| Drug General Information |
| Drug ID |
D0K7YL
|
| Former ID |
DNC002458
|
| Drug Name |
CRA_8696
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| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H18N3O+
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=C(C(=CC=C2)C3C=C4C=C(C=CC4=[NH+]3)C(=[N<br />H2+])N)[O-]
|
| InChI |
1S/C21H17N3O/c22-21(23)14-9-10-18-15(11-14)12-19(24-18)17-8-4-7-16(20(17)25)13-5-2-1-3-6-13/h1-12,19,25H,(H3,22,23)/p+1
|
| InChIKey |
WMTXEHSIBCBYRJ-UHFFFAOYSA-O
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| PubChem Compound ID |
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| PubChem Substance ID |
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| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|---|
| Urokinase-type plasminogen activator |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Regulation of actin cytoskeletonhsa04064:NF-kappa B signaling pathway
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Transcriptional misregulation in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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NetPath Pathway
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TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
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EGFR1 Signaling Pathway
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PANTHER Pathway
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Blood coagulationP00011:Blood coagulation
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Plasminogen activating cascade
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CCKR signaling map ST
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Pathway Interaction Database
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Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling eventsintegrin1_pathway:Beta1 integrin cell surface interactions
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E2F transcription factor network
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Beta3 integrin cell surface interactions
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Osteopontin-mediated events
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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amb2 Integrin signaling
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ATF-2 transcription factor network
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AP-1 transcription factor network
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Beta2 integrin cell surface interactions
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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Beta5 beta6 beta7 and beta8 integrin cell surface interactions
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FGF signaling pathway
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PathWhiz Pathway
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Vitamin K Metabolism
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Coagulation
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Reactome
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Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)R-HSA-75205:Dissolution of Fibrin Clot
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WikiPathways
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Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient NetworkWP710:DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
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Endochondral Ossification
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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Dissolution of Fibrin Clot
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Osteopontin Signaling
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
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