Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94366 Target Info
Target Name Hsp90 co-chaperone Cdc37 (CDC37)
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Target Type Literature-reported Target
Gene Name CDC37
UniProt ID
CDC37_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine-protein phosphatase 5 (PPP5C) Patented-recorded Target Interacting Protein Info
UniProt ID
PPP5_HUMAN 
Synonyms Protein phosphatase T; PPT protein; PP-T; PPP5; PP5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [2]
4 Biochemical Activity [3]
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Co-crystal Structure [8]
4 Reconstituted Complex [9]
Kinases [+] 10 Kinases +
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [11]
3 Co-fractionation [12]
4 Yeast two hybrid [13]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Co-purification [15]
3 Reconstituted Complex [15]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [17]
Interacting Target Name Tropomyosin-related kinase A (TrkA) Successful Target Interacting Protein Info
UniProt ID
NTRK1_HUMAN 
Synonyms Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-Western [19]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [9]
Interacting Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target Interacting Protein Info
UniProt ID
LRRK2_HUMAN 
Synonyms PARK8; LRRK2 S935 phosphorylation; LRRK2 G2019S mutation; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [22]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Reconstituted Complex [15]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [23]
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [10]
Interacting Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target Interacting Protein Info
UniProt ID
ACK1_HUMAN 
Synonyms Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [24]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics. 2011 Apr;11(8):1508-16.
REF 3 Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. Cell Rep. 2017 Nov 14;21(7):1883-1895.
REF 4 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 5 Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines. Oncogene. 2007 Nov 8;26(51):7185-93.
REF 6 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics. 2010 Feb;9(2):255-70.
REF 7 Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell. 2010 Feb 12;37(3):333-43.
REF 8 The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell. 2004 Jan 9;116(1):87-98.
REF 9 Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun;1823(6):1092-101.
REF 10 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 11 Physical interaction of mammalian CDC37 with CDK4. J Biol Chem. 1996 Sep 6;271(36):22030-4.
REF 12 Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 1996 Jun 15;10(12):1491-502.
REF 13 Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997 Apr 24;14(16):1999-2004.
REF 14 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 15 TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell. 2002 Feb;9(2):401-10.
REF 16 Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Proteomics. 2013 Nov;13(21):3131-44.
REF 17 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 18 Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Sci Signal. 2015 Apr 28;8(374):ra40.
REF 19 Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. Mol Cancer Ther. 2010 Aug;9(8):2232-42.
REF 20 Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem. 2002 Oct 18;277(42):39858-66.
REF 21 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010 Sep 15;430(3):393-404.
REF 22 The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci. 2008 Mar 26;28(13):3384-91.
REF 23 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34.
REF 24 HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3. Cell Signal. 2017 Nov;39:9-17.

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