Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0FQ4M
|
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| Former ID |
DIB014549
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| Drug Name |
Selenotifen
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| Synonyms |
BN-52256
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Ipsen
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c12C(=C3CCN(CC3)C)c3c(CC(=O)c1[se]cc2)cccc3
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| CAS Number |
CAS 135472-91-2
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001341) | ||||
| REF 2 | Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. Pharmacol Res. 1992 Feb-Mar;25(2):173-80. | ||||
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