Drug Information

Drug General Information
Drug ID
D04USC
Former ID
DAP001379
Drug Name
Ergotidine
Synonyms
Eramin; Ergamine; Histamine; Histaminum; Istamina; Theramine; Free histamine; Histamine Base; Histamine [USAN]; Istamina [Italian]; H7125_SIGMA; [3H]histamine; ALBB-005968; Beta-Aminoethylglyoxaline; Beta-Aminoethylimidazole; Beta-aminothethylglyoxaline; Histamine (DCF); Histamine, Free Base; Histaminum (TN); L-histamine; ZERO/004089; Imidazole-4-ethylamine; Beta-Imidazolyl-4-ethylamine; F411C768-A159-4FC0-A195-291A08BB03AA; 1H-Imidazole-4-ethanamine; 1H-Imidazole-5-ethanamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-imidazol-4-yl)ethan-1-amine; 2-(1H-imidazol-5-yl)ethanamine; 2-(3H-Imidazol-4-yl)-ethylamine; 2-(4-Imidazolyl)ethylamine; 2-Imidazol-4-ylethylamine; 2-[4-Imidazolyl]ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 4-Imidazoleethylamine; 5-Imidazoleethylamine
Drug Type
Small molecular drug
Indication Respiratory allergies; Cancer [ICD9: 460-519, 140-229; ICD10:J00-J99, C00-C96] Approved [535111], [538761], [551871]
Therapeutic Class
Antiallergic Agents
Structure
Download
2D MOL

3D MOL
Formula
C5H9N3
InChI
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey
NTYJJOPFIAHURM-UHFFFAOYSA-N
CAS Number
CAS 75614-87-8
PubChem Compound ID
774
PubChem Substance ID
3678, 91789, 609692, 822767, 824161, 853773, 3156918, 3221723, 3727072, 5065169, 5186157, 6436474, 7735853, 7888228, 7979989, 8139979, 8143824, 8150782, 10524836, 11108702, 11111275, 11120367, 11120855, 11121343, 11121734, 11122214, 11335483, 11360722, 11362871, 11363739, 11365433, 11366301, 11367995, 11368863, 11370953, 11370954, 11371444, 11373596, 11374718, 11376157, 11377025, 11461694, 11484465, 11488481, 11490268, 11492775, 11494659, 11537616, 15146444, 16080673
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [535111]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
Ref 538761(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1247).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

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