Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
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Target General Information  Top
Target ID T00176 Target Info
Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2)
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Target Type Clinical trial Target
Gene Name MDM2
Biochemical Class Acyltransferase
UniProt ID
MDM2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
4 Reconstituted Complex [2]
Interacting Protein Name Elongation factor 1-alpha 1 (EEF1A1) Interacting Protein Interacting Protein Info
UniProt ID
EF1A1_HUMAN 
Synonyms CCS.3; CCS3; EE1A1; EEF.1; EEF1A; EF.Tu; EF1A; GRAF.1EF; HNGC:16303; LENG7; PTI1; eEF1A.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
Interacting Protein Name Guanine nucleotide-binding protein-like 3 (GNL3) Interacting Protein Interacting Protein Info
UniProt ID
GNL3_HUMAN 
Synonyms C77032; E2IG3; NNP47; NS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-fractionation [8]
Acyltransferases [+] 9 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-peptide [10]
3 Reconstituted Complex [11]
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [12]
3 Reconstituted Complex [13]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-fractionation [15]
3 Reconstituted Complex [14]
Interacting Target Name Transcription intermediary factor 1-beta (TRIM28) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1B_HUMAN 
Synonyms Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [16]
Interacting Protein Name Histone acetyltransferase KAT5 (KAT5) Interacting Protein Interacting Protein Info
UniProt ID
KAT5_HUMAN 
Synonyms ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5; cPLA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Interacting Protein Name E3 ubiquitin-protein ligase RBBP6 (RBBP6) Interacting Protein Interacting Protein Info
UniProt ID
RBBP6_HUMAN 
Synonyms P2P.R; PACT; RBQ.1; SNAMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [20]
Interacting Protein Name Transcription initiation factor TFIID subunit 1 (TAF1) Interacting Protein Interacting Protein Info
UniProt ID
TAF1_HUMAN 
Synonyms BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; N.TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII.250; TAFII250; XDP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Interacting Protein Name NEDD8-conjugating enzyme Ubc12 (UBE2M) Interacting Protein Interacting Protein Info
UniProt ID
UBC12_HUMAN 
Synonyms UBC.RS2; UBC12; hUbc12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Reconstituted Complex [24]
Interacting Protein Name RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) Interacting Protein Interacting Protein Info
UniProt ID
ZN363_HUMAN 
Synonyms ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Reconstituted Complex [26]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Co-localization [28]
3 Reconstituted Complex [27]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [30]
3 Fluorescence Resonance Energy Transfer [31]
4 Protein-peptide [32]
5 Reconstituted Complex [30]
Heat shock proteins [+] 3 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [33]
3 Co-purification [34]
4 Protein-peptide [35]
5 Reconstituted Complex [34]
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [37]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [33]
Isomerases [+] 1 Isomerases +
Interacting Target Name DNA topoisomerase I (TOP1) Successful Target Interacting Protein Info
UniProt ID
TOP1_HUMAN 
Synonyms DNA topoisomerase I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [38]
Kinases [+] 12 Kinases +
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Biochemical Activity [39]
3 Protein-peptide [23]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Biochemical Activity [41]
3 Co-localization [42]
Interacting Target Name Telomerase reverse transcriptase (TERT) Clinical trial Target Interacting Protein Info
UniProt ID
TERT_HUMAN 
Synonyms TRT; TP2; Telomerase-associated protein 2; Telomerase catalytic subunit; TCS1; HEST2; EST2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Biochemical Activity [43]
3 Reconstituted Complex [43]
Interacting Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target Interacting Protein Info
UniProt ID
IGF1R_HUMAN 
Synonyms Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Biochemical Activity [45]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Reconstituted Complex [47]
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Biochemical Activity [49]
Interacting Target Name Beta-adrenergic receptor kinase 1 (ADRBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
