Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15739 Target Info
Target Name Cellular tumor antigen p53 (TP53)
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Target Type Clinical trial Target
Gene Name TP53
UniProt ID
P53_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-fractionation [1]
3 Reconstituted Complex [1]
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
Interacting Protein Name General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) Interacting Protein Interacting Protein Info
UniProt ID
ERCC2_HUMAN 
Synonyms COFS2; EM9; TFIIH; TTD; XPD
Evidence Score (E-score) 2 Experimental Evidences +
1 Far Western [4]
2 Reconstituted Complex [5]
Interacting Protein Name General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Interacting Protein Interacting Protein Info
UniProt ID
ERCC3_HUMAN 
Synonyms BTF2; GTF2H; RAD25; TFIIH; XPB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Acyltransferases [+] 15 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Luminescence [6]
2 Affinity Capture-Western [6]
3 Biochemical Activity [7]
4 Co-crystal Structure [8]
5 Co-fractionation [9]
6 Co-localization [10]
7 Protein-peptide [11]
8 Reconstituted Complex [12]
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [14]
3 Reconstituted Complex [15]
4 Yeast two hybrid [16]
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Biochemical Activity [18]
3 Co-crystal Structure [17]
4 Reconstituted Complex [19]
Interacting Target Name E3 ubiquitin-protein ligase COP1 (RFWD2) Literature-reported Target Interacting Protein Info
UniProt ID
COP1_HUMAN 
Synonyms RNF200; RING-type E3 ubiquitin transferase RFWD2; RING finger protein 200; RING finger and WD repeat domain protein 2; hCOP1; E3 ubiquitinprotein ligase RFWD2; COP1; Constitutive photomorphogenesis protein 1 homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [20]
3 Reconstituted Complex [20]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [22]
Interacting Protein Name E3 SUMO-protein ligase PIAS1 (PIAS1) Interacting Protein Interacting Protein Info
UniProt ID
PIAS1_HUMAN 
Synonyms DDXBP1; GBP; GU/RH.II; ZMIZ3
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [23]
2 Reconstituted Complex [24]
3 Yeast two hybrid [25]
Interacting Protein Name E3 SUMO-protein ligase PIAS2 (PIAS2) Interacting Protein Interacting Protein Info
UniProt ID
PIAS2_HUMAN 
Synonyms ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX.ALPHA; PIASX.BETA; SIZ2; ZMIZ4
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [23]
2 Reconstituted Complex [26]
3 Yeast two hybrid [27]
Interacting Protein Name SUMO-conjugating enzyme UBC9 (UBE2I) Interacting Protein Interacting Protein Info
UniProt ID
UBC9_HUMAN 
Synonyms C358B7.1; P18; UBC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Reconstituted Complex [29]
3 Yeast two hybrid [25]
Interacting Protein Name E3 ubiquitin-protein ligase UBR5 (UBR5) Interacting Protein Interacting Protein Info
UniProt ID
UBR5_HUMAN 
Synonyms DD5; EDD; EDD1; HYD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [30]
3 Reconstituted Complex [30]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [32]
Interacting Protein Name Transcription factor E4F1 (E4F1) Interacting Protein Interacting Protein Info
UniProt ID
E4F1_HUMAN 
Synonyms E4F
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Yeast two hybrid [34]
Interacting Protein Name E3 ubiquitin-protein ligase HUWE1 (HUWE1) Interacting Protein Interacting Protein Info
UniProt ID
HUWE1_HUMAN 
Synonyms ARF.BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE.B1; UREB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [35]
Interacting Protein Name Histone acetyltransferase KAT2A (KAT2A) Interacting Protein Interacting Protein Info
UniProt ID
KAT2A_HUMAN 
Synonyms GCN5; GCN5L2; PCAF.b; hGCN5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Fluorescence Resonance Energy Transfer [37]
Interacting Protein Name E3 ubiquitin-protein ligase RNF38 (RNF38) Interacting Protein Interacting Protein Info
UniProt ID
RNF38_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Reconstituted Complex [39]
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-Western [40]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [41]
Alpha-type channels [+] 2 Alpha-type channels +
Interacting Target Name Apoptosis regulator BAK (BAK) Literature-reported Target Interacting Protein Info
UniProt ID
BAK_HUMAN 
Synonyms CDN1; Bcl-2-like protein 7; Bcl2like protein 7; Bcl2-L-7; Bcl2L7; Bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [42]
2 Affinity Capture-Western [42]
3 Co-fractionation [43]
4 Reconstituted Complex [42]
Interacting Target Name Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Interacting Protein Info
UniProt ID
B2CL1_HUMAN 
Synonyms Bcl-XL; BCLX; Bcl-2-like protein 1; Bcl2like protein 1; Bcl2-L-1; Bcl2L1; BCL2L; Apoptosis regulator Bcl-X
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Reconstituted Complex [45]
3 Yeast two hybrid [46]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Target Name Apoptosis regulator Bcl-W (BCL-W) Clinical trial Target Interacting Protein Info
UniProt ID
B2CL2_HUMAN 
Synonyms KIAA0271; BCLW; Bcl-2-like protein 2; Bcl2-L-2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Protein-peptide [47]
3 Reconstituted Complex [44]
Interacting Target Name S100 calcium-binding protein A4 (S100A4) Literature-reported Target Interacting Protein Info
UniProt ID
S10A4_HUMAN 
Synonyms Protein S100-A4; Protein Mts1; Placental calcium-binding protein; MTS1; Metastasin; CAPL; Calvasculin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Reconstituted Complex [49]
Carbon-nitrogen hydrolases [+] 4 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Biochemical Activity [51]
3 Co-localization [23]
4 Reconstituted Complex [52]
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Biochemical Activity [54]
3 Reconstituted Complex [54]
Interacting Target Name Peptidyl arginine deiminase type IV (PADI4) Literature-reported Target Interacting Protein Info
UniProt ID
PADI4_HUMAN 
Synonyms Protein-arginine deiminase type-4; Protein-arginine deiminase type IV; Peptidylarginine deiminase IV; PDI5; PADI5; PAD4; HL-60 PAD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Co-localization [55]
