Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T06475 Target Info
Target Name Nucleolin (NCL)
Synonyms Protein C23
Target Type Clinical trial Target
Gene Name NCL
UniProt ID
NUCL_HUMAN 
Target Interacting Proteins  Top
Isomerases [+] 1 Isomerases +
Interacting Target Name DNA topoisomerase I (TOP1) Successful Target Interacting Protein Info
UniProt ID
TOP1_HUMAN 
Synonyms DNA topoisomerase I
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
Kinases [+] 3 Kinases +
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [3]
2 Co-fractionation [4]
Interacting Protein Name DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Interacting Protein Interacting Protein Info
UniProt ID
RPAC1_HUMAN 
Synonyms RPA39; RPA40; RPA5; RPAC1; TCS3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [4]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [6]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Reconstituted Complex [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Far Western [9]
3 Reconstituted Complex [10]
Ribosomal proteins [+] 24 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL5 (RPL11) Interacting Protein Interacting Protein Info
UniProt ID
RL11_HUMAN 
Synonyms DBA7; GIG34; L11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL14 (RPL14) Interacting Protein Interacting Protein Info
UniProt ID
RL14_HUMAN 
Synonyms CAG.ISL.7; CTG.B33; L14; RL14; hRL14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL15 (RPL15) Interacting Protein Interacting Protein Info
UniProt ID
RL15_HUMAN 
Synonyms DBA12; EC45; L15; RPL10; RPLY10; RPYL10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL18 (RPL18) Interacting Protein Interacting Protein Info
UniProt ID
RL18_HUMAN 
Synonyms L18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL20 (RPL18A) Interacting Protein Interacting Protein Info
UniProt ID
RL18A_HUMAN 
Synonyms L18A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL19 (RPL19) Interacting Protein Interacting Protein Info
UniProt ID
RL19_HUMAN 
Synonyms L19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL21 (RPL21) Interacting Protein Interacting Protein Info
UniProt ID
RL21_HUMAN 
Synonyms HYPT12; L21
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein eL24 (RPL24) Interacting Protein Interacting Protein Info
UniProt ID
RL24_HUMAN 
Synonyms HEL.S.310; L24
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL3 (RPL3) Interacting Protein Interacting Protein Info
UniProt ID
RL3_HUMAN 
Synonyms ASC.1; L3; TARBP.B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL4 (RPL4) Interacting Protein Interacting Protein Info
UniProt ID
RL4_HUMAN 
Synonyms L4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [4]
Interacting Protein Name Large ribosomal subunit protein eL6 (RPL6) Interacting Protein Interacting Protein Info
UniProt ID
RL6_HUMAN 
Synonyms L6; SHUJUN.2; TAXREB107; TXREB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL30 (RPL7) Interacting Protein Interacting Protein Info
UniProt ID
RL7_HUMAN 
Synonyms L7; humL7.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [4]
Interacting Protein Name Large ribosomal subunit protein eL8 (RPL7A) Interacting Protein Interacting Protein Info
UniProt ID
RL7A_HUMAN 
Synonyms L7A; SURF3; TRUP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL2 (RPL8) Interacting Protein Interacting Protein Info
UniProt ID
RL8_HUMAN 
Synonyms L8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Large ribosomal subunit protein uL6 (RPL9) Interacting Protein Interacting Protein Info
UniProt ID
RL9_HUMAN 
Synonyms L9; NPC.A.16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein uS9 (RPS16) Interacting Protein Interacting Protein Info
UniProt ID
RS16_HUMAN 
Synonyms S16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein uS12 (RPS23) Interacting Protein Interacting Protein Info
UniProt ID
RS23_HUMAN 
Synonyms S23
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein eS24 (RPS24) Interacting Protein Interacting Protein Info
UniProt ID
RS24_HUMAN 
Synonyms DBA3; S24
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein eS26 (RPS26) Interacting Protein Interacting Protein Info
UniProt ID
RS26_HUMAN 
Synonyms DBA10; S26
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein eS1 (RPS3A) Interacting Protein Interacting Protein Info
UniProt ID
RS3A_HUMAN 
Synonyms FTE1; MFTL; S3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Single copy abundant protein (RPS4X) Interacting Protein Interacting Protein Info
UniProt ID
RS4X_HUMAN 
Synonyms CCG2; DXS306; RPS4; S4; SCAR; SCR10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein eS6 (RPS6) Interacting Protein Interacting Protein Info
UniProt ID
RS6_HUMAN 
Synonyms S6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [11]
Interacting Protein Name Small ribosomal subunit protein eS8 (RPS8) Interacting Protein Interacting Protein Info
UniProt ID
RS8_HUMAN 
Synonyms S8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
Other proteins [+] 2 Other proteins +
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-fractionation [15]
3 Reconstituted Complex [14]
Interacting Protein Name Probable rRNA-processing protein EBP2 (EBNA1BP2) Interacting Protein Interacting Protein Info
UniProt ID
EBP2_HUMAN 
Synonyms EBP2; NOBP; P40
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [4]
References  Top
REF 1 Proteomic analysis of complexes formed by human topoisomerase I. Biochim Biophys Acta. 2005 May 20;1749(1):133-41.
REF 2 Identification of a nucleolin binding site in human topoisomerase I. J Biol Chem. 1996 Jan 26;271(4):1993-7.
REF 3 A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches. J Proteome Res. 2016 May 6;15(5):1659-69.
REF 6 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin Cancer Res. 2014 Jul 1;20(13):3496-506.
REF 7 Identification of proteins associated with ligand-activated estrogen receptor in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Proteomics. 2011 Jan;11(1):172-9.
REF 8 Proteomics analysis of the estrogen receptor alpha receptosome. Mol Cell Proteomics. 2010 Jul;9(7):1411-22.
REF 9 Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol. 2002 Aug;22(16):6014-22.
REF 10 HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 2015 Aug 4;5:12793.
REF 11 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 12 Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene. 2006 Nov 23;25(55):7274-88.
REF 13 Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. FEBS J. 2012 Feb;279(3):370-83.
REF 14 C23 interacts with B23, a putative nucleolar-localization-signal-binding protein. Eur J Biochem. 1996 Apr 1;237(1):153-8.
REF 15 Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. Nucleic Acids Res. 2012 Jun;40(11):4861-78.

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