ARBK1_HUMAN 
Synonyms GRK2; G-protein coupled receptor kinase 2; Beta-ARK-1; BetaARK1; Beta ARK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [50]
2 Affinity Capture-Western [51]
Interacting Target Name Death-associated protein kinase 3 (DAPK3) Literature-reported Target Interacting Protein Info
UniProt ID
DAPK3_HUMAN 
Synonyms Zipper-interacting protein kinase; ZIP-kinase; ZIPK; MYPT1 kinase; Dlk; DAP-like kinase; DAP kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [35]
2 Co-localization [52]
Interacting Target Name Casein kinase I delta (CSNK1D) Preclinical Target Interacting Protein Info
UniProt ID
KC1D_HUMAN 
Synonyms Tau-protein kinase CSNK1D; HCKID; CKI-delta; CKId; Casein kinase I isoform delta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Biochemical Activity [54]
Interacting Target Name Homeodomain interacting protein kinase 2 (HIPK2) Literature-reported Target Interacting Protein Info
UniProt ID
HIPK2_HUMAN 
Synonyms Homeodomain-interacting protein kinase 2; hHIPk2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Biochemical Activity [56]
Interacting Protein Name Serine/threonine-protein kinase PAK 6 (PAK6) Interacting Protein Interacting Protein Info
UniProt ID
PAK6_HUMAN 
Synonyms PAK5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [58]
Interacting Target Name Pyruvate kinase M2 (PKM) Clinical trial Target Interacting Protein Info
UniProt ID
KPYM_HUMAN 
Synonyms Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase PKM; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase 2/3; PKM2; PK3; PK2; p58; Opa-interacting protein 3; OIP-3; OIP3; Cytosolic thyroid hormone-binding protein; CTHBP
Evidence Score (E-score) 1 Experimental Evidences +
1 Reconstituted Complex [37]
Nuclear hormone receptors [+] 3 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Biochemical Activity [59]
3 Co-localization [28]
4 Reconstituted Complex [60]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Reconstituted Complex [61]
3 Yeast two hybrid [62]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Co-localization [64]
Peptidases [+] 3 Peptidases +
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Preclinical Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [65]
3 Co-crystal Structure [66]
4 Co-fractionation [67]
5 Protein-peptide [67]
6 Reconstituted Complex [68]
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [69]
2 Co-localization [42]
Interacting Protein Name Proteasome subunit alpha type-7 (PSMA7) Interacting Protein Interacting Protein Info
UniProt ID
PSA7_HUMAN 
Synonyms C6; HSPC; RC6.1; XAPC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Co-fractionation [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
3 Co-crystal Structure [73]
4 Co-fractionation [14]
5 Protein-Fragment Complementation Assay [74]
6 Reconstituted Complex [71]
Proteasome components [+] 1 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [75]
Proteins 14-3-3 [+] 2 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein sigma (SFN) Interacting Protein Interacting Protein Info
UniProt ID
1433S_HUMAN 
Synonyms YWHAS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [76]
2 Reconstituted Complex [76]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Reconstituted Complex [78]
Ribosomal proteins [+] 6 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL5 (RPL11) Interacting Protein Interacting Protein Info
UniProt ID
RL11_HUMAN 
Synonyms DBA7; GIG34; L11
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [80]
3 Co-fractionation [81]
4 Co-purification [82]
5 Reconstituted Complex [83]
6 Yeast two hybrid [84]
Interacting Protein Name Large ribosomal subunit protein uL24 (RPL26) Interacting Protein Interacting Protein Info
UniProt ID
RL26_HUMAN 
Synonyms DBA11; L26
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [85]
2 Biochemical Activity [86]
3 Co-localization [85]
4 Reconstituted Complex [85]
5 Yeast two hybrid [85]
Interacting Protein Name Large ribosomal subunit protein uL14 (RPL23) Interacting Protein Interacting Protein Info
UniProt ID
RL23_HUMAN 
Synonyms L23; rpL17
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [87]
3 Co-fractionation [88]
4 Reconstituted Complex [88]
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [89]
3 Co-fractionation [81]
4 Reconstituted Complex [83]
Interacting Protein Name Small ribosomal subunit protein eS7 (RPS7) Interacting Protein Interacting Protein Info
UniProt ID
RS7_HUMAN 
Synonyms DBA8; S7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [90]
2 Reconstituted Complex [90]
3 Yeast two hybrid [90]