3 Reconstituted Complex [55]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Reconstituted Complex [57]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Fluorescence Resonance Energy Transfer [37]
Cullins [+] 2 Cullins +
Interacting Target Name Cullin-7 (CUL-7) Literature-reported Target Interacting Protein Info
UniProt ID
CUL7_HUMAN 
Synonyms KIAA0076
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [58]
2 Affinity Capture-Western [59]
3 Reconstituted Complex [60]
4 Yeast two hybrid [59]
Interacting Protein Name Cullin-9 (CUL9) Interacting Protein Interacting Protein Info
UniProt ID
CUL9_HUMAN 
Synonyms H7AP1; PARC
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [61]
2 Affinity Capture-Western [61]
3 Co-purification [61]
4 Reconstituted Complex [61]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Reconstituted Complex [63]
Interacting Protein Name PP2A subunit A isoform PR65-alpha (PPP2R1A) Interacting Protein Interacting Protein Info
UniProt ID
2AAA_HUMAN 
Synonyms PP2A.Aalpha; PP2AAALPHA; PR65A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [64]
2 Co-localization [23]
FAM proteins [+] 1 FAM proteins +
Interacting Protein Name BRISC complex subunit Abraxas 2 (ABRAXAS2) Interacting Protein Interacting Protein Info
UniProt ID
ABRX2_HUMAN 
Synonyms ABRO1; KIAA0157
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [58]
2 Affinity Capture-Western [65]
3 Reconstituted Complex [65]
Heat shock proteins [+] 6 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [66]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [67]
4 Biochemical Activity [68]
5 Reconstituted Complex [69]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [70]
2 Affinity Capture-MS [21]
3 Affinity Capture-Western [71]
4 Reconstituted Complex [72]
Interacting Target Name Mortalin (HSPA9) Clinical trial Target Interacting Protein Info
UniProt ID
GRP75_HUMAN 
Synonyms Stress-70 protein, mitochondrial; Peptide-binding protein 74; PBP74; mt-HSP70; MOT; HSPA9B; Heat shock 70 kDa protein 9; GRP-75; GRP75; 75 kDa glucose-regulated protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [3]
3 Yeast two hybrid [73]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [71]
Interacting Protein Name Heat shock 70 kDa protein 1B (HSPA1B) Interacting Protein Interacting Protein Info
UniProt ID
HS71B_HUMAN 
Synonyms HSP70.1B; HSP70.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Co-localization [23]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [23]
2 Yeast two hybrid [74]
Isomerases [+] 2 Isomerases +
Interacting Target Name Rotamase Pin1 (PIN1) Clinical trial Target Interacting Protein Info
UniProt ID
PIN1_HUMAN 
Synonyms Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Reconstituted Complex [76]
3 Yeast two hybrid [46]
Interacting Target Name DNA topoisomerase I (TOP1) Successful Target Interacting Protein Info
UniProt ID
TOP1_HUMAN 
Synonyms DNA topoisomerase I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Yeast two hybrid [78]
Kinases [+] 20 Kinases +
Interacting Target Name Aurora kinase A (AURKA) Clinical trial Target Interacting Protein Info
UniProt ID
AURKA_HUMAN 
Synonyms STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [58]
2 Affinity Capture-Western [79]
3 Biochemical Activity [80]
4 Reconstituted Complex [79]
5 Yeast two hybrid [79]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [81]
3 Biochemical Activity [82]
4 Co-localization [23]
5 Reconstituted Complex [69]
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [83]
3 Co-localization [23]
4 Protein-Fragment Complementation Assay [84]
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [85]
2 Biochemical Activity [86]
3 Reconstituted Complex [87]
4 Yeast two hybrid [88]
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [89]
2 Co-localization [90]
3 Protein-peptide [91]
4 Reconstituted Complex [92]
Interacting Target Name Serine/threonine-protein kinase ATR (FRP1) Clinical trial Target Interacting Protein Info
UniProt ID
ATR_HUMAN 
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [93]
2 Biochemical Activity [94]
3 Protein-peptide [91]
4 Reconstituted Complex [95]
Interacting Target Name Homeodomain interacting protein kinase 2 (HIPK2) Literature-reported Target Interacting Protein Info
UniProt ID
HIPK2_HUMAN 
Synonyms Homeodomain-interacting protein kinase 2; hHIPk2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [96]
2 Biochemical Activity [96]
3 Reconstituted Complex [96]
4 Yeast two hybrid [97]
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Biochemical Activity [99]
3 Co-localization [100]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [101]
2 Biochemical Activity [102]
3 Protein-Fragment Complementation Assay [84]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [103]
2 Co-localization [23]
3 Reconstituted Complex [103]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [104]
2 Biochemical Activity [99]
3 Protein-peptide [91]
Interacting Target Name Tyrosine-protein kinase EIF2AK2 (p68) Patented-recorded Target Interacting Protein Info
UniProt ID
E2AK2_HUMAN 
Synonyms Proteinkinase RNA-activated; Protein kinase RNA-activated; Protein kinase R; PRKR; PKR; p68 kinase; P1/eIF-2A protein kinase; Interferon-inducible RNA-dependent protein kinase; Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [105]
2 Biochemical Activity [105]
3 Reconstituted Complex [105]
Interacting Target Name Casein kinase I delta (CSNK1D) Preclinical Target Interacting Protein Info
UniProt ID
KC1D_HUMAN 
Synonyms Tau-protein kinase CSNK1D; HCKID; CKI-delta; CKId; Casein kinase I isoform delta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [106]
2 Biochemical Activity [107]
3 Co-localization [23]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [108]
2 Yeast two hybrid [46]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Biochemical Activity [110]
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [110]
2 Co-localization [23]
Interacting Target Name Cyclin-dependent kinase 7 (CDK7) Clinical trial Target Interacting Protein Info
UniProt ID
CDK7_HUMAN 
Synonyms TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [111]
2 Biochemical Activity [112]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [113]
2 Biochemical Activity [114]
Interacting Target Name MAPK/ERK kinase kinase 1 (MAP3K1) Clinical trial Target Interacting Protein Info
UniProt ID
