Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T36121 Target Info
Target Name Proto-oncogene c-Myc (MYC)
Synonyms Transcription factor p64; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; BHLHE39
Target Type Literature-reported Target
Gene Name MYC
UniProt ID
MYC_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 7 Acid anhydride hydrolases +
Interacting Protein Name E1A-binding protein p400 (EP400) Interacting Protein Interacting Protein Info
UniProt ID
EP400_HUMAN 
Synonyms CAGH32; P400; TNRC12
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-localization [3]
4 Reconstituted Complex [2]
Interacting Protein Name RuvB-like 1 (RUVBL1) Interacting Protein Interacting Protein Info
UniProt ID
RUVB1_HUMAN 
Synonyms ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
3 Co-purification [5]
4 Reconstituted Complex [2]
Interacting Protein Name RuvB-like 2 (RUVBL2) Interacting Protein Interacting Protein Info
UniProt ID
RUVB2_HUMAN 
Synonyms ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [6]
3 Co-purification [5]
4 Reconstituted Complex [7]
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [9]
Interacting Target Name DNA replication licensing factor MCM7 (MCM7) Literature-reported Target Interacting Protein Info
UniProt ID
MCM7_HUMAN 
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [4]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [10]
Interacting Protein Name Structural maintenance of chromosomes protein 4 (SMC4) Interacting Protein Interacting Protein Info
UniProt ID
SMC4_HUMAN 
Synonyms CAP.C; CAPC; SMC.4; SMC4L1; hCAP.C
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Actins [+] 1 Actins +
Interacting Protein Name Actin-like protein 6A (ACTL6A) Interacting Protein Interacting Protein Info
UniProt ID
ACL6A_HUMAN 
Synonyms ACTL6; ARPN.BETA; Arp4; BAF53A; INO80K
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [5]
3 Co-purification [5]
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [13]
3 Co-localization [14]
4 Reconstituted Complex [14]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
3 Yeast two hybrid [15]
Interacting Protein Name Histone acetyltransferase KAT2A (KAT2A) Interacting Protein Interacting Protein Info
UniProt ID
KAT2A_HUMAN 
Synonyms GCN5; GCN5L2; PCAF.b; hGCN5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Fluorescence Resonance Energy Transfer [18]
3 Reconstituted Complex [19]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [20]
Interacting Protein Name Histone acetyltransferase KAT5 (KAT5) Interacting Protein Interacting Protein Info
UniProt ID
KAT5_HUMAN 
Synonyms ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5; cPLA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [24]
3 Reconstituted Complex [22]
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Fluorescence Resonance Energy Transfer [18]
Interacting Protein Name Cyclin-T1 (CCNT1) Interacting Protein Interacting Protein Info
UniProt ID
CCNT1_HUMAN 
Synonyms CCNT; CYCT1; HIVE1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [27]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name DNA mismatch repair protein MSH2 (MSH2) Literature-reported Target Interacting Protein Info
UniProt ID
MSH2_HUMAN 
Synonyms MutS protein homolog 2; Mismatch repair gene Msh2; hMSH2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [28]
Interacting Target Name Protein-tyrosine phosphatase pez (PTPN14) Literature-reported Target Interacting Protein Info
UniProt ID
PTN14_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 14; PTPD2; PEZ
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Glycosylases [+] 1 Glycosylases +
Interacting Protein Name Neutral alpha-glucosidase AB (GANAB) Interacting Protein Interacting Protein Info
UniProt ID
GANAB_HUMAN 
Synonyms G2AN; GLUII
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Protein Name Prelamin-A/C (LMNA) Interacting Protein Interacting Protein Info
UniProt ID
LMNA_HUMAN 
Synonyms CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; PRO1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Kinases [+] 5 Kinases +
Interacting Protein Name Transformation/transcription domain-associated protein (TRRAP) Interacting Protein Interacting Protein Info
UniProt ID
TRRAP_HUMAN 
Synonyms PAF350/400; PAF400; STAF40; TR.AP; Tra1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [29]
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [30]
2 Yeast two hybrid [10]
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [27]
