3O5
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| Canonical SMILES |
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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| InChIKey |
JXYWFNAQESKDNC-BTJKTKAUSA-N
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| CAS Number |
CAS 59-33-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
70057, 855902, 8149511, 10321599, 11039284, 17405449, 24277797, 26611903, 26680596, 26747601, 26747602, 39317787, 47207321, 48414401, 48424022, 49854469, 50106737, 50106738, 50106739, 53777996, 56422415, 74505398, 87220220, 91011388, 92124194, 92125164, 92304336, 92307601, 99301263, 103770989, 103914089, 113862915, 121264371, 121361486, 121362835, 124637085, 124800889, 124800890, 134338608, 134340402, 134972293, 135697893, 144075206, 144207712, 144233404, 152090224, 162227138, 163564844, 172829020, 175266358
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| SuperDrug ATC ID |
D04AA02; R06AC01
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [2], [3], [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54. | ||||
| REF 2 | Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7. | ||||
| REF 3 | Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat. Inflamm Res. 2009 Jun 21. | ||||
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