Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08TLI
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| Former ID |
DIB016191
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| Drug Name |
E-4716
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| Synonyms |
Mapinastine
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| Indication | Respiratory disease [ICD10:J00-J99] | Phase 2 | [1] | ||
| Company |
Laboratorios Dr Esteve SA
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(nc2c(n1CCOCC)cccc2)CN1CCN(CC1)CCCCn1nccc1.C(=O)(/C=C<br />\C(=O)O)O.C(=O)(/C=C\C(=O)O)O
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| CAS Number |
CAS 179188-69-3
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53. | ||||
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