Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | General transcription factor II-I (GTF2I) | ||||
UniProt ID | GTF2I_HUMAN | ||||
Gene Name | GTF2I | ||||
Gene ID | 2969 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Tyrosine-protein kinase BTK (ATK) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Histone deacetylase 2 (HDAC2) | Target Info | PPI Info | [2] | |
Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [3] | ||
Histone deacetylase 3 (HDAC3) | Target Info | PPI Info | [4] | ||
Interacting Literature-reported Target(s) | Proto-oncogene c-Myc (MYC) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I. J Biol Chem. 2004 Feb 20;279(8):7147-58. | ||||
REF 2 | A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem. 2003 Feb 28;278(9):7234-9. | ||||
REF 3 | A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity. PLoS One. 2015 Dec 11;10(12):e0144753. | ||||
REF 4 | Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. J Biol Chem. 2003 Jan 17;278(3):1841-7. | ||||
REF 5 | Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature. 1993 Sep 23;365(6444):359-61. |
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