| Drug General Information |
| Drug ID |
D07QPA
|
| Former ID |
DNC001500
|
| Drug Name |
Vitamin K
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C31H46O2
|
| Canonical SMILES |
CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)<br />C
|
| InChI |
1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+
|
| InChIKey |
MBWXNTAXLNYFJB-LKUDQCMESA-N
|
| CAS Number |
CAS 12001-79-5
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5148, 570425, 646623, 7847216, 8616290, 10536482, 10536899, 14784162, 29215362, 39289590, 48498323, 49995626, 53787905, 56365821, 57260129, 57260130, 57357755, 57390757, 80851796, 83584131, 87574801, 88828962, 103120368, 113853339, 117586800, 124576737, 124800047, 124897843, 126524869, 134338510, 134972505, 135078748, 135234658, 135263933, 137142313, 137240036, 139059465, 162090649, 179093928, 179226024, 184545593, 184551948, 241203223, 242084697, 250130715, 251871784
|
| ChEBI ID |
ChEBI:28384
|
| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Cofactor |
[1]
|
|---|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Complement and coagulation cascades
|
|
Regulation of actin cytoskeleton
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulation
|
|
Pathway Interaction Database
|
Thrombin/protease-activated receptor (PAR) pathway
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
PAR4-mediated thrombin signaling events
|
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Syndecan-4-mediated signaling events
|
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PAR1-mediated thrombin signaling events
|
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PathWhiz Pathway
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Vitamin K Metabolism
|
|
Coagulation
|
|
Reactome
|
Intrinsic Pathway of Fibrin Clot Formation
|
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Common Pathway of Fibrin Clot Formation
|
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
|
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Complement and Coagulation Cascades
|
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Regulation of Actin Cytoskeleton
|
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IL1 and megakaryotyces in obesity
|
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
|
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
|
| References |
| REF 1 | Plasma levels of protein C and vitamin K-dependent coagulation factors in patients on long-term oral anticoagulant therapy. Tohoku J Exp Med. 1986 Aug;149(4):351-7. |
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