Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | M-phase inducer phosphatase 3 (MPIP3) | Literature-reported | Target Info | ||
UniProt ID | MPIP3_HUMAN | ||||
Gene Name | CDC25C | ||||
Gene ID | 995 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Cyclin-dependent kinase 1 (CDK1) | Target Info | PPI Info | [2] | |
Microtubule affinity regulating kinase 3 (MARK3) | Target Info | PPI Info | [3] | ||
Polo-like kinase 1 (PLK1) | Target Info | PPI Info | [4] | ||
Rotamase Pin1 (PIN1) | Target Info | PPI Info | [5] | ||
Proliferating cell nuclear antigen (PCNA) | Target Info | PPI Info | [6] | ||
Interacting Literature-reported Target(s) | Hsp90 co-chaperone Cdc37 (CDC37) | Target Info | PPI Info | [7] | |
AS1 14-3-3 protein eta (YWHAH) | Target Info | PPI Info | [2] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501. | ||||
REF 3 | Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. J Cell Sci. 2006 Oct 1;119(Pt 19):4059-70. | ||||
REF 4 | BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene. 2009 Aug 6;28(31):2806-20. | ||||
REF 5 | The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 1;12(5):706-20. | ||||
REF 6 | Cdc25C interacts with PCNA at G2/M transition. Oncogene. 2002 Mar 7;21(11):1717-26. | ||||
REF 7 | Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44. |
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