| Drug General Information |
| Drug ID |
D04CQG
|
| Former ID |
DNC000727
|
| Drug Name |
Heparin-Cantithrombin III
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C26H29Cl4N5O2
|
| Canonical SMILES |
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C<br />(C=CC=C4Cl)Cl.Cl.Cl
|
| InChI |
1S/C26H27Cl2N5O2.2ClH/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H
|
| InChIKey |
NADLBPWBFGTESN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14886877, 24696124, 45988041, 75322181, 134340082, 136946403, 144116350, 163122884, 204362264, 240065380, 241376631, 249617121, 251961701, 252157529
|
| Target and Pathway |
| Target(s) |
Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Complement and coagulation cascades
|
|
Regulation of actin cytoskeleton
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Blood coagulation
|
|
Pathway Interaction Database
|
Thrombin/protease-activated receptor (PAR) pathway
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
FOXA2 and FOXA3 transcription factor networks
|
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PAR4-mediated thrombin signaling events
|
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
|
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PathWhiz Pathway
|
Vitamin K Metabolism
|
|
Coagulation
|
|
Reactome
|
Intrinsic Pathway of Fibrin Clot Formation
|
|
Common Pathway of Fibrin Clot Formation
|
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Gamma-carboxylation of protein precursors
|
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
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Cell surface interactions at the vascular wall
|
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Peptide ligand-binding receptors
|
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
|
G alpha (q) signalling events
|
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Thrombin signalling through proteinase activated receptors (PARs)
|
|
WikiPathways
|
Complement and Coagulation Cascades
|
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Regulation of Actin Cytoskeleton
|
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IL1 and megakaryotyces in obesity
|
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
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Blood Clotting Cascade
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Thrombin signalling through proteinase activated receptors (PARs)
|
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Platelet Aggregation (Plug Formation)
|
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GPCR ligand binding
|
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
|
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Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Thrombin inhibitors in acute coronary artery disease. Eur Heart J. 2002 Aug;23(15):1142-4. |
|---|
