Drug General Information |
Drug ID |
D0U5YK
|
Former ID |
DNC000869
|
Drug Name |
Lepirudine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C8H10NO6P
|
Canonical SMILES |
CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
|
InChI |
1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
|
InChIKey |
NGVDGCNFYWLIFO-UHFFFAOYSA-N
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CAS Number |
CAS 124051-94-1
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PubChem Compound ID |
|
PubChem Substance ID |
3320, 121085, 599931, 815692, 820455, 820457, 820459, 823621, 827878, 833938, 841448, 3139703, 7437583, 7889933, 8020819, 8026880, 8027925, 8143776, 8150946, 14847611, 17486472, 24277549, 24424162, 24424511, 24439404, 24715040, 24778767, 26512264, 26704334, 26714858, 26750672, 29218058, 46506428, 49689875, 49743070, 49835405, 50035336, 53790888, 56261100, 56261107, 56394786, 56437588, 57304362, 57320698, 74479622, 81064697, 81087301, 84975011, 84975013, 84982058
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Target and Pathway |
Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Regulation of actin cytoskeleton
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulation
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Pathway Interaction Database
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Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
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Vitamin K Metabolism
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Coagulation
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Reactome
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Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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References |
REF 1 | New antithrombotic drugs (excluding plasminogen activators. Arch Mal Coeur Vaiss. 2001 Nov;94(11 Suppl):1225-32. |