Target Information

Target General Infomation
Target ID
T94033
Former ID
TTDS00202
Target Name
Coagulation factor IIa
Gene Name
F2
Synonyms
Coagulation factor II; Prothrombin; F2
Target Type
Successful
Disease Atopic dermatitis [ICD9: 691.8, 692.9; ICD10: L00-L99]
Angina pectoris [ICD9: 413; ICD10: I20]
Blood forming organ disorders [ICD10: D75.9]
Bleeding [ICD9: 444, 453; ICD10: I74, I80-I82]
Blood coagulation disorders [ICD10: D65-D68]
Coagulation [ICD10: I80-I82]
Cardiovascular disorder [ICD10: I00-I99]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Heart arrhythmia [ICD10: I47-I49]
Myocardial infarction [ICD9: 410; ICD10: I21, I22]
Nonvalvular atrial fibrillation; Thrombosis [ICD9: 427.31, 437.6, 453, 671.5, 671.9; ICD10: I48, I80-I82]
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89]
Stroke in atrial fibrillation [ICD9: 427.31, 434.91; ICD10: I48, I61-I63]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10: D69.6, P61.0]
Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10: I80-I82]
Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10: I80-I82]
Venous thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10: I80-I82]
Unspecified [ICD code not available]
Function
Thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
BioChemical Class
Peptidase
Target Validation
T94033
UniProt ID
P00734
EC Number
EC 3.4.21.5
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Drugs and Mode of Action
Drug(s) Anisindione Drug Info Approved Coagulation [538440], [541995]
Bivalirudin Drug Info Approved Thrombocytopenia [536361], [541605]
Dabigatran Drug Info Approved Stroke in atrial fibrillation [531351], [541518]
Lepirudin Drug Info Approved Thrombocytopenia [536361], [541604]
Hirudin Drug Info Phase 4 Discovery agent [524467]
MELAGATRAN Drug Info Phase 3 Discovery agent [521709], [541520]
SR-123781A Drug Info Phase 2/3 Venous thrombosis [521845]
EFEGATRAN SULFATE HYDRATE Drug Info Phase 2 Myocardial infarction [527625]
EP-217609 Drug Info Phase 2 Thrombosis [549210]
LB-30870 Drug Info Phase 2 Myocardial infarction [551846]
NU-172 Drug Info Phase 2 Thrombosis [522521]
Odiparcil Drug Info Phase 2 Cardiovascular disorder [521747]
Pegmusirudin Drug Info Phase 2 Angina pectoris [521580]
Recombinant RGD-hirudin Drug Info Phase 2 Thrombosis [530928]
AZD-8165 Drug Info Phase 1 Thrombosis [523086], [542697]
DP-4088 Drug Info Phase 1 Blood coagulation disorders [548782]
EP-42675 Drug Info Phase 1 Thrombosis [548235]
RWJ-671818 Drug Info Phase 1 Thrombosis [530660]
Solulin Drug Info Phase 1 Thrombosis [531504]
SSR-128428 Drug Info Phase 1 Thromboembolism [547951]
H376/95 Drug Info Withdrawn from market Discovery agent [521708]
Ximelagatran Drug Info Withdrawn from market Coagulation [536361], [541519]
AZD0837 Drug Info Discontinued in Phase 2 Nonvalvular atrial fibrillation; Thrombosis [542662], [547675]
Dermolastin Drug Info Discontinued in Phase 2 Atopic dermatitis [547642]
INOGATRAN Drug Info Discontinued in Phase 2 Myocardial infarction [545842]
Napsagatran Drug Info Discontinued in Phase 2 Myocardial infarction [545647]
SSR-182289 Drug Info Discontinued in Phase 2 Myocardial infarction [547360]
Vasoflux Drug Info Discontinued in Phase 2 Myocardial infarction [546404]
ARC-183 Drug Info Discontinued in Phase 1 Blood forming organ disorders [547835]
BCX-1470 Drug Info Discontinued in Phase 1 Bleeding [546724]
CJC-1004 Drug Info Discontinued in Phase 1 Thrombosis [547263]
CVS-1123 Drug Info Discontinued in Phase 1 Myocardial infarction [545765]
GW-473178 Drug Info Discontinued in Phase 1 Heart arrhythmia [547305]
Licostinel Drug Info Discontinued in Phase 1 Neurological disease [545531]
MPC-0920 Drug Info Discontinued in Phase 1 Thrombosis [548226]
S-18326 Drug Info Discontinued in Phase 1 Myocardial infarction [545791]
UK-156406 Drug Info Discontinued in Phase 1 Myocardial infarction [546743]
