Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I5UU
|
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| Former ID |
DNC001035
|
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| Drug Name |
Norastemizole
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Discontinued in Preregistration | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H21FN4
|
||||
| Canonical SMILES |
C1CNCCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F
|
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| InChI |
1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
|
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| InChIKey |
SFOVDSLXFUGAIV-UHFFFAOYSA-N
|
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| CAS Number |
CAS 75970-64-8
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10240800, 11538012, 12014873, 14777201, 29303850, 47207679, 50066133, 57340487, 76897838, 96099860, 103088876, 103157266, 103247597, 104011330, 104418924, 109614770, 117509932, 129228977, 134339274, 134340293, 135079335, 137237678, 140278629, 164231482, 179151099, 198989887, 224821565, 226408231, 241135945
|
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Modulator | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007228) | ||||
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