Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Cyclin-dependent kinase 9 (CDK9) | Clinical trial | Target Info | ||
UniProt ID | CDK9_HUMAN | ||||
Gene Name | CDK9 | ||||
Gene ID | 1025 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [1] | |
Sodium pump subunit alpha-1 (ATP1A1) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | Cyclin-dependent kinase 9 (CDK9) | Target Info | PPI Info | [3] | |
Bromodomain-containing protein 4 (BRD4) | Target Info | PPI Info | [4] | ||
Interacting Literature-reported Target(s) | Proto-oncogene c-Myc (MYC) | Target Info | PPI Info | [5] | |
FK506-binding protein 5 (FKBP5) | Target Info | PPI Info | [6] | ||
Hsp90 co-chaperone Cdc37 (CDC37) | Target Info | PPI Info | [1] | ||
DNA mismatch repair protein MSH2 (MSH2) | Target Info | PPI Info | [2] | ||
Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) | Target Info | PPI Info | [7] | ||
Structural maintenance of chromosomes protein 2 (SMC2) | Target Info | PPI Info | [8] |
References | Top | ||||
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REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
REF 3 | TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9;142(1):133-43. | ||||
REF 4 | The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell. 2005 Aug 19;19(4):523-34. | ||||
REF 5 | c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene. 2003 Aug 28;22(36):5707-11. | ||||
REF 6 | USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. EMBO J. 2017 May 15;36(10):1434-1446. | ||||
REF 7 | The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 2018 May 30;7. pii: e31879. | ||||
REF 8 | A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9. |
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