M3K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 1; Mitogenactivated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [115]
2 Reconstituted Complex [116]
Interacting Protein Name Serine/threonine-protein kinase STK11 (STK11) Interacting Protein Interacting Protein Info
UniProt ID
STK11_HUMAN 
Synonyms LKB1; PJS; hLKB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [117]
2 Fluorescence Resonance Energy Transfer [37]
Nuclear hormone receptors [+] 3 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [118]
2 Reconstituted Complex [119]
Interacting Target Name Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Interacting Protein Info
UniProt ID
HNF4A_HUMAN 
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [58]
2 Reconstituted Complex [120]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [121]
2 Reconstituted Complex [122]
One-carbon transferases [+] 3 One-carbon transferases +
Interacting Target Name Histone-lysine N-methyltransferase SETD7 (SETD7) Literature-reported Target Interacting Protein Info
UniProt ID
SETD7_HUMAN 
Synonyms SET9; SET7/9; SET7; SET domain-containing protein 7; Lysine N-methyltransferase 7; KMT7; KIAA1717; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [123]
2 Co-crystal Structure [124]
3 Yeast two hybrid [125]
Interacting Target Name SET and MYND domain-containing protein 2 (SMYD2) Preclinical Target Interacting Protein Info
UniProt ID
SMYD2_HUMAN 
Synonyms N-lysine methyltransferase SMYD2; Nlysine methyltransferase SMYD2; Lysine N-methyltransferase 3C; Lysine Nmethyltransferase 3C; KMT3C; HSKM-B; HSKMB; Histone methyltransferase SMYD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [126]
2 Biochemical Activity [123]
Interacting Target Name Mixed-lineage leukemia protein (MLL) Literature-reported Target Interacting Protein Info
UniProt ID
KMT2A_HUMAN 
Synonyms Zinc finger protein HRX; Trithorax-like protein; Trithoraxlike protein; p320; p180; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine N-methyltransferase 2A; Lysine Nmethyltransferase 2A; HTRX; HRX; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; CXXCtype zinc finger protein 7; CXXC7; ALL-1; ALL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [127]
Oxidoreductases [+] 2 Oxidoreductases +
Interacting Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target Interacting Protein Info
UniProt ID
PGH2_HUMAN 
Synonyms Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cytochrome c oxidase polypeptide II; Cyclooxygenase-2; COX2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [128]
2 Co-purification [129]
3 Reconstituted Complex [130]
Interacting Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target Interacting Protein Info
UniProt ID
KDM1A_HUMAN 
Synonyms Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [131]
2 Biochemical Activity [132]
3 Reconstituted Complex [131]
Peptidases [+] 4 Peptidases +
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Preclinical Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [133]
2 Affinity Capture-Western [133]
3 Biochemical Activity [133]
4 Co-crystal Structure [134]
5 Protein-peptide [135]
6 Reconstituted Complex [136]
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [137]
2 Far Western [138]
3 Reconstituted Complex [137]
Interacting Protein Name OTU domain-containing protein 5 (OTUD5) Interacting Protein Interacting Protein Info
UniProt ID
OTUD5_HUMAN 
Synonyms DUBA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [139]
2 Reconstituted Complex [139]
3 Yeast two hybrid [139]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 10 (USP10) Interacting Protein Interacting Protein Info
UniProt ID
UBP10_HUMAN 
Synonyms UBPO
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [140]
2 Reconstituted Complex [140]
Proteins 14-3-3 [+] 1 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein sigma (SFN) Interacting Protein Interacting Protein Info
UniProt ID
1433S_HUMAN 
Synonyms YWHAS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Reconstituted Complex [141]
Ribosomal proteins [+] 4 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL5 (RPL11) Interacting Protein Interacting Protein Info
UniProt ID
RL11_HUMAN 
Synonyms DBA7; GIG34; L11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [142]
Interacting Protein Name Large ribosomal subunit protein uL14 (RPL23) Interacting Protein Interacting Protein Info
UniProt ID
RL23_HUMAN 
Synonyms L23; rpL17
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [142]
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [142]
Interacting Protein Name Small ribosomal subunit protein Es10 (RPS10) Interacting Protein Interacting Protein Info
UniProt ID
RS10_HUMAN 
Synonyms DBA9; S10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Yeast two hybrid [143]
Transcription regulators [+] 23 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [144]
2 Affinity Capture-Western [145]
3 Biochemical Activity [146]
4 Co-crystal Structure [147]
5 Co-localization [148]
6 Fluorescence Resonance Energy Transfer [149]
7 Protein-peptide [150]
8 Reconstituted Complex [151]
Interacting Target Name AP-2 transcription factor (TFAP2A) Literature-reported Target Interacting Protein Info
UniProt ID
AP2A_HUMAN 
Synonyms Transcription factor AP-2-alpha; TFAP2; AP2TF; AP2-alpha; AP-2; Activator protein 2; Activating enhancer-binding protein 2-alpha
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [152]
2 Co-localization [152]
3 Reconstituted Complex [153]
4 Yeast two hybrid [152]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [154]
2 Co-localization [155]
3 Reconstituted Complex [156]
Interacting Target Name Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Interacting Protein Info
UniProt ID
CREB1_HUMAN 
Synonyms Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; cAMP-responsive element-binding protein 1; CAMP-response element binding protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [157]
2 Co-localization [23]
3 Reconstituted Complex [158]
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [159]
2 Co-localization [160]
3 Reconstituted Complex [161]
Interacting Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) Literature-reported Target Interacting Protein Info
UniProt ID
ATF3_HUMAN 
Synonyms Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [162]
2 Reconstituted Complex [162]
3 Yeast two hybrid [74]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [163]
