Drug Information
Drug General Information | |||||
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Drug ID |
D0M8PW
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Former ID |
DAP001397
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Drug Name |
Levocetirizine dihydrochloride
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Synonyms |
Xyzal; Xyzall; Levocetirizine HCl; Levocetirizine dihydrochloride [USAN]; Levocetirizine hydrochloride; Levocetirizine 2HCl; KS-1177; Levocetirizine hydrochloride (JAN); Vozet (TN); Xozal (TN); Xusal (TN); Xuzal (TN); Xyzal (TN); Xyzall (TN); Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride; (2-(4-((R)-(4-Chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antiallergic Agents
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Company |
GlaxoSmithKline
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Structure |
Download2D MOL |
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Formula |
C21H25ClN2O3
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InChI |
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
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InChIKey |
ZKLPARSLTMPFCP-OAQYLSRUSA-N
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CAS Number |
CAS 130018-77-8
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PubChem Compound ID | |||||
PubChem Substance ID |
11545046, 14927596, 26719822, 32248928, 46386593, 47583669, 47805464, 48179644, 48253864, 49681558, 49861381, 50276924, 51091738, 57409063, 92308500, 92714143, 93166949, 93302554, 103771174, 110525158, 124659008, 124799922, 126629651, 126655634, 126670860, 131297234, 134338605, 135107372, 135650416, 136211813, 136351130, 137001886, 139283254, 143494987, 152235888, 162258150, 163423572, 164837925, 172080394, 172859038, 175267409, 175270481, 179149784, 184548289, 184654357, 196111560, 211534825, 223258882, 223582092, 223657396
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SuperDrug ATC ID |
R06AE09
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SuperDrug CAS ID |
cas=130018778
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Target and Pathway | |||||
Target(s) | Histamine H1 receptor | Target Info | Antagonist | [535339], [536700], [537072] | |
PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
References | |||||
Ref 538587 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022064. | ||||
Ref 538725 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1214). | ||||
Ref 535339 | Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. Pol J Pharmacol. 2001 Jan-Feb;53(1):93-6. | ||||
Ref 536700 | Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29. | ||||
Ref 537072 | Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8. |
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