Interacting Protein Name Small ribosomal subunit protein uS10 (RPS20) Interacting Protein Interacting Protein Info
UniProt ID
RS20_HUMAN 
Synonyms S20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [91]
Transcription regulators [+] 14 Transcription regulators +
Interacting Target Name Interferon regulatory factor 1 (IRF1) Literature-reported Target Interacting Protein Info
UniProt ID
IRF1_HUMAN 
Synonyms IRF-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [92]
2 Biochemical Activity [93]
3 Protein-peptide [38]
4 Reconstituted Complex [93]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Biochemical Activity [95]
3 Reconstituted Complex [96]
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [97]
2 Biochemical Activity [98]
3 Reconstituted Complex [99]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [100]
2 Reconstituted Complex [100]
3 Yeast two hybrid [84]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [101]
2 Biochemical Activity [102]
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [103]
2 Biochemical Activity [104]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [105]
2 Biochemical Activity [106]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Yeast two hybrid [84]
Interacting Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) Literature-reported Target Interacting Protein Info
UniProt ID
ATF3_HUMAN 
Synonyms Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [108]
2 Reconstituted Complex [108]
Interacting Protein Name Forkhead box protein O4 (FOXO4) Interacting Protein Interacting Protein Info
UniProt ID
FOXO4_HUMAN 
Synonyms AFX; AFX1; MLLT7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Biochemical Activity [109]
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [110]
Interacting Protein Name Interferon regulatory factor 2 (IRF2) Interacting Protein Interacting Protein Info
UniProt ID
IRF2_HUMAN 
Synonyms IRF.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [111]
2 Protein-peptide [38]
Interacting Protein Name Tumor protein 63 (TP63) Interacting Protein Interacting Protein Info
UniProt ID
P63_HUMAN 
Synonyms AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [113]
Interacting Protein Name Forkhead box protein O3 (FOXO3) Interacting Protein Interacting Protein Info
UniProt ID
FOXO3_HUMAN 
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-Western [114]
Ubiquitin related proteins [+] 4 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-40S ribosomal protein S27a (RPS27A) Interacting Protein Interacting Protein Info
UniProt ID
RS27A_HUMAN 
Synonyms CEP80; HEL112; S27A; UBA80; UBC; UBCEP1; UBCEP80
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [115]
2 Biochemical Activity [115]
3 Yeast two hybrid [84]
Interacting Protein Name Ubiquitin conjugation factor E4 B (UBE4B) Interacting Protein Interacting Protein Info
UniProt ID
UBE4B_HUMAN 
Synonyms E4; HDNB1; UBOX3; UFD2; UFD2A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [116]
2 Co-fractionation [117]
3 Reconstituted Complex [117]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [118]
2 Reconstituted Complex [119]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [120]
2 Reconstituted Complex [121]
Other proteins [+] 15 Other proteins +
Interacting Target Name p53-binding protein Mdm4 (MDM4) Clinical trial Target Interacting Protein Info
UniProt ID
MDM4_HUMAN 
Synonyms Protein Mdmx; p53-binding protein Mdm4; Mdm2-like p53-binding protein; Double minute 4 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [122]
3 Co-crystal Structure [123]
4 Protein-peptide [124]
5 Reconstituted Complex [125]
6 Yeast two hybrid [84]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [126]
2 Biochemical Activity [127]
3 Co-localization [128]
4 Yeast two hybrid [127]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [129]
3 Fluorescence Resonance Energy Transfer [130]
4 Reconstituted Complex [129]
Interacting Protein Name Protein numb homolog (NUMB) Interacting Protein Interacting Protein Info
UniProt ID
NUMB_HUMAN 
Synonyms C14orf41; S171; c14_5527
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [131]
3 Reconstituted Complex [131]
4 Yeast two hybrid [132]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [133]
3 Reconstituted Complex [37]
Interacting Protein Name Mdm2-binding protein (MTBP) Interacting Protein Interacting Protein Info
UniProt ID
MTBP_HUMAN 
Synonyms MDM2BP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [134]
2 Reconstituted Complex [134]
3 Yeast two hybrid [134]
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [135]
2 Reconstituted Complex [136]
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [137]