2 Co-localization [164]
3 Reconstituted Complex [163]
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [163]
2 Co-localization [23]
3 Reconstituted Complex [163]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [165]
2 Reconstituted Complex [166]
Interacting Target Name Early growth response protein 1 (EGR-1) Clinical trial Target Interacting Protein Info
UniProt ID
EGR1_HUMAN 
Synonyms ZNF225; Zinc finger protein Krox-24; Zinc finger protein Krox24; Zinc finger protein 225; Transcription factor Zif268; Transcription factor ETR103; NGFI-A; NGFIA; Nerve growth factor-induced protein A; Nerve growth factorinduced protein A; KROX24; AT225
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [167]
2 Reconstituted Complex [167]
Interacting Target Name High mobility group protein B1 (HMGB1) Literature-reported Target Interacting Protein Info
UniProt ID
HMGB1_HUMAN 
Synonyms HMG-1; HMG1; High mobility group protein 1; High mobility group box chromosomal protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [168]
2 Reconstituted Complex [168]
Interacting Target Name Twist-related protein 1 (TWIST1) Literature-reported Target Interacting Protein Info
UniProt ID
TWST1_HUMAN 
Synonyms TWIST; H-twist; Class A basic helix-loop-helix protein 38; bHLHa38
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [169]
2 Reconstituted Complex [170]
Interacting Protein Name Cyclin-D-binding Myb-like transcription factor 1 (DMTF1) Interacting Protein Interacting Protein Info
UniProt ID
DMTF1_HUMAN 
Synonyms DMP1; DMTF; MRUL; hDMP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [171]
2 Reconstituted Complex [172]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [173]
2 Co-localization [164]
Interacting Protein Name Zinc finger protein 278 (PATZ1) Interacting Protein Interacting Protein Info
UniProt ID
PATZ1_HUMAN 
Synonyms MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG; dJ400N23
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [174]
2 Reconstituted Complex [174]
Interacting Protein Name Period circadian protein homolog 2 (PER2) Interacting Protein Interacting Protein Info
UniProt ID
PER2_HUMAN 
Synonyms FASPS; FASPS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [175]
2 Reconstituted Complex [176]
Interacting Protein Name SWI/SNF complex subunit SMARCC1 (SMARCC1) Interacting Protein Interacting Protein Info
UniProt ID
SMRC1_HUMAN 
Synonyms BAF155; CRACC1; Rsc8; SRG3; SWI3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [177]
2 Co-fractionation [1]
Interacting Protein Name Transcriptional adapter 3 (TADA3) Interacting Protein Interacting Protein Info
UniProt ID
TADA3_HUMAN 
Synonyms ADA3; NGG1; STAF54; TADA3L; hADA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [36]
Interacting Protein Name TATA-box-binding protein (TBP) Interacting Protein Interacting Protein Info
UniProt ID
TBP_HUMAN 
Synonyms GTF2D; GTF2D1; HDL4; SCA17; TFIID
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [178]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [145]
2 Fluorescence Resonance Energy Transfer [37]
Interacting Protein Name Transcriptional repressor protein YY1 (YY1) Interacting Protein Interacting Protein Info
UniProt ID
TYY1_HUMAN 
Synonyms DELTA; INO80S; NF.E1; UCRBP; YIN.YANG.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [179]
2 Reconstituted Complex [180]
Interacting Protein Name Nuclease-sensitive element-binding protein 1 (YBX1) Interacting Protein Interacting Protein Info
UniProt ID
YBOX1_HUMAN 
Synonyms BP.8; CSDA2; CSDB; DBPB; MDR.NF1; NSEP.1; NSEP1; YB.1; YB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [181]
Interacting Protein Name Zinc finger protein 420 (ZNF420) Interacting Protein Interacting Protein Info
UniProt ID
ZN420_HUMAN 
Synonyms APAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [182]
2 Reconstituted Complex [182]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Luminescence [6]
2 Affinity Capture-MS [58]
3 Affinity Capture-Western [183]
4 Biochemical Activity [184]
5 Co-crystal Structure [185]
6 Co-fractionation [9]
7 Protein-Fragment Complementation Assay [186]
8 Reconstituted Complex [187]
Interacting Target Name Synovial apoptosis inhibitor 1 (SYVN1) Literature-reported Target Interacting Protein Info
UniProt ID
SYVN1_HUMAN 
Synonyms RING-type E3 ubiquitin transferase synoviolin; KIAA1810; HRD1; E3 ubiquitin-protein ligase synoviolin; E3 ubiquitinprotein ligase synoviolin
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [188]
2 Biochemical Activity [189]
3 Co-localization [189]
4 Reconstituted Complex [189]
Interacting Protein Name Ubiquitin conjugation factor E4 B (UBE4B) Interacting Protein Interacting Protein Info
UniProt ID
UBE4B_HUMAN 
Synonyms E4; HDNB1; UBOX3; UFD2; UFD2A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [190]
2 Co-fractionation [191]
3 Reconstituted Complex [191]
Other proteins [+] 33 Other proteins +
Interacting Target Name Tumor suppressor p53-binding protein 1 (TP53BP1) Literature-reported Target Interacting Protein Info
UniProt ID
TP53B_HUMAN 
Synonyms TP53-binding protein 1; p53BP1; p53-binding protein 1; 53BP1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [144]
2 Affinity Capture-Western [192]
3 Co-crystal Structure [193]
4 Co-localization [100]
5 Protein-peptide [194]
6 Reconstituted Complex [195]
7 Yeast two hybrid [196]
Interacting Target Name p53-binding protein Mdm4 (MDM4) Clinical trial Target Interacting Protein Info
UniProt ID
MDM4_HUMAN 
Synonyms Protein Mdmx; p53-binding protein Mdm4; Mdm2-like p53-binding protein; Double minute 4 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [197]
2 Affinity Capture-Western [198]
3 Fluorescence Resonance Energy Transfer [37]
4 Protein-Fragment Complementation Assay [199]
5 Protein-peptide [200]
6 Reconstituted Complex [198]
Interacting Target Name DNA repair protein RAD51 homolog 1 (RAD51) Clinical trial Target Interacting Protein Info
UniProt ID
RAD51_HUMAN 
Synonyms RECA; RAD51A; RAD51 homolog A; HsRAD51; HRAD51
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [201]
2 Affinity Capture-Western [202]
3 Co-purification [201]
4 Reconstituted Complex [203]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [204]
2 Co-localization [23]
3 Reconstituted Complex [205]
4 Yeast two hybrid [204]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [206]
2 Far Western [207]