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Biochemical Activity [31]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [32]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Nuclear pore complex protein Nup93 (NUP93) Interacting Protein Interacting Protein Info
UniProt ID
NUP93_HUMAN 
Synonyms NIC96
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [8]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 3A (DNMT3A) Patented-recorded Target Interacting Protein Info
UniProt ID
DNM3A_HUMAN 
Synonyms M.HsaIIIA; Dnmt3a; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA (cytosine-5)-methyltransferase 3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [33]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name NADH-ubiquinone oxidoreductase core subunit S2 (NDUFS2) Interacting Protein Interacting Protein Info
UniProt ID
NDUS2_HUMAN 
Synonyms CI.49
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 22 (USP22) Interacting Protein Interacting Protein Info
UniProt ID
UBP22_HUMAN 
Synonyms USP3L
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Co-localization [35]
3 Reconstituted Complex [34]
Proteasome components [+] 1 Proteasome components +
Interacting Protein Name Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2) Interacting Protein Interacting Protein Info
UniProt ID
PSMD2_HUMAN 
Synonyms P97; RPN1; S2; TRAP2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Transcription regulators [+] 11 Transcription regulators +
Interacting Protein Name Protein max (MAX) Interacting Protein Interacting Protein Info
UniProt ID
MAX_HUMAN 
Synonyms bHLHd4
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Co-crystal Structure [36]
4 Co-fractionation [37]
5 Reconstituted Complex [38]
6 Yeast two hybrid [39]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Biochemical Activity [41]
3 Reconstituted Complex [41]
4 Yeast two hybrid [41]
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Fluorescence Resonance Energy Transfer [18]
3 Reconstituted Complex [42]
4 Yeast two hybrid [42]
Interacting Protein Name N-myc-interactor (NMI) Interacting Protein Interacting Protein Info
UniProt ID
NMI_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Reconstituted Complex [43]
3 Yeast two hybrid [44]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Fluorescence Resonance Energy Transfer [18]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Reconstituted Complex [47]
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [48]
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Reconstituted Complex [49]
Interacting Protein Name SWI/SNF complex subunit SMARCC1 (SMARCC1) Interacting Protein Interacting Protein Info
UniProt ID
SMRC1_HUMAN 
Synonyms BAF155; CRACC1; Rsc8; SRG3; SWI3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [9]
Interacting Protein Name Zinc finger and BTB domain-containing protein 17 (ZBTB17) Interacting Protein Interacting Protein Info
UniProt ID
ZBT17_HUMAN 
Synonyms MIZ.1; ZNF151; ZNF60; pHZ.67
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [51]
Interacting Protein Name A-kinase anchor protein 8 (AKAP8) Interacting Protein Interacting Protein Info
UniProt ID
AKAP8_HUMAN 
Synonyms AKAP 95; AKAP.8; AKAP.95; AKAP95
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Translocases [+] 1 Translocases +
Interacting Protein Name ATP synthase membrane subunit f (ATP5MF) Interacting Protein Interacting Protein Info
UniProt ID
ATPK_HUMAN 
Synonyms ATP5JL
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Other proteins [+] 14 Other proteins +
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [52]
3 Reconstituted Complex [52]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Protein-Fragment Complementation Assay [53]
3 Reconstituted Complex [53]
Interacting Protein Name Myc box-dependent-interacting protein 1 (BIN1) Interacting Protein Interacting Protein Info
UniProt ID
BIN1_HUMAN 
Synonyms AMPH2; AMPHL; SH3P9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Reconstituted Complex [55]
3 Yeast two hybrid [54]
Interacting Protein Name Cell cycle and apoptosis regulator protein 2 (CCAR2) Interacting Protein Interacting Protein Info
UniProt ID
CCAR2_HUMAN 
Synonyms DBC.1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [4]
Interacting Protein Name Prefoldin subunit 5 (PFDN5) Interacting Protein Interacting Protein Info
UniProt ID
PFD5_HUMAN 
Synonyms MM.1; MM1; PFD5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Reconstituted Complex [57]
3 Yeast two hybrid [58]
Interacting Protein Name eIF-2-alpha kinase activator GCN1 (GCN1) Interacting Protein Interacting Protein Info
UniProt ID
GCN1_HUMAN 
