| Drug General Information |
| Drug ID |
D0G0XN
|
| Former ID |
DIB015566
|
| Drug Name |
UK-156406
|
| Synonyms |
1-[3-(3-Amidinophenyl)-2(S)-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylsulfonamido)propionyl]-4-methyl-1,2,3,6-tetrahydropyridine-2(R)-carboxylic acid; 1-[3-Amidino-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylsulfonyl)-L-phenylalanyl]-4-methyl-1,2,3,6-tetrahydropyridine-2(R)-carboxylic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Myocardial infarction [ICD9: 410; ICD10:I21, I22]
|
Discontinued in Phase 1 |
[1]
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C27H33N5O5S
|
| Canonical SMILES |
CN1CCc2ccc(cc2C1)S(=O)(=O)N[C@@H](Cc3ccc(cc3)C(=N)N)C(=<br />O)N4CC=C(C)C[C@@H]4C(=O)O
|
| InChI |
1S/C27H33N5O5S/c1-17-9-12-32(24(13-17)27(34)35)26(33)23(14-18-3-5-20(6-4-18)25(28)29)30-38(36,37)22-8-7-19-10-11-31(2)16-21(19)15-22/h3-9,15,23-24,30H,10-14,16H2,1-2H3,(H3,28,29)(H,34,35)/t23-,24+/m0/s1
|
| InChIKey |
ZDHBBBQAVLNJBL-BJKOFHAPSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[2]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Regulation of actin cytoskeleton
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulation
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Pathway Interaction Database
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Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
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Vitamin K Metabolism
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Coagulation
|
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Reactome
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Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010067) |
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| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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