3 Reconstituted Complex [206]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [208]
2 Far Western [208]
3 Reconstituted Complex [209]
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [210]
3 Reconstituted Complex [211]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [212]
2 Affinity Capture-Western [13]
3 Reconstituted Complex [13]
Interacting Protein Name Apoptosis-stimulating of p53 protein 2 (TP53BP2) Interacting Protein Interacting Protein Info
UniProt ID
ASPP2_HUMAN 
Synonyms 53BP2; ASPP2; BBP; P53BP2; PPP1R13A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [213]
2 Reconstituted Complex [196]
3 Yeast two hybrid [196]
Interacting Protein Name BAG family molecular chaperone regulator 5 (BAG5) Interacting Protein Interacting Protein Info
UniProt ID
BAG5_HUMAN 
Synonyms BAG.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [214]
3 Reconstituted Complex [214]
Interacting Protein Name Coiled-coil domain-containing protein 8 (CCDC8) Interacting Protein Interacting Protein Info
UniProt ID
CCDC8_HUMAN 
Synonyms 3M3; PPP1R20; p90
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [144]
3 Reconstituted Complex [144]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [215]
2 Co-localization [23]
3 Reconstituted Complex [215]
Interacting Protein Name General transcription factor IIH subunit 1 (GTF2H1) Interacting Protein Interacting Protein Info
UniProt ID
TF2H1_HUMAN 
Synonyms BTF2; P62; TFB1; TFIIH
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [41]
2 Far Western [4]
3 Reconstituted Complex [216]
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [217]
2 Co-localization [217]
Interacting Target Name Survival motor neuron protein (SMN1) Successful Target Interacting Protein Info
UniProt ID
SMN_HUMAN 
Synonyms Survival motor neuron protein; SMNT; SMNC; SMN2; SMN; Gemin-1; Component of gems 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [218]
2 Yeast two hybrid [46]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Co-localization [219]
Interacting Target Name Suppressor of cytokine signaling 1 (SOCS1) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS1_HUMAN 
Synonyms TIP-3; TIP3; Tec-interacting protein 3; STAT-induced STAT inhibitor 1; STAT induced STAT inhibitor 1; SSI-1; SSI1; SOCS-1; JAK-binding protein; JAB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [220]
2 Reconstituted Complex [220]
Interacting Protein Name Axin-1 (AXIN1) Interacting Protein Interacting Protein Info
UniProt ID
AXIN1_HUMAN 
Synonyms AXIN; PPP1R49
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [221]
2 Reconstituted Complex [222]
Interacting Protein Name BAG family molecular chaperone regulator 2 (BAG2) Interacting Protein Interacting Protein Info
UniProt ID
BAG2_HUMAN 
Synonyms BAG.2; dJ417I1.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [21]
Interacting Protein Name DnaJ homolog subfamily A member 1 (DNAJA1) Interacting Protein Interacting Protein Info
UniProt ID
DNJA1_HUMAN 
Synonyms DJ.2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [223]
Interacting Protein Name Chimeric ERCC6-PGBD3 protein (CSB-PGBD3) Interacting Protein Interacting Protein Info
UniProt ID
ERPG3_HUMAN 
Synonyms ARMD5; CKN2; COFS; COFS1; CSB; RAD26; UVSS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [224]
2 Reconstituted Complex [5]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein K (HNRNPK) Interacting Protein Interacting Protein Info
UniProt ID
HNRPK_HUMAN 
Synonyms CSBP; HNRPK; TUNP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [225]
Interacting Protein Name RelA-associated inhibitor (PPP1R13L) Interacting Protein Interacting Protein Info
UniProt ID
IASPP_HUMAN 
Synonyms IASPP; NKIP1; RAI; RAI4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [226]
Interacting Protein Name Insulin-like growth factor 2-binding protein 1 (IGF2BP1) Interacting Protein Interacting Protein Info
UniProt ID
IF2B1_HUMAN 
Synonyms CRD.BP; CRDBP; IMP.1; IMP1; VICKZ1; ZBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [38]
Interacting Protein Name Inhibitor of growth protein 4 (ING4) Interacting Protein Interacting Protein Info
UniProt ID
ING4_HUMAN 
Synonyms p29ING4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [227]
2 Reconstituted Complex [228]
Interacting Protein Name Leucine-rich PPR motif-containing protein (LRPPRC) Interacting Protein Interacting Protein Info
UniProt ID
LPPRC_HUMAN 
Synonyms CLONE.23970; GP130; LRP130; LSFC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [38]
Interacting Protein Name Metastasis-associated protein MTA2 (MTA2) Interacting Protein Interacting Protein Info
UniProt ID
MTA2_HUMAN 
Synonyms MTA1L1; PID
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [52]
Interacting Protein Name Necdin (NDN) Interacting Protein Interacting Protein Info
UniProt ID
NECD_HUMAN 
Synonyms HsT16328; PWCR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [229]
2 Reconstituted Complex [230]
Interacting Protein Name Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) Interacting Protein Interacting Protein Info
UniProt ID
PTTG_HUMAN 
Synonyms C21orf1; C21orf3; PBF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [231]
2 Reconstituted Complex [232]
Interacting Protein Name Retinoblastoma-binding protein 5 (RBBP5) Interacting Protein Interacting Protein Info
UniProt ID
RBBP5_HUMAN 
Synonyms RBQ3; SWD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [233]
2 Reconstituted Complex [127]
Interacting Protein Name Replication factor A protein 1 (RPA1) Interacting Protein Interacting Protein Info
UniProt ID
RFA1_HUMAN 
Synonyms HSSB; MST075; REPA1; RF.A; RP.A; RPA70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [234]
2 Reconstituted Complex [234]
Interacting Protein Name Transcription initiation factor TFIID subunit 9 (TAF9) Interacting Protein Interacting Protein Info
UniProt ID
TAF9_HUMAN 
Synonyms MGC:5067; STAF31/32; TAF2G; TAFII.31; TAFII.32; TAFII31; TAFII32; TAFIID32
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [235]
Interacting Protein Name WW domain-containing oxidoreductase (WWOX) Interacting Protein Interacting Protein Info
UniProt ID
WWOX_HUMAN 
Synonyms D16S432E; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [236]
2 Yeast two hybrid [236]
References  Top
REF 1 SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem. 2002 Jun 21;277(25):22330-7.
