Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06UDO
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| Former ID |
DAP001073
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| Drug Name |
Phenindamine
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| Synonyms |
Fenindamina; Phenindaminum; Phenindiamine; Thephorin; NU 1504; Fenindamina [INN-Spanish]; Nolahist (TN); Phenindamine (INN); Phenindamine [INN:BAN]; Phenindaminum [INN-Latin]; Thephorin (TN); 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-lH-indeno(2,1-c)pyridine; 2,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine; 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine; 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
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| Drug Type |
Small molecular drug
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| Indication | Common cold; Allergies [ICD9: 460, 995.3; ICD10:J00, T78.4] | Approved | [1] | ||
| Therapeutic Class |
Antihistamines
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| Company |
Amarin Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C19H19N
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| Canonical SMILES |
CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4
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| InChI |
1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3
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| InChIKey |
ISFHAYSTHMVOJR-UHFFFAOYSA-N
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| CAS Number |
CAS 82-88-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9992, 5828595, 8158255, 10536692, 14798985, 29279614, 46508187, 47589508, 47662790, 48416411, 49982991, 57326826, 74922133, 85209749, 92729666, 96025040, 103191539, 103987990, 104325684, 125823857, 126680611, 128212933, 134338330, 135021495, 137263871, 142971053, 160964855, 179226015, 217848790, 223440638, 223682358, 226416560, 241151386, 250104383
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| SuperDrug ATC ID |
R06AX04
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| SuperDrug CAS ID |
cas=000082882
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| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Drug information of Phenindamine, 2008. eduDrugs. | ||||
| REF 2 | The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem. 1995 Aug 18;38(17):3351-60. | ||||
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