| Drug General Information |
| Drug ID |
D0U4HG
|
| Former ID |
DNC008076
|
| Drug Name |
COCHINCHINENIN B
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C33H34O7
|
| Canonical SMILES |
COC1=CC(=C(C=C1CCC(=O)C2=CC=C(C=C2)O)C(CCC3=C(C=C(C=C3)<br />O)OC)C4=CC=C(C=C4)O)OC
|
| InChI |
1S/C33H34O7/c1-38-31-19-27(36)15-8-23(31)9-16-28(21-4-11-25(34)12-5-21)29-18-24(32(39-2)20-33(29)40-3)10-17-30(37)22-6-13-26(35)14-7-22/h4-8,11-15,18-20,28,34-36H,9-10,16-17H2,1-3H3
|
| InChIKey |
QFWXEYRQNKRQDH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Complement and coagulation cascades
|
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Regulation of actin cytoskeleton
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
Blood coagulation
|
|
Pathway Interaction Database
|
Thrombin/protease-activated receptor (PAR) pathway
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|
Angiopoietin receptor Tie2-mediated signaling
|
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FOXA2 and FOXA3 transcription factor networks
|
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PAR4-mediated thrombin signaling events
|
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
|
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PathWhiz Pathway
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Vitamin K Metabolism
|
|
Coagulation
|
|
Reactome
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Intrinsic Pathway of Fibrin Clot Formation
|
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Common Pathway of Fibrin Clot Formation
|
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
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Cell surface interactions at the vascular wall
|
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Peptide ligand-binding receptors
|
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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G alpha (q) signalling events
|
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Thrombin signalling through proteinase activated receptors (PARs)
|
|
WikiPathways
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Complement and Coagulation Cascades
|
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Regulation of Actin Cytoskeleton
|
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IL1 and megakaryotyces in obesity
|
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
|
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
|
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Folate Metabolism
|
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Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | J Nat Prod. 2007 Oct;70(10):1570-7. Epub 2007 Sep 21.Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. |
|---|