BCH-2763 Drug Info Terminated Thrombosis [546230]
BMS-189664 Drug Info Terminated Myocardial infarction [546805]
CVS-995 Drug Info Terminated Myocardial infarction [545766]
DuP 714 Drug Info Terminated Thromboembolism [545010]
Efegatran Drug Info Terminated Discovery agent [545040]
GS-522 Drug Info Terminated Thromboembolism [545438]
Hementin Drug Info Terminated Thromboembolism [545852]
L-373890 Drug Info Terminated Thrombosis [546669]
L-374,087 Drug Info Terminated Thrombosis [546605]
LB30057 Drug Info Terminated Discovery agent [546602]
Org-34092 Drug Info Terminated Thromboembolism [546864]
PPACK Drug Info Terminated Discovery agent [545056]
SR-80027A Drug Info Terminated Thromboembolism [545878]
Inhibitor (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone Drug Info [529037]
(3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone Drug Info [529037]
(3-nitro-1H-pyrazol-1-yl)(phenyl)methanone Drug Info [529037]
(4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone Drug Info [529037]
(4-nitro-1H-pyrazol-1-yl)(o-tolyl)methanone Drug Info [529037]
(4-nitro-1H-pyrazol-1-yl)(phenyl)methanone Drug Info [529037]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose Drug Info [534762]
1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE Drug Info [551374]
1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide Drug Info [529037]
2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine Drug Info [526118]
2-NAPHTHALENESULFONIC ACID Drug Info [551374]
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine Drug Info [528292]
3-(4-HYDROXY-PHENYL)PYRUVIC ACID Drug Info [551374]
3-chlorophenyl 2-oxo-2H-chromene-3-carboxylate Drug Info [527883]
4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL Drug Info [551374]
4-(3,4-Diethoxy-benzylamino)-benzamidine Drug Info [527397]
4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine Drug Info [527397]
4-Iodobenzo[B]Thiophene-2-Carboxamidine Drug Info [551374]
4-TERT-BUTYLBENZENESULFONIC ACID Drug Info [551374]
4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE Drug Info [551374]
5-desgalloylstachyurin Drug Info [534762]
6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE Drug Info [551374]
AC-(D)PHE-PRO-BOROHOMOLYS-OH Drug Info [551374]
AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH Drug Info [551374]
AC-(D)PHE-PRO-BOROLYS-OH Drug Info [551374]
AZD-8165 Drug Info [543606]
AZD0837 Drug Info [550288]
Bbs-Arg-(D-Pip)-Gly-(EQKLISEEDL)-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-(SPH(pY)EKVS)-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-(SPHYEKVS)-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)1-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)11-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)13-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)3-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)5-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)7-Gly-Hir Drug Info [527780]
Bbs-Arg-(D-Pip)-Gly-S-(GS)9-Gly-Hir Drug Info [527780]
BCH-2763 Drug Info [538083]
BCX-1470 Drug Info [544115]
BENZOTHIAZOLE Drug Info [551374]
Beta-(2-Naphthyl)-Alanine Drug Info [551374]
Beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide Drug Info [551374]
Bivalirudin Drug Info [535224]
Bivalirudine Drug Info [535345]
BMS-189664 Drug Info [551871]
BMS-344577 Drug Info [530503]
BMS-740808 Drug Info [529194]
CASUARIIN Drug Info [534762]
CHLORODYSINOSIN A Drug Info [530312]
CJC-1004 Drug Info [526666]
COCHINCHINENENE B Drug Info [529057]
COCHINCHINENIN B Drug Info [529057]
CRA_8696 Drug Info [551374]
CVS-1123 Drug Info [534333]
CVS-995 Drug Info [534248]
Cyclotheonamide E Drug Info [526298]
Cyclotheonamide E4 Drug Info [526298]
Cyclotheonamide E5 Drug Info [526298]
D-leucyl-N-(3-chlorobenzyl)-L-prolinamide Drug Info [551374]
D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide Drug Info [551374]
