| Drug General Information |
| Drug ID |
D00QDR
|
| Former ID |
DNC008869
|
| Drug Name |
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
|
| Synonyms |
Pentagalloyl glucose; Penta-O-galloyl-beta-glucoside
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C41H32O26
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Coagulation factor Xa |
Target Info |
Inhibitor |
[1]
|
|---|
| Squalene monooxygenase |
Target Info |
Inhibitor |
[2]
|
| Xanthine dehydrogenase/oxidase |
Target Info |
Inhibitor |
[3]
|
| Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Purine nucleotides degradation
|
|
Urate biosynthesis/inosine 5'-phosphate degradation
|
|
Guanosine nucleotides degradation
|
|
Adenosine nucleotides degradation
|
|
Retinoate biosynthesis II
|
|
KEGG Pathway
|
Complement and coagulation cascadessce00100:Steroid biosynthesis
|
|
Sesquiterpenoid and triterpenoid biosynthesis
|
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Metabolic pathways
|
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Biosynthesis of secondary metabolites
|
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Biosynthesis of antibioticshsa00230:Purine metabolism
|
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Caffeine metabolism
|
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Drug metabolism - other enzymes
|
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Metabolic pathways
|
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Peroxisomehsa04080:Neuroactive ligand-receptor interaction
|
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Complement and coagulation cascades
|
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Regulation of actin cytoskeleton
|
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NetPath Pathway
|
TCR Signaling Pathway
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PANTHER Pathway
|
Blood coagulationP02723:Adenine and hypoxanthine salvage pathway
|
|
Purine metabolismP00011:Blood coagulation
|
|
Pathway Interaction Database
|
Beta2 integrin cell surface interactionsthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
|
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Angiopoietin receptor Tie2-mediated signaling
|
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FOXA2 and FOXA3 transcription factor networks
|
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PAR4-mediated thrombin signaling events
|
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
|
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PathWhiz Pathway
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CoagulationPW000050:Steroid BiosynthesisPW000015:Caffeine Metabolism
|
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Purine MetabolismPW000047:Vitamin K Metabolism
|
|
Coagulation
|
|
Reactome
|
Extrinsic Pathway of Fibrin Clot Formation
|
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Intrinsic Pathway of Fibrin Clot Formation
|
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Common Pathway of Fibrin Clot Formation
|
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Gamma-carboxylation of protein precursors
|
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
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Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-191273:Cholesterol biosynthesis
|
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Activation of gene expression by SREBF (SREBP)R-HSA-74259:Purine catabolismR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
|
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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G alpha (q) signalling events
|
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Thrombin signalling through proteinase activated receptors (PARs)
|
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WikiPathways
|
Complement and Coagulation Cascades
|
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Human Complement System
|
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
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Blood Clotting Cascade
|
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Formation of Fibrin Clot (Clotting Cascade)WP408:Oxidative Stress
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Effects of Nitric Oxide
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Metabolism of nucleotides
|
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Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
|
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
|
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
|
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Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | J Nat Prod. 1998 Nov;61(11):1356-60.Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. |
|---|
| REF 2 | J Nat Prod. 2001 Aug;64(8):1010-4.Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. |
|---|
| REF 3 | Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug, "Molle-i" (Schinus terebinthifolius). J Nat Prod. 1989 Jan-Feb;52(1):210-1. |
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