Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16308 Target Info
Target Name Rotamase Pin1 (PIN1)
Synonyms Prolyl isomerase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1; PPIase Pin1
Target Type Clinical trial Target
Gene Name PIN1
Biochemical Class Cis-trans-isomerase
UniProt ID
PIN1_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Protein-peptide [3]
Kinases [+] 2 Kinases +
Interacting Target Name Pyruvate kinase M2 (PKM) Clinical trial Target Interacting Protein Info
UniProt ID
KPYM_HUMAN 
Synonyms Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase PKM; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase 2/3; PKM2; PK3; PK2; p58; Opa-interacting protein 3; OIP-3; OIP3; Cytosolic thyroid hormone-binding protein; CTHBP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [4]
3 Protein-peptide [4]
4 Reconstituted Complex [5]
5 Yeast two hybrid [6]
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [7]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [11]
3 Reconstituted Complex [12]
4 Reconstituted Complex [10]
5 Yeast two hybrid [6]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [13]
4 Yeast two hybrid [15]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [13]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [20]
4 Affinity Capture-Western [21]
5 Reconstituted Complex [19]
Interacting Protein Name Protein PRRC1 (PRRC1) Interacting Protein Interacting Protein Info
UniProt ID
PRRC1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [5]
2 Yeast two hybrid [22]
Interacting Protein Name Transcription elongation factor SPT5 (SUPT5H) Interacting Protein Interacting Protein Info
UniProt ID
SPT5H_HUMAN 
Synonyms SPT5; SPT5H; Tat.CT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Yeast two hybrid [15]
References  Top
REF 1 The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 1;12(5):706-20.
REF 2 Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science. 1999 Feb 26;283(5406):1325-8.
REF 3 The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001 Nov;21(22):7617-28.
REF 4 ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec;14(12):1295-304.
REF 5 WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol. 2005 Aug;25(16):7092-106.
REF 6 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 7 Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J Biol Chem. 2005 Nov 4;280(44):36575-83.
REF 8 Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. J Biol Chem. 2006 Feb 17;281(7):4117-25.
REF 9 The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999 Jun 24;399(6738):784-8.
REF 10 The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 2002 Oct 24;419(6909):853-7.
REF 11 Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 2002 Dec 13;277(50):47976-9.
REF 12 The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol. 2007 Oct;14(10):912-20.
REF 13 Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem. 2009 Mar 6;284(10):6109-15.
REF 14 Pin1 promotes transforming growth factor-beta-induced migration and invasion. J Biol Chem. 2010 Jan 15;285(3):1754-64.
REF 15 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 16 Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 2001 Jul 2;20(13):3459-72.
REF 17 Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018 Jan 2;26(1):28-39.e2.
REF 18 Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. Mol Cell Biol. 2008 Feb;28(3):997-1006.
REF 19 Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1. J Biol Chem. 2010 Mar 26;285(13):9485-92.
REF 20 Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover. J Biol Chem. 2011 Dec 30;286(52):44403-11.
REF 21 Implication of PMLIV in both intrinsic and innate immunity. PLoS Pathog. 2014 Feb 27;10(2):e1003975.
REF 22 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 23 The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9. J Mol Biol. 2001 Sep 28;312(4):675-85.

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