Synonyms GCN1; GCN1L; PRIC295
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Yeast two hybrid [59]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Reconstituted Complex [61]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [10]
Interacting Protein Name Integrase interactor 1 protein (SMARCB1) Interacting Protein Interacting Protein Info
UniProt ID
SNF5_HUMAN 
Synonyms BAF47; INI1; MRD15; PPP1R144; RDT; RTPS1; SNF5; SNF5L1; SWNTS1; Sfh1p; Snr1; hSNFS
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Yeast two hybrid [39]
Interacting Protein Name Transcription initiation protein SPT3 homolog (SUPT3H) Interacting Protein Interacting Protein Info
UniProt ID
SUPT3_HUMAN 
Synonyms SPT3; SPT3L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [19]
Interacting Protein Name Elongation factor 1-gamma (EEF1G) Interacting Protein Interacting Protein Info
UniProt ID
EF1G_HUMAN 
Synonyms EF1G; GIG35
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Interacting Protein Name Non-POU domain-containing octamer-binding protein (NONO) Interacting Protein Interacting Protein Info
UniProt ID
NONO_HUMAN 
Synonyms NMT55; NRB54; P54; P54NRB; PPP1R114
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Interacting Protein Name Pre-mRNA-processing factor 6 (PRPF6) Interacting Protein Interacting Protein Info
UniProt ID
PRP6_HUMAN 
Synonyms ANT.1; ANT1; C20orf14; Prp6; RP60; SNRNP102; TOM; U5.102K; hPrp6
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Interacting Protein Name Tubulin alpha-4A chain (TUBA4A) Interacting Protein Interacting Protein Info
UniProt ID
TBA4A_HUMAN 
Synonyms H2.ALPHA; TUBA1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
References  Top
REF 1 A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010 Oct 15;143(2):313-24.
REF 2 The p400 complex is an essential E1A transformation target. Cell. 2001 Aug 10;106(3):297-307.
REF 3 Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6103-8.
REF 4 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007 Jan 15;6(2):205-17.
REF 5 BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002 Mar;22(5):1307-16.
REF 6 Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer. Mol Cancer. 2010 May 30;9:132.
REF 7 c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003 May 30;278(22):20405-12.
REF 8 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 9 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol. 2003 Nov;23(21):7475-87.
REF 10 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 11 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 12 Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 2005 Jan 12;24(1):85-96.
REF 13 Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun. 2005 Oct 14;336(1):274-80.
REF 14 Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol. 2005 Dec;25(23):10220-34.
REF 15 BRCA1 inhibition of telomerase activity in cultured cells. Mol Cell Biol. 2003 Dec;23(23):8668-90.
REF 16 BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene. 1998 Oct 15;17(15):1939-48.
REF 17 The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol. 2000 Jan;20(2):556-62.
REF 18 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 19 STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol Cell Biol. 2008 Jan;28(1):108-21.
REF 20 The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity. Oncogene. 2013 Mar 7;32(10):1284-95.
REF 21 MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep. 2003 Jun;4(6):575-80.
REF 22 Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18682-7.
REF 23 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 24 Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis. Cancer Sci. 2008 Feb;99(2):309-15.
REF 25 Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):978-83.
REF 26 c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene. 2003 Aug 28;22(36):5707-11.
REF 27 c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem. 2001 Dec 21;276(51):48562-71.
REF 28 Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX. Oncogene. 2003 Feb 13;22(6):819-25.
REF 29 The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. 1998 Aug 7;94(3):363-74.
REF 30 A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell. 2011 Nov 15;20(5):620-34.
REF 31 A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity. Sci Rep. 2017 Jun 15;7(1):3598.
REF 32 c-Raf kinase binds to N-terminal domain of c-Myc. FEBS Lett. 1997 Sep 8;414(2):465-70.
REF 33 Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005 Jan 26;24(2):336-46.
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