Drug General Information
Drug ID
D06FES
Former ID
DAP000177
Drug Name
Doxepin
Synonyms
Cidoxepin; Cidoxepina; Cidoxepinum; Doxepina; Doxepine; Doxepinum; Quitaxon; Sinequan; Triadapin; Zonalon; Cidoxepin [INN]; Doxepin Hydrochloride; Doxepin [USAN]; MF 10; MOLI001594; Adapine (TN); Aponal (TN); Cis-doxepin; Deptran (TN); Doxepin (INN); Doxepin, Hydrochloride; Doxepina [INN-Spanish]; Doxepinum [INN-Latin]; Sinequan (TN); Sinquan (TN); Xepin (TN); Zonalon (TN); Doxepin (Z)-isomer; N,N-Dimethyldibenz(b,e)oxepin-delta(11(6H),gamma)-propylamine; Cis-N-(3-(6H-Dibenz(b,e)oxepin-11-yliden)propyl)-N,N-dimethylamin; (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; (3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; (3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-di(methyl)propan-1-amine; (3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; (3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; (Z)-Doxepin; 11-(3-(Dimethylamino)propylidene)-6H-dibenz(b,e)oxepine; 11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenz(b,e)oxipin; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin; 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; 3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine; 3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536306], [538737]
Therapeutic Class
Antidepressants
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C19H21NO
InChI
InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+
InChIKey
ODQWQRRAPPTVAG-GZTJUZNOSA-N
CAS Number
CAS 1668-19-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:4710
SuperDrug ATC ID
N06AA12
SuperDrug CAS ID
cas=001668195
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [536469]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 538737(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1225).
Ref 536469Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305.

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