| Drug General Information |
| Drug ID |
D0H8XV
|
| Former ID |
DNC009877
|
| Drug Name |
R-dimethindene
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H24N2
|
| Canonical SMILES |
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
|
| InChI |
1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m0/s1
|
| InChIKey |
MVMQESMQSYOVGV-HNNXBMFYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Potassium voltage-gated channel subfamily H member 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
| Histamine H1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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PI3K-Akt signaling pathway
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Cholinergic synapse
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
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PathWhiz Pathway
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Muscle/Heart Contraction
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Reactome
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Voltage gated Potassium channelsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
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G alpha (q) signalling events
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WikiPathways
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SIDS Susceptibility Pathways
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Hematopoietic Stem Cell Differentiation
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Potassium ChannelsWP58:Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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IL-4 Signaling Pathway
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GPCR downstream signaling
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| References |
| REF 1 | J Med Chem. 2009 Sep 10;52(17):5307-10.Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. |
|---|