D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide Drug Info [551374]
D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide Drug Info [551374]
D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide Drug Info [551374]
D-phenylalanyl-N-benzyl-L-prolinamide Drug Info [551374]
D-Pro-Phe-Arg chloromethyl ketone Drug Info [529454]
Dabigatran Drug Info [531351]
Dermolastin Drug Info [536190], [536840], [537435], [551533]
Desirudine Drug Info [535345]
DP-4088 Drug Info [543606]
DuP 714 Drug Info [535205]
DYSINOSIN A Drug Info [530312]
Efegatran Drug Info [535205]
EFEGATRAN SULFATE HYDRATE Drug Info [551871]
Enoxaprin Drug Info [537910]
Gamma-Carboxy-Glutamic Acid Drug Info [551393]
GR-133686 Drug Info [534803]
GS-522 Drug Info [534196]
GW-473178 Drug Info [547306]
H376/95 Drug Info [535224]
Haempatch Drug Info [543606]
Hementin Drug Info [533550]
Hemi-Babim Drug Info [551374]
Heparin-Cantithrombin III Drug Info [535514]
Hirudin Drug Info [535224], [535605], [538091]
Hirulog Drug Info [538091]
L-370,518 Drug Info [538091]
L-373890 Drug Info [534784]
L-374,087 Drug Info [535728]
L-375378 Drug Info [526487]
LB-30870 Drug Info [551871]
LB30057 Drug Info [535684]
LB30812 Drug Info [535774]
Lepirudin Drug Info [534921]
Lepirudine Drug Info [535345]
Licostinel Drug Info [535658]
Lysophosphotidylserine Drug Info [551393]
Macrocyclic tripeptide motif Drug Info [551309]
MELAGATRAN Drug Info [528017]
Melogatran Drug Info [535514]
Methyl L-phenylalaninate Drug Info [551374]
METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE Drug Info [551374]
MPC-0920 Drug Info [549865]
N4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE Drug Info [551374]
Napsagatran Drug Info [534111]
NU-172 Drug Info [544213], [551844]
Odiparcil Drug Info [528425]
Org-34092 Drug Info [543606]
OSCILLARIN Drug Info [530312]
PEDUNCULAGIN Drug Info [534762]
PPACK Drug Info [535205]
RAZAXABAN Drug Info [530655]
RWJ-50353 Drug Info [529193]
S-18326 Drug Info [551871]
S-2238 Drug Info [535151]
SC-79407 Drug Info [535728]
SR-80027A Drug Info [533808]
SSR-182289 Drug Info [551871]
Tellimagrandin II Drug Info [534762]
UK-156406 Drug Info [551871]
Vasoflux Drug Info [534833]
VE-04051645 Drug Info [543606]
Ximelagatran Drug Info [537615]
Modulator Anisindione Drug Info [535724]
bufrudin, Biopharm Drug Info
CVS-1578 Drug Info
EP-217609 Drug Info
EP-42675 Drug Info [532552]
INOGATRAN Drug Info
Pegmusirudin Drug Info [543606]
Recombinant RGD-hirudin Drug Info [528917]
RWJ-671818 Drug Info [530660]
Solulin Drug Info [531504]
SR-123781A Drug Info [535183]
SSR-128428 Drug Info
TB-101 Drug Info [543606]
TB-102 Drug Info [543606]
Tumor vascular thrombogen Drug Info [543606]
Cofactor Vitamin K Drug Info [537752]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Regulation of actin cytoskeleton
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Blood coagulation
Pathway Interaction Database Thrombin/protease-activated receptor (PAR) pathway
Angiopoietin receptor Tie2-mediated signaling
FOXA2 and FOXA3 transcription factor networks
PAR4-mediated thrombin signaling events
Syndecan-4-mediated signaling events
PAR1-mediated thrombin signaling events
PathWhiz Pathway Vitamin K Metabolism
Coagulation
Reactome Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways Complement and Coagulation Cascades
Regulation of Actin Cytoskeleton
IL1 and megakaryotyces in obesity
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Thrombin signalling through proteinase activated receptors (PARs)
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signaling
Formation of Fibrin Clot (Clotting Cascade)
Cell surface interactions at the vascular wall
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 521580ClinicalTrials.gov (NCT00074620) A Clinical Study to Assess the Safety of PEG-Hirudin (SPP200) Compared to Heparin in Patients Who Are on Haemodialysis. U.S. National Institutes of Health.