2 Yeast two hybrid [127]
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [138]
2 Reconstituted Complex [138]
Interacting Target Name Gankyrin (PSMD10) Literature-reported Target Interacting Protein Info
UniProt ID
PSD10_HUMAN 
Synonyms p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [119]
2 Reconstituted Complex [139]
Interacting Protein Name Nibrin (NBN) Interacting Protein Interacting Protein Info
UniProt ID
NBN_HUMAN 
Synonyms AT.V1; AT.V2; ATV; NBS; NBS1; P95
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [140]
2 Affinity Capture-Western [140]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Reconstituted Complex [142]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [143]
2 Reconstituted Complex [144]
Interacting Protein Name Polycomb protein SUZ12 (SUZ12) Interacting Protein Interacting Protein Info
UniProt ID
SUZ12_HUMAN 
Synonyms CHET9; JJAZ1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [145]
Interacting Protein Name Nucleolar transcription factor 1 (UBTF) Interacting Protein Interacting Protein Info
UniProt ID
UBF1_HUMAN 
Synonyms NOR.90; UBF; UBF.1; UBF1; UBF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [20]
2 Protein-peptide [38]
References  Top
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REF 108 MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010 Aug 27;285(35):26908-15.
REF 109 Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. Antioxid Redox Signal. 2011 Feb 15;14(4):563-78.
REF 110 A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity. PLoS One. 2015 Dec 11;10(12):e0144753.
REF 111 Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2. Biochem J. 2009 Mar 15;418(3):575-85.
REF 112 MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci. 2010 Jul 15;123(Pt 14):2423-33.
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REF 114 MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem. 2009 May 22;284(21):13987-4000.
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REF 120 MDMX contains an autoinhibitory sequence element. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17814-9.
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REF 122 Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell. 2009 Aug 14;35(3):316-26.
REF 123 Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 2008 May;15(5):841-8.
REF 124 Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy. Cancer Res. 2015 Nov 1;75(21):4560-72.
REF 125 HDMX folds the nascent p53 mRNA following activation by the ATM kinase. Mol Cell. 2014 May 8;54(3):500-11.
REF 126 Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21;278(8):6363-70.
REF 127 Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov 9;294(5545):1307-13.
REF 128 Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of -arrestin2. Mol Biol Cell. 2011 May;22(9):1608-16.
REF 129 MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem. 2004 Apr 16;279(16):16000-6.
REF 130 MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem. 2010 Jun 11;285(24):18407-14.
REF 131 Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun. 2003 Mar 21;302(4):869-72.
REF 132 MDM2 interacts with and downregulates a sarcomeric protein, TCAP. Biochem Biophys Res Commun. 2006 Jun 23;345(1):355-61.
REF 133 Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene. 2006 Nov 23;25(55):7274-88.
REF 134 A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem. 2000 Oct 13;275(41):31883-90.
REF 135 An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis. J Proteome Res. 2012 Nov 2;11(11):5464-78.
REF 136 Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell. 2004 May;5(5):465-75.
REF 137 Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-53.
REF 138 MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol. 2006 Oct;26(19):7269-82.
REF 139 The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity. Biochem Biophys Res Commun. 2007 Nov 23;363(3):879-84.
REF 140 Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. J Biol Chem. 2005 May 13;280(19):18771-81.
REF 141 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene. 2013 Jun 27;32(26):3156-64.
REF 142 Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J Cell Sci. 2003 Oct 1;116(Pt 19):3917-25.
REF 143 p14ARF interacts with DAXX: effects on HDM2 and p53. Cell Cycle. 2008 Jun 15;7(12):1836-50.
REF 144 Negative regulation of p53 functions by Daxx and the involvement of MDM2. J Biol Chem. 2004 Nov 26;279(48):50566-79.
REF 145 MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell. 2016 Jan 7;61(1):68-83.

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