| Drug General Information |
| Drug ID |
D0N0PI
|
| Former ID |
DNC002480
|
| Drug Name |
2-NAPHTHALENESULFONIC ACID
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H8O3S
|
| Canonical SMILES |
C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O
|
| InChI |
1S/C10H8O3S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,11,12,13)
|
| InChIKey |
KVBGVZZKJNLNJU-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3157093, 5359507, 7889294, 8155931, 14773250, 24855002, 26697193, 29227114, 32023989, 38385260, 47205510, 49995876, 56370065, 57325002, 79262067, 85228135, 87244290, 87563371, 87573772, 87623872, 92721048, 99444725, 103121130, 104250779, 104317804, 117633431, 118309719, 125339170, 126627751, 126636924, 126669171, 127409973, 127456772, 127951681, 128012010, 128040558, 128272395, 128438809, 128970768, 129326182, 129603427, 129613731, 129718177, 129787162, 134974885, 137009445, 142338445, 143435357, 143489565, 143719547
|
| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|---|
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
|
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Regulation of actin cytoskeleton
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulation
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Pathway Interaction Database
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Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
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Vitamin K Metabolism
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Coagulation
|
|
Reactome
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Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
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