Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09TEI
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| Former ID |
DIB008761
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| Drug Name |
ReN-1869
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| Synonyms |
Neurin project, ReNeuron; ReN-0189; NNC-05-1869; NNC-47-0189
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 2 | [1] | ||
| Company |
Novo Nordisk Pharmaceuticals Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C1(=CCCN2C[C@H](C(=O)O)CCC2)c2c(CCc3c1cccc3)cccc2
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| CAS Number |
CAS 170149-99-2
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014046) | ||||
| REF 2 | ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57. | ||||
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