Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0XY3G
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| Former ID |
DIB018516
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| Drug Name |
2-(2-thiazolyl)ethanamine
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| Synonyms |
2-thiazoleethanamine; 2-thiazolylethylamine; 2-(2-aminoethyl)thiazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C5H8N2S
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| InChI |
InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2
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| InChIKey |
TWZOYAWHWDRMEZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10222545, 15066180, 44418910, 47510099, 47731286, 49846680, 50064558, 57334365, 57565808, 77903683, 85208916, 91097527, 92729673, 96024148, 103122444, 103193827, 104394464, 104812445, 117522156, 117531396, 117677572, 118078219, 121279972, 125292686, 125327175, 125410594, 129326154, 129652146, 131383609, 135042351, 135606373, 135649682, 142507455, 143424665, 143896361, 162055648, 162209071, 162474504, 163585536, 163796673, 164772042, 166984611, 170520697, 186015956, 202822041, 223393723, 223446362, 223569500, 224780340, 226957200
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1193). | ||||
| REF 2 | Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6. | ||||
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