REF 2 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 3 Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. FEBS Lett. 2007 Jan 9;581(1):131-9.
REF 4 Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. EMBO J. 1996 Apr 1;15(7):1615-24.
REF 5 p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet. 1995 Jun;10(2):188-95.
REF 6 Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10(12):1321-8.
REF 7 Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science. 2003 Apr 11;300(5617):342-4.
REF 8 Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5762-7.
REF 9 p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct;2(4):405-15.
REF 10 Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19;387(6635):823-7.
REF 11 Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7009-14.
REF 12 Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004 Jun 11;117(6):735-48.
REF 13 p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell. 2006 May 5;22(3):395-405.
REF 14 MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem. 2002 Aug 23;277(34):30838-43.
REF 15 p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol. 1999 Feb;19(2):1202-9.
REF 16 PCAF is a coactivator for p73-mediated transactivation. Oncogene. 2003 Nov 13;22(51):8316-29.
REF 17 Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature. 2016 Jan 28;529(7587):541-5.
REF 18 Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8797-801.
REF 19 Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol. 1993 Feb;13(2):775-84.
REF 20 The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004 May 6;429(6987):86-92.
REF 21 Autophagic degradation of the inhibitory p53 isoform 133p53 as a regulatory mechanism for p53-mediated senescence. Nat Commun. 2014 Aug 21;5:4706.
REF 22 CHIP chaperones wild type p53 tumor suppressor protein. J Biol Chem. 2007 Sep 28;282(39):28441-54.
REF 23 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 24 Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol Cell. 2001 Sep;8(3):713-8.
REF 25 MBP1: a novel mutant p53-specific protein partner with oncogenic properties. Oncogene. 1999 Jun 17;18(24):3608-16.
REF 26 Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2872-7.
REF 27 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.
REF 28 The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression. PLoS One. 2011;6(7):e22785.
REF 29 Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability. Biochem Biophys Res Commun. 2003 Feb 7;301(2):392-8.
REF 30 EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem. 2011 Apr 29;286(17):14972-82.
REF 31 BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression. J Biol Chem. 2009 Aug 21;284(34):22970-7.
REF 32 TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro. Avicenna J Med Biotechnol. 2015 Apr-Jun;7(2):76-9.
REF 33 Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem. 2003 Feb 14;278(7):4981-9.
REF 34 p53 is involved in the p120E4F-mediated growth arrest. Oncogene. 2000 Jan 13;19(2):188-99.
REF 35 ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell. 2005 Jul 1;121(7):1071-83.
REF 36 Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. Mol Cell Biol. 2008 Apr;28(8):2517-27.
REF 37 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 38 A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6322-7.
REF 39 RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. Biochem Biophys Res Commun. 2013 Nov 1;440(4):473-8.
REF 40 Bladder polypoid cystitis-derived A20 associates with tumorigenesis. Cell Biochem Biophys. 2013 Nov;67(2):669-73.
REF 41 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell. 2006 Jun 23;22(6):731-40.
REF 42 Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004 May;6(5):443-50.
REF 43 Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 2011 Aug 19;286(33):28749-60.
REF 44 Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins. Oncotarget. 2014 Sep 30;5(18):8452-65.
REF 45 Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev. 2010 Oct 1;24(19):2194-204.
REF 46 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 47 Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins. Biochem Biophys Res Commun. 2014 Feb 28;445(1):120-5.
REF 48 Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell invasiveness. Biochem J. 2010 Feb 24;426(3):327-35.
REF 49 Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). Biochem Biophys Res Commun. 2001 Sep 7;286(5):1212-7.
REF 50 Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene. 2001 Jan 11;20(2):240-51.
REF 51 Histone deacetylases specifically down-regulate p53-dependent gene activation. J Biol Chem. 2000 Jul 7;275(27):20436-43.
REF 52 Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature. 2000 Nov 16;408(6810):377-81.
REF 53 Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. J Biol Chem. 2011 Feb 25;286(8):6311-20.
REF 54 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 2002 May 15;21(10):2383-96.
REF 55 Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol. 2008 Aug;28(15):4745-58.
REF 56 Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J. 2004 Mar 10;23(5):1144-54.
REF 57 Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression. Oncogene. 2010 May 27;29(21):3153-62.
REF 58 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 59 Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding. Biochim Biophys Acta. 2007 Mar;1773(3):358-66.
REF 60 CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007 Oct 15;67(20):9616-22.
REF 61 Parc: a cytoplasmic anchor for p53. Cell. 2003 Jan 10;112(1):29-40.
REF 62 PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003 Feb;3(2):117-30.
REF 63 p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Cell Death Differ. 2014 Jan;21(1):146-60.
REF 64 Identification of novel p53-binding proteins by biomolecular interaction analysis combined with tandem mass spectrometry. Mol Biotechnol. 2003 Mar;23(3):203-12.
REF 65 ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. Nat Commun. 2014 Oct 6;5:5059.
REF 66 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 67 Phosphorylation and hsp90 binding mediate heat shock stabilization of p53. J Biol Chem. 2003 Jan 17;278(3):2066-71.
REF 68 Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol. 2004 Mar 12;337(1):129-45.
REF 69 Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem. 2004 Nov 19;279(47):48836-45.
REF 70 HSP90 Shapes the Consequences of Human Genetic Variation. Cell. 2017 Feb 23;168(5):856-866.e12.
REF 71 p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cell lines. Cancer Lett. 1994 Nov 25;87(1):39-46.
REF 72 A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135). J Biol Chem. 2001 May 4;276(18):14649-57.
REF 73 Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res. 2002 Apr 1;274(2):246-53.
REF 74 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 75 The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 2002 Oct 24;419(6909):853-7.
REF 76 Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 2002 Dec 13;277(50):47976-9.
REF 77 The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10355-60.
REF 78 Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1235-40.
REF 79 Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J. 2002 Sep 2;21(17):4491-9.
REF 80 A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2. Biochim Biophys Acta. 2013 Feb;1834(2):508-15.
