Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08NXC
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| Former ID |
DNC014184
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| Drug Name |
1-[(Furan-2(5H)-one)-4-methyl]-desloratadine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C24H23ClN2O2
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| Canonical SMILES |
C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)CC4=CC(=O)OC4)C5=C1C=C<br />C=N5
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| InChI |
1S/C24H23ClN2O2/c25-20-5-6-21-19(13-20)4-3-18-2-1-9-26-24(18)23(21)17-7-10-27(11-8-17)14-16-12-22(28)29-15-16/h1-2,5-6,9,12-13H,3-4,7-8,10-11,14-15H2
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| InChIKey |
CHEQBNZJRBHHQT-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. Epub 2010 Jan 4.Stereoselective synthesis of desloratadine derivatives as antagonist of histamine. | ||||
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