Ref 521708ClinicalTrials.gov (NCT00206063) Long Term Open Follow-up With H376/95 vs. Warfarin. U.S. National Institutes of Health.
Ref 521709ClinicalTrials.gov (NCT00206089) Melagatran/Ximelagatran Versus Enoxaparin for the Prevention of Venous Thromboembolic Events. U.S. National Institutes of Health.
Ref 521747ClinicalTrials.gov (NCT00240643) Use Of SB424323 With Aspirin In Non-Valvular Atrial Fibrillation In Patients At A Low Or Intermediate Risk For Stroke. U.S. National Institutes of Health.
Ref 521845ClinicalTrials.gov (NCT00338897) Dose Ranging Study in Elective Total Hip Replacement Surgery. U.S. National Institutes of Health.
Ref 522521ClinicalTrials.gov (NCT00808964) Study of NU172 as Anticoagulation in Patients Undergoing Off-pump CABG Surgery. U.S. National Institutes of Health.
Ref 523086ClinicalTrials.gov (NCT01150812) Oral AZD8165 After Single Oral Ascending Doses in Healthy Male Subjects. U.S. National Institutes of Health.
Ref 524467ClinicalTrials.gov (NCT01960569) Topical r-Hirudin ( Thrombexx ) Efficacy in Treatment of Haematomas. U.S. National Institutes of Health.
Ref 527625Efegatran. Institute for drug research/IVAX. IDrugs. 2001 Jun;4(6):691-4.
Ref 530660J Med Chem. 2010 Feb 25;53(4):1843-56.Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
Ref 530928The antithrombotic effect of a novel hirudin derivative after reconstruction of carotid artery in rabbits. Thromb Res. 2010 Oct;126(4):e339-43.
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 531504The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model. J Thromb Haemost. 2011 Jun;9(6):1174-82.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 538440FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010909.
Ref 541518(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6380).
Ref 541519(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6381).
Ref 541520(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6382).
Ref 541604(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6469).
Ref 541605(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6470).
Ref 541995(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6960).
Ref 542662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7682).
Ref 542697(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7727).
Ref 545010Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001867)
Ref 545040Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001951)
Ref 545056Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001987)
Ref 545438Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003259)
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Ref 545766Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004615)
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Ref 546404Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007938)
Ref 546602Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009139)
Ref 546605Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009151)
Ref 546669Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009558)
Ref 546724Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009938)
Ref 546743Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010067)
Ref 546805Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010403)
Ref 546864Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010730)
Ref 547263Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014574)
Ref 547305Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015039)
Ref 547360Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015478)
Ref 547642Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018071)
Ref 547675Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018351)
Ref 547835Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019755)
Ref 547951Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020651)
Ref 548226Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023381)
Ref 548235Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023539)
Ref 548782Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028740)
Ref 549210Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033781)
Ref 551846Frontiers in Anti-Infective Drug Discovery, Atta-ur-Rahman, ??. Iqbal Choudhary. Page(57).
Ref 526118J Med Chem. 2001 Aug 16;44(17):2753-71.Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
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