REF 81 COP9 subunits 4 and 5 target soluble guanylyl cyclase 1 and p53 in prostate cancer cells. Mol Endocrinol. 2014 Jun;28(6):834-45.
REF 82 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 2003 Mar 17;22(6):1302-12.
REF 83 Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway. J Biol Chem. 2011 Mar 11;286(10):8565-76.
REF 84 Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J. 2011 Sep 15;438(3):495-503.
REF 85 JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. Oncogene. 1997 Nov 6;15(19):2277-87.
REF 86 Control of p53 multimerization by Ubc13 is JNK-regulated. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12676-81.
REF 87 The effect of C-terminal fragment of JNK2 on the stability of p53 and cell proliferation. Cell Res. 2004 Oct;14(5):434-8.
REF 88 JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. J Biol Chem. 2003 Mar 14;278(11):9195-202.
REF 89 ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998 Dec;20(4):398-400.
REF 90 The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling. J Immunol. 2016 Oct 1;197(7):2918-29.
REF 91 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.
REF 92 Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol. 2005 Jan;25(2):661-70.
REF 93 Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69.
REF 94 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15;15(14):1833-44.
REF 95 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004 Jul 23;279(30):31251-8.
REF 96 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002 Jan;4(1):1-10.
REF 97 Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J Biol Chem. 2002 Aug 30;277(35):32020-8.
REF 98 Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia. 2002 Mar-Apr;4(2):171-80.
REF 99 Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. J Biol Chem. 2003 Aug 8;278(32):29940-7.
REF 100 Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004 Sep 13;166(6):801-13.
REF 101 UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate. FEBS Lett. 2010 Dec 1;584(23):4711-6.
REF 102 Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. J Exp Med. 2005 Jan 17;201(2):279-89.
REF 103 Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18;29(1):9-22.
REF 104 Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. Pharmacogenomics J. 2010 Apr;10(2):94-104.
REF 105 The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene. 1999 Apr 29;18(17):2690-702.
REF 106 PML enhances the regulation of p53 by CK1 in response to DNA damage. Oncogene. 2008 Jun 12;27(26):3653-61.
REF 107 Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett. 2006 Nov 27;580(27):6477-84.
REF 108 Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7951-5.
REF 109 Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2). Biochem Biophys Res Commun. 2001 May 4;283(2):507-12.
REF 110 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. J Mol Biol. 2000 Jul 14;300(3):503-18.
REF 111 Regulation of CAK kinase activity by p53. Oncogene. 1998 Nov 26;17(21):2733-41.
REF 112 p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol. 1997 Dec;17(12):7220-9.
REF 113 The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41.
REF 114 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 2000 Feb 1;14(3):289-300.
REF 115 MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem. 2010 Dec 10;285(50):38818-31.
REF 116 Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1). J Cell Biochem. 2015 Dec;116(12):2903-14.
REF 117 The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell. 2001 Jun;7(6):1307-19.
REF 118 Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. Int J Biochem Cell Biol. 2016 Jan;70:105-17.
REF 119 Estrogen receptor protects p53 from deactivation by human double minute-2. Cancer Res. 2000 Apr 1;60(7):1810-4.
REF 120 Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Mol Endocrinol. 2002 Feb;16(2):402-10.
REF 121 An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability. FEBS Lett. 2012 Apr 24;586(8):1135-40.
REF 122 Cross-regulation of protein stability by p53 and nuclear receptor SHP. PLoS One. 2012;7(6):e39789.
REF 123 Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006 Nov 30;444(7119):629-32.
REF 124 Regulation of p53 activity through lysine methylation. Nature. 2004 Nov 18;432(7015):353-60.
REF 125 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 126 The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics. 2008 Mar;7(3):560-72.
REF 127 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell. 2005 Jun 17;121(6):873-85.
REF 128 Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. Oncogene. 2001 Oct 18;20(47):6864-70.
REF 129 Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. Biochim Biophys Acta. 2009 Aug;1793(8):1354-65.
REF 130 COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun. 2005 Mar 25;328(4):1107-12.
REF 131 p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep;28(17):5139-46.
REF 132 p53 is regulated by the lysine demethylase LSD1. Nature. 2007 Sep 6;449(7158):105-8.
REF 133 Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr 11;416(6881):648-53.
REF 134 Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 2006 Mar;13(3):285-91.
REF 135 Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. J Mol Biol. 2010 Oct 8;402(5):825-37.
REF 136 C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site. Arch Biochem Biophys. 2010 Nov 15;503(2):207-12.
REF 137 Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 1;103(4):1219-30.
REF 138 COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001 Apr 2;20(7):1630-9.
REF 139 OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One. 2013 Oct 15;8(10):e77682.
REF 140 USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010 Feb 5;140(3):384-96.
REF 141 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol. 2003 Oct;23(20):7096-107.
REF 142 Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004 Oct 22;279(43):44475-82.
REF 143 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem. 2005 Jan 14;280(2):1543-51.
REF 144 Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18937-42.
REF 145 Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell. 2007 Apr 13;26(1):75-87.
REF 146 Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011 Mar 10;471(7337):189-95.
REF 147 Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1853-62.
REF 148 Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Am J Physiol Renal Physiol. 2005 May;288(5):F899-909.
REF 149 Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. Biochemistry. 2009 Feb 17;48(6):1244-55.
REF 150 Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19290-5.
REF 151 CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res. 1997 Sep 1;57(17):3693-6.
REF 152 Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem. 2002 Nov 22;277(47):45028-33.
REF 153 AP2alpha alters the transcriptional activity and stability of p53. Oncogene. 2006 Apr 6;25(15):2148-59.
REF 154 Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1. J Biol Chem. 1993 Apr 15;268(11):7923-8.
REF 155 DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. Mol Cell. 2004 Dec 3;16(5):725-36.
REF 156 The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol. 2003 Apr;23(8):2669-79.
REF 157 CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. Biochem Biophys Res Commun. 2011 Mar 4;406(1):79-84.
REF 158 p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol Cell Biol. 2000 Jul;20(13):4849-58.
REF 159 Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncol Rep. 2007 Nov;18(5):1311-4.
REF 160 Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem. 2010 Mar 26;285(13):10044-52.
