Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | DNA topoisomerase 1 (TOP1) | Successful | Target Info | ||
| UniProt ID | TOP1_HUMAN | ||||
| Gene Name | TOP1 | ||||
| Gene ID | 7150 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [2] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [3] | ||
| Nucleolin (NCL) | Target Info | PPI Info | [1] | ||
| Spliceosome-associated protein 155 (SF3B1) | Target Info | PPI Info | [1] | ||
| Interacting Literature-reported Target(s) | X-ray repair cross-complementing 5 (Ku80) | Target Info | PPI Info | [4] | |
| Multiple tumor suppressor 1 (CDKN2A) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Proteomic analysis of complexes formed by human topoisomerase I. Biochim Biophys Acta. 2005 May 20;1749(1):133-41. | ||||
| REF 2 | A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2. Cell Signal. 2014 Jun;26(6):1243-57. | ||||
| REF 3 | The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10355-60. | ||||
| REF 4 | Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011 Jun 16;10:74. | ||||
| REF 5 | Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes. Oncogene. 2004 Oct 21;23(49):8097-104. | ||||
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