REF 161 The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J Biol Chem. 2003 Oct 24;278(43):42560-8.
REF 162 ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem. 2002 Mar 29;277(13):10804-12.
REF 163 Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell. 2003 May 2;113(3):301-14.
REF 164 Differential regulation of the REG-proteasome pathway by p53/TGF- signalling and mutant p53 in cancer cells. Nat Commun. 2013;4:2667.
REF 165 Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem. 2003 Apr 18;278(16):13595-8.
REF 166 Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9.
REF 167 Physical interaction between p53 and primary response gene Egr-1. Int J Oncol. 2001 Apr;18(4):863-70.
REF 168 Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein. J Biol Chem. 2001 Mar 9;276(10):7534-40.
REF 169 A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. Cancer Cell. 2012 Sep 11;22(3):404-15.
REF 170 Twist and p53 reciprocally regulate target genes via direct interaction. Oncogene. 2008 Sep 18;27(42):5543-53.
REF 171 Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function. Cancer Res. 2012 Apr 1;72(7):1740-50.
REF 172 Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1. Cancer Invest. 2017 May 28;35(5):301-312.
REF 173 Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol. 2008 Dec;15(12):1246-54.
REF 174 PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. Cell Death Dis. 2013 Dec 12;4:e963.
REF 175 The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells. Mol Biol Cell. 2014 Oct 1;25(19):3081-93.
REF 176 Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13516-13521.
REF 177 BAF60a interacts with p53 to recruit the SWI/SNF complex. J Biol Chem. 2008 May 2;283(18):11924-34.
REF 178 Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J Virol. 1994 Oct;68(10):6223-31.
REF 179 YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12165-70.
REF 180 Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol. 2012 May;180(5):2120-33.
REF 181 Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression. Oncogene. 2000 Dec 14;19(54):6194-202.
REF 182 KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol. 2009 May;11(5):580-91.
REF 183 NUMB controls p53 tumour suppressor activity. Nature. 2008 Jan 3;451(7174):76-80.
REF 184 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. Nat Commun. 2014 Nov 11;5:5426.
REF 185 Binding induced folding in p53-MDM2 complex. J Am Chem Soc. 2007 Mar 14;129(10):2930-7.
REF 186 Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells. Nat Methods. 2005 Jun;2(6):427-33.
REF 187 Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992 Jul 2;358(6381):80-3.
REF 188 Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol. 2011 Dec 1;82(11):1630-40.
REF 189 Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 2007 Jan 10;26(1):113-22.
REF 190 Regulation of p53 level by UBE4B in breast cancer. PLoS One. 2014 Feb 26;9(2):e90154.
REF 191 UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nat Med. 2011 Mar;17(3):347-55.
REF 192 The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cell Signal. 2015 Sep;27(9):1763-71.
REF 193 Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J. 2002 Jul 15;21(14):3863-72.
REF 194 An acetyl-methyl switch drives a conformational change in p53. Structure. 2015 Feb 3;23(2):322-31.
REF 195 Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. Protein Sci. 2004 Mar;13(3):617-25.
REF 196 Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6098-102.
REF 197 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 198 A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16;18(5):411-22.
REF 199 A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11;9(5):1946-1958.
REF 200 Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene. 2016 Apr 14;35(15):1919-25.
REF 201 Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003 Nov;12(5):1087-99.
REF 202 HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene. 2007 Jan 25;26(4):477-86.
REF 203 p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 1996 Apr 15;15(8):1992-2002.
REF 204 Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. Nucleic Acids Res. 2003 Sep 15;31(18):5356-67.
REF 205 Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. Mol Cell Biol. 2003 Jan;23(1):322-34.
REF 206 ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 1997 Oct 1;16(19):6018-33.
REF 207 Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J Biol Chem. 1998 May 8;273(19):11839-43.
REF 208 Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol. 2002 Aug;22(16):6014-22.
REF 209 HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 2015 Aug 4;5:12793.
REF 210 Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol. 2002 Jul;4(7):529-33.
REF 211 Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation. FEBS Lett. 2006 Jan 9;580(1):345-50.
REF 212 Proteomic dissection of the von Hippel-Lindau (VHL) interactome. J Proteome Res. 2011 Nov 4;10(11):5175-82.
REF 213 Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40.
REF 214 A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov. 2016 Nov 1;2:16039.
REF 215 The function of PML in p53-dependent apoptosis. Nat Cell Biol. 2000 Oct;2(10):730-6.
REF 216 Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. Mol Cell Biol. 1994 Oct;14(10):7013-24.
REF 217 DNA damage tolerance pathway involving DNA polymerase and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4311-9.
REF 218 A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. J Biol Chem. 2002 Jan 25;277(4):2852-9.
REF 219 Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 6;538(7623):118-122.
REF 220 SOCS1 links cytokine signaling to p53 and senescence. Mol Cell. 2009 Dec 11;36(5):754-67.
REF 221 AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene. 2011 Mar 10;30(10):1194-204.
REF 222 MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity. PLoS One. 2013 Jun 27;8(6):e67529.
REF 223 DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016 Nov;18(11):1233-1243.
REF 224 Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. Mol Cell. 2000 May;5(5):801-10.
REF 225 SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. EMBO J. 2012 Nov 28;31(23):4441-52.
REF 226 iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet. 2003 Feb;33(2):162-7.
REF 227 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res. 2003 May 15;63(10):2373-8.
REF 228 Nuclear localization signal of ING4 plays a key role in its binding to p53. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1032-8.
REF 229 Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner. J Neurosci. 2013 Jun 19;33(25):10362-73.
REF 230 Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem. 1999 Jun 4;274(23):16242-8.
REF 231 The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. Mol Carcinog. 2016 Jan;55(1):15-26.
REF 232 The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology. 2014 Apr;155(4):1222-34.
REF 233 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 2013 Jul 18;154(2):297-310.
REF 234 The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene. 2004 Dec 2;23(56):9025-33.
REF 235 Human TAFII31 protein is a transcriptional coactivator of the p53 protein. Proc Natl Acad Sci U S A. 1995 May 23;92(11):5154-8.
REF 236 Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem. 2001 Feb 2;276(5):3361-70.

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